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Chemical Compound Review

AG-K-67541     2-hydroxy-4-oxo-pentanedioic acid

Synonyms: CHEBI:30923, HMDB02070, AC1Q5BXC, CTK4B0908, AR-1K9994, ...
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  1. Recovery of respiration following the SOS response of Escherichia coli requires RecA-mediated induction of 2-keto-4-hydroxyglutarate aldolase. Cayrol, C., Petit, C., Raynaud, B., Capdevielle, J., Guillemot, J.C., Defais, M. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  2. The complete amino acid sequence and identification of the active-site arginine peptide of Escherichia coli 2-keto-4-hydroxyglutarate aldolase. Vlahos, C.J., Dekker, E.E. J. Biol. Chem. (1988) [Pubmed]
  3. Evidence for an essential arginine residue in the active site of Escherichia coli 2-keto-4-hydroxyglutarate aldolase. Modification with 1,2-cyclohexanedione. Vlahos, C.J., Ghalambor, M.A., Dekker, E.E. J. Biol. Chem. (1985) [Pubmed]
  4. Malyl-CoA formation in the NAD-, CoASH-, and alpha-ketoglutarate dehydrogenase-dependent oxidation of 2-keto-4-hydroxyglutarate. Possible coupled role of this reaction with 2-keto-4-hydroxyglutarate aldolase activity in a pyruvate-catalyzed cyclic oxidation of glyoxylate. Gupta, S.C., Dekker, E.E. J. Biol. Chem. (1984) [Pubmed]
  5. Steady-state kinetics and inhibition studies of the aldol condensation reaction catalyzed by bovine liver and Escherichia coli 2-keto-4-hydroxyglutarate aldolase. Grady, S.R., Wang, J.K., Dekker, E.E. Biochemistry (1981) [Pubmed]
  6. Evidence for the identity and some comparative properties of alpha-ketoglutarate and 2-keto-4-hydroxyglutarate dehydrogenase activity. Gupta, S.C., Dekker, E.E. J. Biol. Chem. (1980) [Pubmed]
  7. Amino acid sequence of the pyruvate and the glyoxylate active-site lysine peptide of Escherichia coli 2-keto-4-hydroxyglutarate aldolase. Vlahos, C.J., Dekker, E.E. J. Biol. Chem. (1986) [Pubmed]
  8. Tritium exchange reactions catalyzed by 2-oxo-4-hydroxyglutarate aldolase from Escherichia coli K-12. Grady, S.R., Dekker, E.E. Biochim. Biophys. Acta (1979) [Pubmed]
  9. Cloning, nucleotide sequence, overexpression, and inactivation of the Escherichia coli 2-keto-4-hydroxyglutarate aldolase gene. Patil, R.V., Dekker, E.E. J. Bacteriol. (1992) [Pubmed]
  10. Dimerization occurs during the reversible acid inactivation of 2-oxo-4-hydroxyglutarate aldolase from Escherichia coli. Winter, H.C., Lewinski, N.D., Wang, J.K., Dekker, E.E. Biochim. Biophys. Acta (1983) [Pubmed]
  11. Regulation of rat liver 4-hydroxy-2-ketoglutarate aldolase. Scholtz, J.M., Schuster, S.M. Biochim. Biophys. Acta (1986) [Pubmed]
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