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Chemical Compound Review

NSC-65989     2-amino-7,9-dihydropurin-8-one

Synonyms: NSC65989, AKOS015966691, AC1NS9O3, 6957-76-2, NCIOpen2_000022, ...
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Disease relevance of NSC65989


Psychiatry related information on NSC65989

  • The urinary concentration of 8-hydroxydeoxyguanine (8-OHdG), which is a biomarker of oxidative DNA damage, was measured in 248 healthy Japanese, and its correlations with life style, urinary metal elements, serum antioxidants, and other plasma or serum factors were investigated [2].

High impact information on NSC65989


Biological context of NSC65989


Anatomical context of NSC65989


Gene context of NSC65989


Analytical, diagnostic and therapeutic context of NSC65989


  1. Evaluation of DNA damage in patients with arsenic poisoning: urinary 8-hydroxydeoxyguanine. Yamauchi, H., Aminaka, Y., Yoshida, K., Sun, G., Pi, J., Waalkes, M.P. Toxicol. Appl. Pharmacol. (2004) [Pubmed]
  2. Evaluation of Urinary 8-Hydroxydeoxyguanine inHealthy Japanese People. Kimura, S., Yamauchi, H., Hibino, Y., Iwamoto, M., Sera, K., Ogino, K. Basic & clinical pharmacology & toxicology. (2006) [Pubmed]
  3. Functional implications of antiestrogen induction of quinone reductase: inhibition of estrogen-induced deoxyribonucleic acid damage. Bianco, N.R., Perry, G., Smith, M.A., Templeton, D.J., Montano, M.M. Mol. Endocrinol. (2003) [Pubmed]
  4. Transient modifications of respiratory capacity in thymic cells during murine radioleukemogenesis. Verlaet, M., Duyckaerts, C., Rahmouni, S., Denis, G., Humblet, C., Greimers, R., Sluse, F.E., Boniver, J., Defresne, M.P. Free Radic. Biol. Med. (2002) [Pubmed]
  5. 8-oxodGTP incorporation by DNA polymerase beta is modified by active-site residue Asn279. Miller, H., Prasad, R., Wilson, S.H., Johnson, F., Grollman, A.P. Biochemistry (2000) [Pubmed]
  6. DNA damage and repair system in spinal cord ischemia. Lin, R., Roseborough, G., Dong, Y., Williams, G.M., Wei, C. J. Vasc. Surg. (2003) [Pubmed]
  7. Changes of 8-OH-dG levels in DNA and its base excision repair activity in rat lungs after inhalation exposure to hexavalent chromium. Maeng, S.H., Chung, H.W., Yu, I.J., Kim, H.Y., Lim, C.H., Kim, K.J., Kim, S.J., Ootsuyama, Y., Kasai, H. Mutat. Res. (2003) [Pubmed]
  8. Prevention by synthetic phenolic antioxidants of 2-amino-3, 8-dimethylimidazo[4,5-f]quinoxaline (MeIQx)- or activated MeIQx-induced mutagenesis and MeIQx-induced rat hepatocarcinogenesis, and role of antioxidant activity in the prevention of carcinogenesis. Hirose, M., Ito, T., Takahashi, S., Ozaki, M., Ogiso, T., Nihro, Y., Miki, T., Shirai, T. Eur. J. Cancer Prev. (1998) [Pubmed]
  9. Antioxidant activity of soya hypocotyl tea in humans. Watanabe, S., Haba, R., Terashima, K., Arai, Y., Miura, T., Chiba, H., Takamatsu, K. Biofactors (2000) [Pubmed]
  10. Human 8-oxoguanine DNA glycosylase 1 mRNA expression as an oxidative stress exposure biomarker of cooking oil fumes. Cherng, S.H., Huang, K.H., Yang, S.C., Wu, T.C., Yang, J.L., Lee, H. J. Toxicol. Environ. Health Part A (2002) [Pubmed]
  11. hOGG1 Ser326Cys polymorphism, interaction with environmental exposures, and gastric cancer risk in Japanese populations. Tsukino, H., Hanaoka, T., Otani, T., Iwasaki, M., Kobayashi, M., Hara, M., Natsukawa, S., Shaura, K., Koizumi, Y., Kasuga, Y., Tsugane, S. Cancer Sci. (2004) [Pubmed]
  12. Inflammatory and genotoxic responses during 30-day welding-fume exposure period. Yu, I.J., Song, K.S., Maeng, S.H., Kim, S.J., Sung, J.H., Han, J.H., Chung, Y.H., Cho, M.H., Chung, K.H., Han, K.T., Hyun, J.S., Kim, K.J. Toxicol. Lett. (2004) [Pubmed]
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