Disease relevance of Xylamine

• Characterization of xylamine binding to proteins of PC12 pheochromocytoma cells [1].

High impact information on Xylamine

• The IC50 values for inhibition of the contractile response to 3 microM NA were 1.58 microM for xylamine, 1.70 microM for amitriptyline and 2.57 microM for protriptyline [2].
• Xylamine is not a direct acting vasodilator on smooth muscle [3].
• The effect of xylamine on sympathetic neuroeffector transmission in rabbit isolated blood vessels was examined [3].
• Xylamine (10(-8) to 10(-6) M) caused a slowly progressing inhibition of the contractions of pulmonary artery evoked by electrical field stimulation [3].
• We propose that this Mr 54,000 protein 1) is a component of the catecholamine transporter, 2) is present in B9 cells but in a conformation that reduces transporter activity and makes alkylation by xylamine more likely, and 3) is absent in MPT1 cells [4].

Biological context of Xylamine

• The dose-dependent reduction of [3H]DA uptake by xylamine indicated competitive kinetics [5].
• However, xylamine lost the effect if the active transport inhibitor, ouabain or iodoacetate, was also incubated during the pretreatment period of if Na+ was absent [6].

Anatomical context of Xylamine

• Inhibition of [3H]norepinephrine uptake in organ cultured rat superior cervical ganglia by xylamine [7].
• However, the activity of Na+, K(+)-ATPase in synaptosomes was not modified by xylamine at concentrations sufficient to block the uptake of [3H]DA [5].
• The activity of Na(+)-K(+)-ATPase in astrocytes was not modified by xylamine at the concentrations sufficient to block the uptake of [3H]NE [6].
• Inhibition of contractions by tricyclic antidepressants and xylamine in rat vas deferens [8].
• Xylamine enhances pineal gland N-acetyltransferase activity in vitro [9].

Associations of Xylamine with other chemical compounds

• Incubation with 10 microM xylamine, an irreversible inhibitor of NE uptake, caused a small increase in [3H]NE efflux, but no reduction in the endogenous NE and dopamine levels in superior cervical ganglia [10].
• A series of neurochemical studies evaluated the selectivity of the depletions of norepinephrine produced by intraventricular injections of xylamine [11].
• 1. The action of N-2'-chloroethyl-N-ethyl-2-methyl benzylamine (xylamine) on rat pineal gland sympathetic innervation was examined [9].

Gene context of Xylamine

• A 1-hr pretreatment, but not a 24-hr pretreatment, with the monoamine oxidase B inhibitor, L-deprenyl (10 mg/kg ip), prevented the depletion of norepinephrine by xylamine [12].

Analytical, diagnostic and therapeutic context of Xylamine

• The effects of a chronic partial depletion of rat cortical NE by a single dose of xylamine (20 mg/kg i.p.) on pre- and postsynaptic noradrenergic functionality were studied 4 hr, 14, 21 and 35 days after treatment [13].
• Protriptyline, amitriptyline and xylamine concentration-dependently inhibited monophasic contractions induced by low frequency electrical stimulation (0.3 Hz, 1 ms duration, 60 V) [8].

References