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Gene Review

DHRS9  -  dehydrogenase/reductase (SDR family) member 9

Homo sapiens

Synonyms: 3-alpha hydroxysteroid dehydrogenase, 3-alpha-HSD, 3ALPHA-HSD, 3alpha-HSD, Dehydrogenase/reductase SDR family member 9, ...
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Disease relevance of DHRS9


High impact information on DHRS9


Chemical compound and disease context of DHRS9


Biological context of DHRS9


Anatomical context of DHRS9


Associations of DHRS9 with chemical compounds


Regulatory relationships of DHRS9


Other interactions of DHRS9

  • The colon-specific transcription factor CDX2, however, activated an RDHL promoter construct and induced endogenous RDHL [2].
  • Whereas AKR1C2 acted as a 3alpha-HSD toward 5alpha-DHT, it functioned exclusively as a 3beta-HSD on tibolone [18].
  • 3alpha-hydroxysteroid dehydrogenase (3alpha-HSD) isoforms (AKR1C1-AKR1C4) are aldo-keto reductases that metabolize steroids and other substances in many tissues including the CNS [19].
  • Calculation of KM and kcat values of each isoform for model substrates revealed that they possessed enzymatic activities assigned to native human liver DD1, DD2, DD4, and type 2 3alpha-HSD (DDX) proteins [20].
  • Type 2 3alpha-HSD was cloned from human prostate, is a member of the aldo-keto reductase (AKR) superfamily and was named AKR1C3 [21].

Analytical, diagnostic and therapeutic context of DHRS9


  1. Adenomatous polyposis coli control of retinoic acid biosynthesis is critical for zebrafish intestinal development and differentiation. Nadauld, L.D., Sandoval, I.T., Chidester, S., Yost, H.J., Jones, D.A. J. Biol. Chem. (2004) [Pubmed]
  2. The tumor suppressor adenomatous polyposis coli and caudal related homeodomain protein regulate expression of retinol dehydrogenase L. Jette, C., Peterson, P.W., Sandoval, I.T., Manos, E.J., Hadley, E., Ireland, C.M., Jones, D.A. J. Biol. Chem. (2004) [Pubmed]
  3. Isolation of novel microbial 3 alpha-, 3 beta-, and 17 beta-hydroxysteroid dehydrogenases. Purification, characterization, and analytical applications of a 17 beta-hydroxysteroid dehydrogenase from an Alcaligenes sp. Payne, D.W., Talalay, P. J. Biol. Chem. (1985) [Pubmed]
  4. Expression and characterization of recombinant type 2 3 alpha-hydroxysteroid dehydrogenase (HSD) from human prostate: demonstration of bifunctional 3 alpha/17 beta-HSD activity and cellular distribution. Lin, H.K., Jez, J.M., Schlegel, B.P., Peehl, D.M., Pachter, J.A., Penning, T.M. Mol. Endocrinol. (1997) [Pubmed]
  5. Characterization of brain neurons that express enzymes mediating neurosteroid biosynthesis. Ag??s-Balboa, R.C., Pinna, G., Zhubi, A., Maloku, E., Veldic, M., Costa, E., Guidotti, A. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  6. Androgen receptors, androgen-dependent proliferation, and 5 alpha-reductase activity of small-cell lung cancer cell lines. Maasberg, M., Rotsch, M., Jaques, G., Enderle-Schmidt, U., Weehle, R., Havemann, K. Int. J. Cancer (1989) [Pubmed]
  7. Regulation of 3alpha-hydroxysteroid dehydrogenase/carbonyl reductase in Comamonas testosteroni: function and relationship of two operators. Xiong, G., Markowetz, S., Maser, E. Chem. Biol. Interact. (2003) [Pubmed]
  8. Function of human brain short chain L-3-hydroxyacyl coenzyme A dehydrogenase in androgen metabolism. He, X.Y., Merz, G., Yang, Y.Z., Pullakart, R., Mehta, P., Schulz, H., Yang, S.Y. Biochim. Biophys. Acta (2000) [Pubmed]
  9. Discrete analysis of bile acid in serum and bile with 3alpha-hydroxysteroid dehydrogenase and diaphorase immobilized onto alkylamine glass beads. Rani, K., Garg, P., Pundir, C.S. Indian J. Biochem. Biophys. (2006) [Pubmed]
  10. Mechanistic roles of Ser-114, Tyr-155, and Lys-159 in 3alpha-hydroxysteroid dehydrogenase/carbonyl reductase from Comamonas testosteroni. Hwang, C.C., Chang, Y.H., Hsu, C.N., Hsu, H.H., Li, C.W., Pon, H.I. J. Biol. Chem. (2005) [Pubmed]
  11. Local androgen inactivation in abdominal visceral adipose tissue. Blouin, K., Richard, C., Bélanger, C., Dupont, P., Daris, M., Laberge, P., Luu-The, V., Tchernof, A. J. Clin. Endocrinol. Metab. (2003) [Pubmed]
  12. Activation of human liver 3 alpha-hydroxysteroid dehydrogenase by sulphobromophthalein. Matsuura, K., Tamada, Y., Deyashiki, Y., Miyabe, Y., Nakanishi, M., Ohya, I., Hara, A. Biochem. J. (1996) [Pubmed]
  13. Human 3alpha-hydroxysteroid dehydrogenase isoforms (AKR1C1-AKR1C4) of the aldo-keto reductase superfamily: functional plasticity and tissue distribution reveals roles in the inactivation and formation of male and female sex hormones. Penning, T.M., Burczynski, M.E., Jez, J.M., Hung, C.F., Lin, H.K., Ma, H., Moore, M., Palackal, N., Ratnam, K. Biochem. J. (2000) [Pubmed]
  14. Regio- and stereospecificity of homogeneous 3 alpha-hydroxysteroid-dihydrodiol dehydrogenase for trans-dihydrodiol metabolites of polycyclic aromatic hydrocarbons. Smithgall, T.E., Harvey, R.G., Penning, T.M. J. Biol. Chem. (1986) [Pubmed]
  15. Selective serotonin reuptake inhibitors directly alter activity of neurosteroidogenic enzymes. Griffin, L.D., Mellon, S.H. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  16. Influence of mirtazapine on plasma concentrations of neuroactive steroids in major depression and on 3alpha-hydroxysteroid dehydrogenase activity. Schüle, C., Romeo, E., Uzunov, D.P., Eser, D., di Michele, F., Baghai, T.C., Pasini, A., Schwarz, M., Kempter, H., Rupprecht, R. Mol. Psychiatry (2006) [Pubmed]
  17. Decreased urinary 5 alpha-androstane-3 alpha,17 beta-diol glucuronide excretion in patients with benign prostatic hyperplasia. Wright, F., Poizat, R., Bongini, M., Bozzolan, F., Doukani, A., Mauvais-Jarvis, P. J. Clin. Endocrinol. Metab. (1985) [Pubmed]
  18. Tibolone is metabolized by the 3alpha/3beta-hydroxysteroid dehydrogenase activities of the four human isozymes of the aldo-keto reductase 1C subfamily: inversion of stereospecificity with a delta5(10)-3-ketosteroid. Steckelbroeck, S., Jin, Y., Oyesanmi, B., Kloosterboer, H.J., Penning, T.M. Mol. Pharmacol. (2004) [Pubmed]
  19. Altered expression of 3 alpha-hydroxysteroid dehydrogenases in human glaucomatous optic nerve head astrocytes. Agapova, O.A., Yang, P., Wang, W.H., Lane, D.A., Clark, A.F., Weinstein, B.I., Hernandez, M.R. Neurobiol. Dis. (2003) [Pubmed]
  20. Expression and characterization of four recombinant human dihydrodiol dehydrogenase isoforms: oxidation of trans-7, 8-dihydroxy-7,8-dihydrobenzo[a]pyrene to the activated o-quinone metabolite benzo[a]pyrene-7,8-dione. Burczynski, M.E., Harvey, R.G., Penning, T.M. Biochemistry (1998) [Pubmed]
  21. Increased expression of type 2 3alpha-hydroxysteroid dehydrogenase/type 5 17beta-hydroxysteroid dehydrogenase (AKR1C3) and its relationship with androgen receptor in prostate carcinoma. Fung, K.M., Samara, E.N., Wong, C., Metwalli, A., Krlin, R., Bane, B., Liu, C.Z., Yang, J.T., Pitha, J.V., Culkin, D.J., Kropp, B.P., Penning, T.M., Lin, H.K. Endocr. Relat. Cancer (2006) [Pubmed]
  22. Analysis of 3-sulfated and nonsulfated bile acids by one-step solvolysis and high performance liquid chromatography. Hirano, Y., Miyazaki, H., Higashidate, S., Nakayama, F. J. Lipid Res. (1987) [Pubmed]
  23. A simple method for the determination of lipid composition of human bile. Muraca, M., Vilei, M.T., Miconi, L., Petrin, P., Antoniutti, M., Pedrazzoli, S. J. Lipid Res. (1991) [Pubmed]
  24. Structural and functional comparison of two human liver dihydrodiol dehydrogenases associated with 3 alpha-hydroxysteroid dehydrogenase activity. Deyashiki, Y., Taniguchi, H., Amano, T., Nakayama, T., Hara, A., Sawada, H. Biochem. J. (1992) [Pubmed]
  25. Crystallization and preliminary X-ray crystallographic analysis of the human type 3 3 alpha-hydroxysteroid dehydrogenase at 1.8 A resolution. Zhu, D.W., Cantin, L., Nahoum, V., Rehse, P., Luu-The, V., Labrie, F., Breton, R., Lin, S.X. Acta Crystallogr. D Biol. Crystallogr. (2001) [Pubmed]
  26. Molecular cloning of human type 3 3 alpha-hydroxysteroid dehydrogenase that differs from 20 alpha-hydroxysteroid dehydrogenase by seven amino acids. Dufort, I., Soucy, P., Labrie, F., Luu-The, V. Biochem. Biophys. Res. Commun. (1996) [Pubmed]
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