Disease relevance of Arsenic Poisoning

• Endemic arsenic poisoning manifested by palmoplantar keratoderma and hyperpigmentation was surveyed in a village in a tin and wolfram mining area in southern Thailand where two cases of Bowen's carcinoma had occurred [1].

Psychiatry related information on Arsenic Poisoning

• Imbalance of this cycle in humans, e.g. through folate shortage via dietary insufficiency, alcohol abuse, arsenic poisoning or hereditary factors, leads to depletion of SAM and human disease [2].

High impact information on Arsenic Poisoning

• The pharmacology of 2,3-dimercaptosuccinic acid and its potential use in arsenic poisoning [3].
• The use of D-penicillamine in arsenic poisoning has not been generally appreciated [4].
• No characteristic findings of arsenic poisoning, that is, gastrointestinal disturbance, disorder of the cardiovascular system, hematopoietic disorders, or liver disturbance were observed in the retired workers [5].
• Therefore, the present results suggest the necessity of reevaluating the therapeutic effect of these dithiol compounds for arsenic poisoning [6].
• Because accumulation of methylated arsenicals may occur in patients with chronic arsenic poisoning and arsenic-treated APL patients, this study may provide important information regarding chronic arsenic poisoning and the latent risk of developing multidrug resistance in APL therapy using inorganic arsenite [7].

Chemical compound and disease context of Arsenic Poisoning

• A remarkable increase in 8-OHdG in the urine was observed in 60% of 52 patients with acute arsenic poisoning from the accidental oral intake of the arsenic trioxide [8].
• This study demonstrates that glutathione depletion elicits the nephrotoxic manifestations of arsenic poisoning [9].
• Evaluation of the efficacy of dimercapto chelating agents for the treatment of systemic organic arsenic poisoning in rabbits [10].
• 1 The standard drug for the treatment of arsenic poisoning is BAL (dimercaprol) [10].
• Carbohydrate depletion (glucose and glycogen) was reported to be a major problem in acute arsenic poisoning [11].

Biological context of Arsenic Poisoning

• Chelating agents used in clinical treatment of acute and chronic inorganic arsenic poisoning lower the methylation capacity of cytosol by rendering the trivalent arsenic unavailable for the methyltransferase enzymes [12].
• Using TESS, we have identified several events of potential public health significance, including an arsenic poisoning at a local church gathering in Maine, the TOPOFF 2 national preparedness exercise, and contaminated food and water during the northeastern US blackout [13].

Gene context of Arsenic Poisoning

• We propose to consider early hemodialysis as an elimination measure in massive arsenic poisoning and to choose BAL as a chelator when dialysis is required [14].
• Our results also suggest that increasing the intracellular antioxidant level may have preventive or therapeutic effects in arsenic poisoning [15].
• The authors developed the Japanese-language version of the Impact of Event Scale-Revised (IES-R-J) and investigated its reliability and validity in four different groups: workers with lifetime mixed traumatic events, survivors of an arsenic poisoning case, survivors of the Hanshin-Awaji earthquake, and survivors of the Tokyo Metro sarin attack [16].
• These results raise the question as to the appropriateness of BAL as the treatment for systemic arsenic poisoning [17].
• Meso 2, 3, -dimercaptosuccinic acid (DMSA) has been tried successfully in animals as well as in a few cases of human lead and arsenic poisoning [18].

Analytical, diagnostic and therapeutic context of Arsenic Poisoning

• Oral chelation therapy with D-penicillamine has rarely been reported as an effective agent in the treatment of arsenic poisoning [19].

References