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Chemical Compound Review

DQ-2556     (6R,7S)-7-[[(2Z)-2-(2-amino- 1,3-thiazol-4...

Synonyms: AC1NUP4U
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Disease relevance of (6R,7R)-7-[[(2E)-2-(2-aminothiazol-4-yl)-2-methoxyimino-acetyl]amino]-3-[(4-oxazol-5-yl-1-pyridyl)methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid


High impact information on (6R,7R)-7-[[(2E)-2-(2-aminothiazol-4-yl)-2-methoxyimino-acetyl]amino]-3-[(4-oxazol-5-yl-1-pyridyl)methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

  • The results of a protein-binding study by ultracentrifugation indicated that DQ-2556 was 20 to 30% bound to serum proteins in animals and its affinity was low [3].
  • When cells of E. coli were exposed to various concentrations of DQ-2556, filamentous cells were observed at concentrations of 0.0008 micrograms/ml and greater, spheroplasts started to form at 0.025 micrograms/ml, and subsequent cell lysis was observed [1].
  • DQ-2556 had no effect on brush border transport systems for organic anions or dipeptides and basolateral transport systems for organic cations or anions in dogs, rabbits and rats [4].
  • The MIC of DQ-2556 for Esch. coli increased four-fold in an OmpF-deficient mutant, indicating that the OmpF porin was one of the major routes for penetration of DQ-2556 into Esch. coli cells [5].
  • In the rabbit, the pharmacokinetics of DQ-2556 was linear even up to a dose of 1200 mg/kg and no unusual pharmacokinetic behavior was observed [6].

Biological context of (6R,7R)-7-[[(2E)-2-(2-aminothiazol-4-yl)-2-methoxyimino-acetyl]amino]-3-[(4-oxazol-5-yl-1-pyridyl)methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid


Associations of (6R,7R)-7-[[(2E)-2-(2-aminothiazol-4-yl)-2-methoxyimino-acetyl]amino]-3-[(4-oxazol-5-yl-1-pyridyl)methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid with other chemical compounds


Analytical, diagnostic and therapeutic context of (6R,7R)-7-[[(2E)-2-(2-aminothiazol-4-yl)-2-methoxyimino-acetyl]amino]-3-[(4-oxazol-5-yl-1-pyridyl)methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid


  1. In vitro and in vivo activities of DQ-2556 and its mode of action. Tanaka, M., Otsuki, M., Nishino, T. Antimicrob. Agents Chemother. (1992) [Pubmed]
  2. In vitro activity of DQ-2556, a new cephalosporin. Fujimoto, T., Otani, T., Nakajima, R., Une, T., Osada, Y. Antimicrob. Agents Chemother. (1986) [Pubmed]
  3. Metabolic disposition of DQ-2556, a new cephalosporin, in rats, rabbits, dogs, and monkeys. Matsubayashi, K., Shintani, S., Yoshioka, M., Tachizawa, H. Antimicrob. Agents Chemother. (1992) [Pubmed]
  4. Effect of DQ-2556, a new cephalosporin, on organic ion transport in renal plasma membrane vesicles from the dog, rabbit and rat. Sokol, P.P. J. Pharmacol. Exp. Ther. (1990) [Pubmed]
  5. In-vitro antibacterial activity of DQ-2556 and its stability to various beta-lactamases. Fujimoto, T., Watanabe, M., Inoue, M., Mitsuhashi, S. J. Antimicrob. Chemother. (1990) [Pubmed]
  6. Nonlinear pharmacokinetics of DQ-2556, a new 3-quaternary ammonium cephalosporin antibiotic, in rats caused by non-Michaelis-Menten type, dose-dependent renal clearance. Matsubayashi, K., Shintani, S., Yoshida, K., Yamada, M., Tachizawa, H. Journal of pharmaceutical sciences. (1994) [Pubmed]
  7. Nephrotoxicity of a new cephalosporin, DQ-2556, in rats. Kato, M., Yoshida, M., Shimada, H., Akahane, K., Takayama, S. Fundamental and applied toxicology : official journal of the Society of Toxicology. (1992) [Pubmed]
  8. Phase I study of DQ-2556, a new parenteral 3-quaternary ammonium cephalosporin antibiotic. Nakashima, M., Uematsu, T., Kanamaru, M., Mizuno, A., Matsubayashi, K., Okazaki, O., Hashimoto, S., Hakusui, H., Osada, Y. Journal of clinical pharmacology. (1993) [Pubmed]
  9. Simple method for determination of the cephalosporin DQ-2556 in biological fluids by high-performance liquid chromatography. Matsubayashi, K., Yoshioka, M., Tachizawa, H. J. Chromatogr. (1990) [Pubmed]
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