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Chemical Compound Review

Tavegyl     but-2-enedioic acid; (2R)-2-[2-[(1R)-1-(4...

Synonyms: Aloginan, Alphamin, Anhistan, Clemanil, Inbestan, ...
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Disease relevance of HS-592


Psychiatry related information on HS-592


High impact information on HS-592


Chemical compound and disease context of HS-592


Biological context of HS-592

  • There was a significant 21.9% increase in specific airways conductance after inhalation of clemastine [18].
  • In five of the ten patients aspirin-precipitated bronchoconstriction was also reduced or prevented after pretreatment with clemastine [19].
  • Clemastine was significantly better than placebo for both PEFR and FEV1 [1].
  • IHERG tails at -40 mV following depolarizing pulses to +20 mV were inhibited by clemastine with an IC50 value of 12 nM; this drug concentration also produced a marked inhibition of peak IHERG elicited during an AP voltage-clamp command [20].
  • The S6 point mutations Y652A and F656A greatly attenuated the inhibitory effect of clemastine [20].

Anatomical context of HS-592


Associations of HS-592 with other chemical compounds


Gene context of HS-592


Analytical, diagnostic and therapeutic context of HS-592


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