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Chemical Compound Review

Tremorine     1-(4-pyrrolidin-1-ylbut-2- ynyl)pyrrolidine

Synonyms: Tremorin, Biofermin, SureCN892987, BSPBio_000361, SPBio_002282, ...
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Disease relevance of Tremorine

  • In the dose range where the aforementioned effects were observed AY-23,028 did not antagonize either the tetrabenazine-induced ptosis or the tremorine syndrome and did not cause either hypothermia or ataxia [1].
  • Tremorine-induced tremors model is used to evaluate antiparkinsonian drugs because rest tremor is a sign that distinguishes Parkinson's disease (PD) from other diseases [2].
  • With tremorine tremor no such allometric correlation was found for tremor frequency and body weight (mice: 17.7 +/- 3.6 Hz; rats: 19.6 +/- 5.1 Hz; rabbits: 15.9 +/- 2.1 Hz) [3].
  • Comparative effects of antimicrobial and Biofermin T in the treatment of infantile diarrhea [4].

High impact information on Tremorine


Biological context of Tremorine

  • Administration of tremorine (25 mg/kg, ip) to saline-treated controls produced, within 2 or 3 min, tremors, piloerection, profuse salivation, defaecation, urination and chromodacryorrhesis (red tears) [7].
  • In the primary pharmacological screening and in the drug-interaction studies with reserpine, tetrabenazine, and tremorine, tandamine was compared to the clinically effective tricyclic antidepressants--desipramine, imipramine, and amitriptyline [8].
  • Administration of tremorine (25 mg/kg, i.p.) to control vehicle-treated rats produced within 2-3 min tremors, piloerection, profuse salivation, defecation urination and chromodacryorrhesis (red tears) [9].
  • Five times higher doses of tremorine than in normotensive rats were necessary to induce statistically significant increase in type I inhibitor activity in the posterior hypothalamus and brain stem suggesting subsensitivity of M2-muscarinic receptors in the brain areas responsible for the regulation of blood pressure [10].

Anatomical context of Tremorine


Associations of Tremorine with other chemical compounds

  • Reduction in 5-HT levels in brain by parachlorophenylalamine pretreatment decreased the ED50 of tremorine analgesia in tremorine tolerant mice [6].
  • The compound was more potent than either TRH or clinically established drugs in four animal tests of antidepressant potential (reserpine reversal, clonidine antagonism, tremorine reversal and learned immobility) [12].
  • Pimprinine also inhibited effectively tremorine-induced tremors and analgesia in mice [13].

Analytical, diagnostic and therapeutic context of Tremorine

  • In order to quantify the tremorine and cold tremor activity in unanesthetized rats, a new ultrasonic motion transducer method was used [14].


  1. The behavioral pharmacology of butaclamol hydrochloride (AY-23,028), a new potent neuroleptic drug. Voith, K., Herr, F. Psychopharmacologia. (1975) [Pubmed]
  2. Antiparkinsonian-like effects of Plumbago scandens on tremorine-induced tremors methodology. Morais, L.C., Quintans-Júnior, L.J., Franco, C.I., Almeida, J.R., Almeida, R.N. Pharmacol. Biochem. Behav. (2004) [Pubmed]
  3. Spectral analysis of tremorine and cold tremor electromyograms in animal species of different size. Günther, H., Brunner, R., Klussmann, F.W. Pflugers Arch. (1983) [Pubmed]
  4. Comparative effects of antimicrobial and Biofermin T in the treatment of infantile diarrhea. Munir, M., Mantik, M., Lukman, S. Paediatrica Indonesiana. (1985) [Pubmed]
  5. Effects of lesions in some basal ganglia nuclei and efferent projections on tremorine-induced limb rigidity in rats. Slater, P., Dickinson, S.L. Exp. Neurol. (1983) [Pubmed]
  6. Possible involvement of 5-hydroxytryptamine and cyclic-AMP in tolerance to tremorine analgesia in mice. Naik, S.R., Amladi, S.R., Sheth, U.K. Psychopharmacology (Berl.) (1977) [Pubmed]
  7. Effect of grapefruit juice on drug metabolism in rats. Sharif, S.I., Ali, B.H. Food Chem. Toxicol. (1994) [Pubmed]
  8. Syntheses and primary pharmacological screening of tandamine and related tetrahydrothiopyranoindoles with potential antidepressant properties. Jirkovsky, I., Humber, L.G., Voith, K., Charest, M.P. Arzneimittel-Forschung. (1977) [Pubmed]
  9. The effect of furazolidone and furaltadone on drug metabolism in rats. Ali, B.H., Tanira, M.O., Bashir, A.K. European journal of drug metabolism and pharmacokinetics. (1996) [Pubmed]
  10. The responsiveness of M2-muscarinic receptors in the posterior hypothalamus and brain stem of vasopressin hypertensive rats. Szmigielska, H., Szmigielski, A., Szadowska, A. Polish journal of pharmacology. (1993) [Pubmed]
  11. Effects of lesioning basal ganglia nuclei and output pathways on tremorine-induced tremor in rats. Slater, P., Dickinson, S.L. J. Neurol. Sci. (1982) [Pubmed]
  12. Neuropharmacological evaluation of RX 77368--a stabilised analogue of thyrotropin-releasing hormone (TRH). Metcalf, G., Dettmar, P.W., Fortune, D., Lynn, A.G., Tulloch, I.F. Regul. Pept. (1982) [Pubmed]
  13. Pimprinine, an extracellular alkaloid produced by Streptomyces CDRIL-312: fermentation, isolation and pharmacological activity. Naik, S.R., Harindran, J., Varde, A.B. J. Biotechnol. (2001) [Pubmed]
  14. Ultrasonic analysis of tremorine and cold tremor activity in unanesthetized rats. Young, C.W., Young, M.S., Lin, M.T. The Chinese journal of physiology. (1997) [Pubmed]
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