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Chemical Compound Review

ELEDOISIN     3-[1-[[1-[[1-[[1-[(1- aminocarbonyl-3...

Synonyms: Eledoisina, Eledoisine, Eledoisinum, ELD 950, AC1Q5KVT, ...
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Disease relevance of ELEDOISIN

  • Vagotomy did not change this reaction, whereas pretreatment with the ganglion blocker hexamethonium slightly enhanced the bronchoconstrictor action of E and SP [1].

High impact information on ELEDOISIN


Biological context of ELEDOISIN


Anatomical context of ELEDOISIN

  • It is concluded that SP and E cause contraction of detrusor by a direct effect on the smooth muscle cells, and that this response is dependent on the extracellular calcium concentration [6].
  • 1. Circumoesophageal ganglia and foot muscle of the garden snail, Helix aspersa, were subjected to immunocytochemistry using antisera to the tachykinins, substance P (SP), neurokinin A (NKA), kassinin (KAS) and eledoisin (ELE) [7].

Associations of ELEDOISIN with other chemical compounds

  • In the GPGB, the relative potencies were SK greater than KA greater than EL much greater than PH greater than SP, which is similar to that reported for the NK-2 receptor in radioligand binding assays [8].
  • In fact, on lamb and sheep bladder neurokinin A (NKA), a NK2- almost selective peptide, was shown to be > 100% more active than the natural tachykinins kassinin (KASS) and eledoisin (ELED) [9].
  • Both atropine and the 5-hydroxytryptamine antagonist methysergide largely reduced the bronchoconstriction induced by E and SP [1].


  1. The mechanism of tachykinin-induced bronchoconstriction in the rat. Joos, G.F., Pauwels, R.A., van der Straeten, M.E. Am. Rev. Respir. Dis. (1988) [Pubmed]
  2. alpha-Bungarotoxin interacts with the rat brain tachykinin receptors. Utkin YuN, n.u.l.l., Lazakovich, E.M., Kasheverov, I.E., Tsetlin, V.I. FEBS Lett. (1989) [Pubmed]
  3. Effects of neurokinins on the isolated pig coronary artery. Gulati, N., Mathison, R., Huggel, H., Regoli, D., Bény, J.L. Eur. J. Pharmacol. (1987) [Pubmed]
  4. Immunohistochemical and chromatographic studies of peptides with tachykinin-like immunoreactivity in the central nervous system of the lamprey. Van Dongen, P.A., Theodorsson-Norheim, E., Brodin, E., Hökfelt, T., Grillner, S., Peters, A., Cuello, A.C., Forssmann, W.G., Reinecke, M., Singer, E.A. Peptides (1986) [Pubmed]
  5. Tachykinin receptors mediating airway macromolecular secretion. Gentry, S.E. Life Sci. (1991) [Pubmed]
  6. Contractile effects of some polypeptides on the isolated urinary bladder of guinea-pig, rabbit, and rat. Sjögren, C., Andersson, K.E., Husted, S. Acta pharmacologica et toxicologica. (1982) [Pubmed]
  7. Immunochemical characterisation of tachykinin immunoreactivity in the nervous system of the garden snail, Helix aspersa. Leung, P.S., Shaw, C., Johnston, C.F., Irvine, G.B. Comp. Biochem. Physiol. C, Comp. Pharmacol. Toxicol. (1992) [Pubmed]
  8. A novel bioassay for the NK-2 neurokinin receptor: the guinea pig gallbladder. Shook, J.E., Burks, T.F. Life Sci. (1986) [Pubmed]
  9. Effects of natural tachykinins on ovine lower urinary tract smooth muscle. Tucci, P., Bolle, P., Severini, C. Journal of autonomic pharmacology. (2001) [Pubmed]
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