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Chemical Compound Review

AG-K-67541     2-hydroxy-4-oxo-pentanedioic acid

Synonyms: CHEBI:30923, HMDB02070, AC1Q5BXC, CTK4B0908, AR-1K9994, ...
 
 
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Disease relevance of C01127

 

High impact information on C01127

 

Chemical compound and disease context of C01127

 

Biological context of C01127

 

Gene context of C01127

 

Analytical, diagnostic and therapeutic context of C01127

References

  1. Recovery of respiration following the SOS response of Escherichia coli requires RecA-mediated induction of 2-keto-4-hydroxyglutarate aldolase. Cayrol, C., Petit, C., Raynaud, B., Capdevielle, J., Guillemot, J.C., Defais, M. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  2. The complete amino acid sequence and identification of the active-site arginine peptide of Escherichia coli 2-keto-4-hydroxyglutarate aldolase. Vlahos, C.J., Dekker, E.E. J. Biol. Chem. (1988) [Pubmed]
  3. Evidence for an essential arginine residue in the active site of Escherichia coli 2-keto-4-hydroxyglutarate aldolase. Modification with 1,2-cyclohexanedione. Vlahos, C.J., Ghalambor, M.A., Dekker, E.E. J. Biol. Chem. (1985) [Pubmed]
  4. Malyl-CoA formation in the NAD-, CoASH-, and alpha-ketoglutarate dehydrogenase-dependent oxidation of 2-keto-4-hydroxyglutarate. Possible coupled role of this reaction with 2-keto-4-hydroxyglutarate aldolase activity in a pyruvate-catalyzed cyclic oxidation of glyoxylate. Gupta, S.C., Dekker, E.E. J. Biol. Chem. (1984) [Pubmed]
  5. Steady-state kinetics and inhibition studies of the aldol condensation reaction catalyzed by bovine liver and Escherichia coli 2-keto-4-hydroxyglutarate aldolase. Grady, S.R., Wang, J.K., Dekker, E.E. Biochemistry (1981) [Pubmed]
  6. Evidence for the identity and some comparative properties of alpha-ketoglutarate and 2-keto-4-hydroxyglutarate dehydrogenase activity. Gupta, S.C., Dekker, E.E. J. Biol. Chem. (1980) [Pubmed]
  7. Amino acid sequence of the pyruvate and the glyoxylate active-site lysine peptide of Escherichia coli 2-keto-4-hydroxyglutarate aldolase. Vlahos, C.J., Dekker, E.E. J. Biol. Chem. (1986) [Pubmed]
  8. Tritium exchange reactions catalyzed by 2-oxo-4-hydroxyglutarate aldolase from Escherichia coli K-12. Grady, S.R., Dekker, E.E. Biochim. Biophys. Acta (1979) [Pubmed]
  9. Cloning, nucleotide sequence, overexpression, and inactivation of the Escherichia coli 2-keto-4-hydroxyglutarate aldolase gene. Patil, R.V., Dekker, E.E. J. Bacteriol. (1992) [Pubmed]
  10. Dimerization occurs during the reversible acid inactivation of 2-oxo-4-hydroxyglutarate aldolase from Escherichia coli. Winter, H.C., Lewinski, N.D., Wang, J.K., Dekker, E.E. Biochim. Biophys. Acta (1983) [Pubmed]
  11. Regulation of rat liver 4-hydroxy-2-ketoglutarate aldolase. Scholtz, J.M., Schuster, S.M. Biochim. Biophys. Acta (1986) [Pubmed]
 
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