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Chemical Compound Review

lactitol     (2S,3R,4R,5R)-4- [(2R,3R,5R,6R)-3,4,5...

Synonyms: CCRIS 7077, LS-175929, NSC 231323, AC1L3M5J, C12H24O11, ...
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Disease relevance of lactitol


Psychiatry related information on lactitol

  • Fourteen patients with cirrhosis and subclinical hepatic encephalopathy were randomised to treatment with lactitol or lactulose for a 2-month period during which they were monitored clinically, by electroencephalography and by manually administered and computer-based psychometric testing [4].
  • An adequate catharsis was achieved with a mean (+/- 1 SD) equivalent daily dose of 31.9 +/- 11.2 g of lactitol or 32.9 +/- 16.7 ml (21.9 +/- 11.1 g) of lactulose syrup [5].

High impact information on lactitol


Chemical compound and disease context of lactitol


Biological context of lactitol


Anatomical context of lactitol

  • One of those, the disaccharide 4-gal-actosyl-sorbitol (lactitol), is only metabolized in the large intestine, where it is converted into acidic residues [14].
  • In the jejunum of animals fed the lactitol or tributyrin+lactitol diets, the length of the villi was increased by 12% (P < 0.05) compared to animals fed the control diet, whereas the tributyrin diet did not have any effect on the villi (P > 0.05) [19].
  • These findings indicate that lactitol is not absorbed by the human small intestine [20].
  • Combination of polydextrose and lactitol affects microbial ecosystem and immune responses in rat gastrointestinal tract [21].
  • In the cecum, the depths of the crypts were reduced (P < 0.001) by 18% in animals fed the lactitol diet and 45% in animals fed the tributyrin or tributyrin+lactitol diets compared to animals fed the control diet [19].

Associations of lactitol with other chemical compounds

  • RESULTS: Ammonia increased significantly after the glutamine load (from 83 +/- 13 to 164 +/- 30 microg/dl at 30 min and 210 +/- 29 microg/dl at 60 min; mean +/- SE; p = 0.006 analysis of variance) but not after glutamine load after lactitol treatment (from 77 +/- 17 to 111 +/- 21 microg/dl and 142 +/- 24 microg/dl; p = not significant) [11].
  • Here we describe the determination of maltitol, isomaltitol, and lactitol, along with other common carbohydrates, in some foodstuffs such as toffees, biscuits, creams, sponge cakes, chocolates, roasted malt, and chicory leaves [22].
  • Healthy human volunteers consumed lactitol or sucrose as a fruit-flavored drink [23].
  • In the second part of the study the laxative threshold of lactitol was determined and compared with that of sorbitol in a double-blind, randomized, cross-over study on twenty-one normal subjects [20].
  • Fermentation of lactitol and xylitol was only very slight, leaving the final pH high and leading to extremely low enamel demineralization figures [24].

Gene context of lactitol

  • Dietary lactitol fermentation increases circulating peptide YY and glucagon-like peptide-1 in rats and humans [23].
  • We studied the effects of a fermentable sugar-alcohol (lactitol) on the concentrations of enteroglucagon and gastrin in the blood of rats for 7.5 h after feeding [25].
  • Four RCTs were eligible for analysis; in three lactitol was compared to lactulose, in one the alternative treatment was lactose in lactase-deficient patients [26].

Analytical, diagnostic and therapeutic context of lactitol


  1. Lactitol or lactulose in the treatment of chronic hepatic encephalopathy: results of a meta-analysis. Blanc, P., Daures, J.P., Rouillon, J.M., Peray, P., Pierrugues, R., Larrey, D., Gremy, F., Michel, H. Hepatology (1992) [Pubmed]
  2. Effects of long-term administration of low-dose lactitol in patients with cirrhosis but without overt encephalopathy. Salerno, F., Moser, P., Maggi, A., Vitaliani, G., Benetti, G. J. Hepatol. (1994) [Pubmed]
  3. Bifidobacterium lactis Bb-12 and Lactobacillus salivarius UCC500 modify carboxylic acid formation in the hindgut of rats given pectin, inulin, and lactitol. Nilsson, U., Nyman, M., Ahrné, S., Sullivan, E.O., Fitzgerald, G. J. Nutr. (2006) [Pubmed]
  4. Lactitol and lactulose for the treatment of subclinical hepatic encephalopathy in cirrhotic patients. A randomised, cross-over study. Morgan, M.Y., Alonso, M., Stanger, L.C. J. Hepatol. (1989) [Pubmed]
  5. Lactitol versus lactulose in the treatment of chronic hepatic encephalopathy. A double-blind, randomised, cross-over study. Morgan, M.Y., Hawley, K.E., Stambuk, D. J. Hepatol. (1987) [Pubmed]
  6. Lactitol vs. lactulose in the treatment of acute hepatic encephalopathy in cirrhotic patients: a double-blind, randomized trial. Morgan, M.Y., Hawley, K.E. Hepatology (1987) [Pubmed]
  7. The trans-sialidase from Trypanosoma cruzi triggers apoptosis by target cell sialylation. Mucci, J., Risso, M.G., Leguizamón, M.S., Frasch, A.C., Campetella, O. Cell. Microbiol. (2006) [Pubmed]
  8. Comparison of rifaximin and lactitol in the treatment of acute hepatic encephalopathy: results of a randomized, double-blind, double-dummy, controlled clinical trial. Mas, A., Rodés, J., Sunyer, L., Rodrigo, L., Planas, R., Vargas, V., Castells, L., Rodríguez-Martínez, D., Fernández-Rodríguez, C., Coll, I., Pardo, A. J. Hepatol. (2003) [Pubmed]
  9. Lactose derivatives are inhibitors of Trypanosoma cruzi trans-sialidase activity toward conventional substrates in vitro and in vivo. Agustí, R., París, G., Ratier, L., Frasch, A.C., de Lederkremer, R.M. Glycobiology (2004) [Pubmed]
  10. Lactitol versus lactulose in the treatment of acute portal systemic encephalopathy (PSE). A controlled trial. Heredia, D., Caballería, J., Arroyo, V., Ravelli, G., Rodés, J. J. Hepatol. (1987) [Pubmed]
  11. Effect of lactitol on blood ammonia response to oral glutamine challenge in cirrhotic patients: evidence for an effect of nonabsorbable disaccharides on small intestine ammonia generation. Masini, A., Efrati, C., Merli, M., Attili, A.F., Amodio, P., Ceccanti, M., Riggio, O. Am. J. Gastroenterol. (1999) [Pubmed]
  12. Lactitol, a second-generation disaccharide for treatment of chronic portal-systemic encephalopathy. A double-blind, crossover, randomized clinical trial. Uribe, M., Toledo, H., Perez, F., Vargas, F., Gil, S., Garcia-Ramos, G., Ravelli, G.P., Guevara, L. Dig. Dis. Sci. (1987) [Pubmed]
  13. Latest state of research on lactitol and dental caries. Grenby, T.H. International dental journal. (1989) [Pubmed]
  14. Influence of the disaccharide lactitol on intestinal absorption and body retention of calcium in rats. Ammann, P., Rizzoli, R., Fleisch, H. J. Nutr. (1988) [Pubmed]
  15. Polydextrose, lactitol, and fructo-oligosaccharide fermentation by colonic bacteria in a three-stage continuous culture system. Probert, H.M., Apajalahti, J.H., Rautonen, N., Stowell, J., Gibson, G.R. Appl. Environ. Microbiol. (2004) [Pubmed]
  16. Hydrolysis of lactitol, maltitol and Palatinit by human intestinal biopsies. Nilsson, U., Jägerstad, M. Br. J. Nutr. (1987) [Pubmed]
  17. Bacterial translocation in the course of acute pancreatitis: beneficial role of nonabsorbable antibiotics and lactitol enemas. Marotta, F., Geng, T.C., Wu, C.C., Barbi, G. Digestion (1996) [Pubmed]
  18. Effect of one month of lactitol treatment on calcium metabolism in man. Egger, B., Arnera, V., Llull, J.B., Lauterburg, B.H. Eur. J. Clin. Pharmacol. (1989) [Pubmed]
  19. Tributyrin and lactitol synergistically enhanced the trophic status of the intestinal mucosa and reduced histamine levels in the gut of nursery pigs. Piva, A., Prandini, A., Fiorentini, L., Morlacchini, M., Galvano, F., Luchansky, J.B. J. Anim. Sci. (2002) [Pubmed]
  20. Lactitol, a new hydrogenated lactose derivative: intestinal absorption and laxative threshold in normal human subjects. Patil, D.H., Grimble, G.K., Silk, D.B. Br. J. Nutr. (1987) [Pubmed]
  21. Combination of polydextrose and lactitol affects microbial ecosystem and immune responses in rat gastrointestinal tract. Peuranen, S., Tiihonen, K., Apajalahti, J., Kettunen, A., Saarinen, M., Rautonen, N. Br. J. Nutr. (2004) [Pubmed]
  22. Determination of maltitol, isomaltitol, and lactitol by high-pH anion-exchange chromatography with pulsed amperometric detection. Cataldi, T.R., Campa, C., Casella, I.G., Bufo, S.A. J. Agric. Food Chem. (1999) [Pubmed]
  23. Dietary lactitol fermentation increases circulating peptide YY and glucagon-like peptide-1 in rats and humans. Gee, J.M., Johnson, I.T. Nutrition (Burbank, Los Angeles County, Calif.) (2005) [Pubmed]
  24. Studies of the dental properties of lactitol compared with five other bulk sweeteners in vitro. Grenby, T.H., Phillips, A., Mistry, M. Caries Res. (1989) [Pubmed]
  25. Fermentable carbohydrate modulates postprandial enteroglucagon and gastrin release in rats. Gee, J.M., Lee-Finglas, W., Johnson, I.T. Br. J. Nutr. (1996) [Pubmed]
  26. Lactitol in treatment of chronic hepatic encephalopathy. A meta-analysis. Cammà, C., Fiorello, F., Tinè, F., Marchesini, G., Fabbri, A., Pagliaro, L. Dig. Dis. Sci. (1993) [Pubmed]
  27. Lactitol tolerance in healthy Thai adults. Soontornchai, S., Sirichakwal, P., Puwastien, P., Tontisirin, K., Krüger, D., Grossklaus, R. European journal of nutrition. (1999) [Pubmed]
  28. Lactitol-based poly(ether polyol) hydrogels for controlled release chemical and drug delivery systems. Han, J.H., Krochta, J.M., Kurth, M.J., Hsieh, Y.L. J. Agric. Food Chem. (2000) [Pubmed]
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