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Chemical Compound Review

BuCast     [(1S,6S,7S,8R,8aR)-1,7,8- trihydroxy-1,2,3...

Synonyms: Celgosivir, B-CAST, VIR-222, SureCN135812, MBI-3253, ...
 
 
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Disease relevance of B-CAST

 

High impact information on B-CAST

  • We now report that consistent with its improved anti-HIV activity, MDL 28,574 is more effective (50% inhibitory concentration [IC50], 20 microM) than the parent molecule (IC50, 254 microM) at causing the accumulation of glucosylated oligosaccharides in HIV-infected cells by inhibition of glycoprotein processing [6].
  • Previously, it has been shown that the alpha-glucose 1 inhibitor (MDL 28574) treatment of human leukocytes in vitro or mouse lymphocytes in vivo affects the detection of LFA-1 but not domain 1 of CD4 nor several other CD markers (Bridges et al., submitted for publication) [4].
  • The most effective analogue was 6-O-butanoyl CAST (B-CAST, MDL 28,574) with an IC50 of 0.05 micrograms/mL against MOLV [7].
 

Analytical, diagnostic and therapeutic context of B-CAST

References

  1. 6-0-butanoylcastanospermine (MDL 28,574) inhibits glycoprotein processing and the growth of HIVs. Taylor, D.L., Sunkara, P.S., Liu, P.S., Kang, M.S., Bowlin, T.L., Tyms, A.S. AIDS (1991) [Pubmed]
  2. The effect of oral treatment with 6-O-butanoyl castanospermine (MDL 28,574) in the murine zosteriform model of HSV-1 infection. Bridges, C.G., Ahmed, S.P., Kang, M.S., Nash, R.J., Porter, E.A., Tyms, A.S. Glycobiology (1995) [Pubmed]
  3. Antiviral activity and metabolism of the castanospermine derivative MDL 28,574, in cells infected with herpes simplex virus type 2. Ahmed, S.P., Nash, R.J., Bridges, C.G., Taylor, D.L., Kang, M.S., Porter, E.A., Tyms, A.S. Biochem. Biophys. Res. Commun. (1995) [Pubmed]
  4. The prevention of cell adhesion and the cell-to-cell spread of HIV-1 in vitro by the alpha-glucosidase 1 inhibitor, 6-O-butanoyl castanospermine (MDL 28574). Bridges, C.G., Brennan, T.M., Taylor, D.L., McPherson, M., Tyms, A.S. Antiviral Res. (1994) [Pubmed]
  5. Action of celgosivir (6 O-butanoyl castanospermine) against the pestivirus BVDV: implications for the treatment of hepatitis C. Whitby, K., Taylor, D., Patel, D., Ahmed, P., Tyms, A.S. Antivir. Chem. Chemother. (2004) [Pubmed]
  6. Inhibition of alpha-glucosidase I of the glycoprotein-processing enzymes by 6-O-butanoyl castanospermine (MDL 28,574) and its consequences in human immunodeficiency virus-infected T cells. Taylor, D.L., Kang, M.S., Brennan, T.M., Bridges, C.G., Sunkara, P.S., Tyms, A.S. Antimicrob. Agents Chemother. (1994) [Pubmed]
  7. Inhibition of glycoprotein processing and HIV replication by castanospermine analogues. Sunkara, P.S., Kang, M.S., Bowlin, T.L., Liu, P.S., Tyms, A.S., Sjoerdsma, A. Ann. N. Y. Acad. Sci. (1990) [Pubmed]
 
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