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Chemical Compound Review

CHEBI:63886     (3Z)-5-[[4-chloro-6-[[4-[[4- chloro-6...

Synonyms: AC1NUZ8P, Reactive red 120 dye
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High impact information on Reactive Red 120

  • The cytochrome P-450 enzyme was solubilized with the detergents Renex 690, reduced Triton X-100, and 3-[(3-cholamidopropyl)dimethylammonio]-1-propanesulfonate and isolated by ion-exchange (DEAE-Sepharose) and dye (Cibacron blue and reactive red 120) column chromatography [1].
  • Proteins from sarcoplasmic reticulum vesicles solubilized by a nonionic detergent were fractionated by use of a reactive red-120 agarose column [2].
  • The procedure consisted of octylglucoside solubilization of Pgp from plasma membranes and chromatography on Reactive Red 120 agarose [3].
  • 1. Four calpain II heterodimers (80 kDa/30 kDa, 80 kDa/29 kDa, 80 kDa/26 kDa and 80 kDa/18 kDa) were isolated from fresh porcine kidney by (NH4)2SO4 precipitation, chromatography on DEAE-Sepharose CL-6B and subsequently on Reactive Red 120/agarose followed by f.p.l.c. on a Q-Sepharose Hi-Load 16/10 column [4].
  • The presence of lipid during the octylglucoside solubilization and Reactive Red 120 chromatography steps was found to be mandatory for retention of ATPase activity [5].

Biological context of Reactive Red 120

  • In the first step, the yeast cell extract is fractionated efficiently by biomimetic chromatography using the dye HE-3B (reactive Red 120) as pseudoaffinity ligand coupled to Sepharose CL-4B [6].
  • For the Reactive-Red-120-inhibited enzyme, the level of steady-state enzyme phosphorylation by ATP was not significantly different from that exhibited by the control Ca2+-ATPase [7].
  • The decomposition rate of Reactive Red 120 and Acid Red 299 dyes via ozonation can be described by the pseudo-first-order kinetics [8].

Anatomical context of Reactive Red 120


Associations of Reactive Red 120 with other chemical compounds


Gene context of Reactive Red 120


Analytical, diagnostic and therapeutic context of Reactive Red 120


  1. Isolation of the heme-thiolate enzyme cytochrome P-450TYR, which catalyzes the committed step in the biosynthesis of the cyanogenic glucoside dhurrin in Sorghum bicolor (L.) Moench. Sibbesen, O., Koch, B., Halkier, B.A., Møller, B.L. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  2. Purification of the CaATPase of sarcoplasmic reticulum by affinity chromatography. Coll, R.J., Murphy, A.J. J. Biol. Chem. (1984) [Pubmed]
  3. Characterization of the ATPase activity of purified Chinese hamster P-glycoprotein. Urbatsch, I.L., al-Shawi, M.K., Senior, A.E. Biochemistry (1994) [Pubmed]
  4. Catalytic-site characteristics of the porcine calpain II 80 kDa/18 kDa heterodimer revealed by selective reaction of its essential thiol group with two-hydronic-state time-dependent inhibitors: evidence for a catalytic site Cys/His interactive system and an ionizing modulatory group. Mellor, G.W., Sreedharan, S.K., Kowlessur, D., Thomas, E.W., Brocklehurst, K. Biochem. J. (1993) [Pubmed]
  5. Effects of lipids on ATPase activity of purified Chinese hamster P-glycoprotein. Urbatsch, I.L., Senior, A.E. Arch. Biochem. Biophys. (1995) [Pubmed]
  6. D-Xylose metabolism by Candida intermedia: isolation and characterisation of two forms of aldose reductase with different coenzyme specificities. Mayr, P., Brüggler, K., Kulbe, K.D., Nidetzky, B. J. Chromatogr. B Biomed. Sci. Appl. (2000) [Pubmed]
  7. Inhibition of the sarcoplasmic reticulum Ca2+-ATPase by Reactive Red 120. Coll, R.J., Murphy, A.J. Biochim. Biophys. Acta (1987) [Pubmed]
  8. Ozonation of dyes and textile wastewater in a rotating packed bed. Shang, N.C., Chen, Y.H., Yang, Y.P., Chang, C.H., Yu, Y.H. Journal of environmental science and health. Part A, Toxic/hazardous substances & environmental engineering. (2006) [Pubmed]
  9. Activation of the skeletal muscle Ca2+ release channel by the triazine dyes cibacron blue F3A-G and reactive red 120. Xu, L., Jones, R.V., Meissner, G. Arch. Biochem. Biophys. (1989) [Pubmed]
  10. Isolation of adenosine diphosphoribosyltransferase by precipitation with reactive red 120 combined with affinity chromatography. Buki, K.G., Kirsten, E., Kun, E. Anal. Biochem. (1987) [Pubmed]
  11. Triazine dyes as inhibitors and affinity ligands of glycosyltransferases. Kamińska, J., Dziecioł, J., Kościelak, J. Glycoconj. J. (1999) [Pubmed]
  12. Purification and characterization of calmodulin (lysine 115) N-methyltransferase from Paramecium tetraurelia. Pech, L.L., Nelson, D.L. Biochim. Biophys. Acta (1994) [Pubmed]
  13. Purification and reconstitution of human P-glycoprotein. Ambudkar, S.V., Lelong, I.H., Zhang, J., Cardarelli, C. Meth. Enzymol. (1998) [Pubmed]
  14. Lyophilized Clostridium perfringens 3 alpha- and Clostridium bifermentans 7 alpha-hydroxysteroid dehydrogenases: two new stable enzyme preparations for routine bile acid analysis. Sutherland, J.D., Hutchison, D.M., Williams, C.N. Biochim. Biophys. Acta (1988) [Pubmed]
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