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Chemical Compound Review

Bravelle     1-[[19-amino-7- (aminocarbonylmethyl)-13...

Synonyms: Fertinex, Metrodin, Urofollitropin, Fertinorm HP, AC1L1XUA, ...
 
 
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Disease relevance of Urofollitropin

  • From 1984 through 1991, chorionic gonadotropin, menotropins, and urofollitropin together accounted for no more than one third of the market share of the gonadotrophin class of drugs, whose primary indication is treatment of infertility [1].
  • Experience with recombinant FSH in the treatment of male hypogonadotrophic hypogonadism is limited, but the available data suggest that recombinant FSH has a similar efficacy to urine-derived preparations (urofollitropin) [2].
  • It remains unclear whether human menopausal gonadotropins have a higher risk of overstimulation and ovarian hyperstimulation syndrome compared to urofollitropin in women with polycystic ovary syndrome [3].
 

High impact information on Urofollitropin

  • OBJECTIVE: To determine the effects of ovarian stimulation with highly purified urofollitropin on oocyte and embryo quality [4].
  • This multicentre, open, randomized, study compared the efficacy and safety of recombinant follicle stimulating hormone (rFSH; follitropin alpha) with highly purified urinary human FSH (uFSH; urofollitropin HP) in women undergoing ovulation induction for assisted reproductive techniques [5].
  • OBJECTIVE: To assess the performance of Fertinex (urofollitropin; Serono Laboratories, Norwell, MA) in stimulating the development of multiple follicles and initiating subsequent pregnancy in patients undergoing controlled ovarian hyperstimulation (COH) for IVF [6].
  • Early follicular phase serum E2 and FSH changes in groups 1 and 2 were compared with changes in nine normal responder controls who were receiving a standard long-protocol GnRH-a/urofollitropin regimen (group 3) [7].
  • The relationship between FSH dose and serum level was different for lean and obese PCOS patients after subcutaneously injected urofollitropin CONCLUSIONS: There seems to be a difference in resorption/metabolism between lean and obese PCOS patients with regard to s.c. injected FSH [8].
 

Biological context of Urofollitropin

 

Anatomical context of Urofollitropin

 

Associations of Urofollitropin with other chemical compounds

 

Analytical, diagnostic and therapeutic context of Urofollitropin

References

  1. Use of fertility drugs in the United States, 1973 through 1991. Wysowski, D.K. Fertil. Steril. (1993) [Pubmed]
  2. Follicle-stimulating hormone in clinical practice: an update. Daya, S. Treatments in endocrinology. (2004) [Pubmed]
  3. Urofollitropin and ovulation induction. van Wely, M., Yding Andersen, C., Bayram, N., van der Veen, F. Treatments in endocrinology. (2005) [Pubmed]
  4. Effect of highly purified urinary follicle-stimulating hormone on oocyte and embryo quality. Selman, H.A., De Santo, M., Sterzik, K., Coccia, E., El-Danasouri, I. Fertil. Steril. (2002) [Pubmed]
  5. Induction of ovulation in women undergoing assisted reproductive techniques: recombinant human FSH (follitropin alpha) versus highly purified urinary FSH (urofollitropin HP). Lenton, E., Soltan, A., Hewitt, J., Thomson, A., Davies, W., Ashraf, N., Sharma, V., Jenner, L., Ledger, W., McVeigh, E. Hum. Reprod. (2000) [Pubmed]
  6. The performance of subcutaneously injected Fertinex when used as the sole gonadotropin for in vitro fertilization stimulation. Miller, K.A., Patton, G.W., Queenan, J.T. Fertil. Steril. (1998) [Pubmed]
  7. Clinical and endocrine effects of a microdose GnRH agonist flare regimen administered to poor responders who are undergoing in vitro fertilization. Surrey, E.S., Bower, J., Hill, D.M., Ramsey, J., Surrey, M.W. Fertil. Steril. (1998) [Pubmed]
  8. Serum FSH levels in women with polycystic ovary syndrome during ovulation induction using down-regulation and urofollitropin. Fridström, M., Sjöblom, P., Pousette, A., Hillensjö, T. Eur. J. Endocrinol. (1997) [Pubmed]
  9. Pharmacokinetics of recombinant human follicle stimulating hormone after intravenous, intramuscular, and subcutaneous administration in monkeys, and comparison with intravenous administration of urinary follicle stimulating hormone. Porchet, H.C., Le Cotonnec, J.Y., Canali, S., Zanolo, G. Drug Metab. Dispos. (1993) [Pubmed]
  10. Day 3 serum inhibin-B is predictive of assisted reproductive technologies outcome. Seifer, D.B., Lambert-Messerlian, G., Hogan, J.W., Gardiner, A.C., Blazar, A.S., Berk, C.A. Fertil. Steril. (1997) [Pubmed]
  11. Evolving patterns of iatrogenic multifetal pregnancy generation: implications for aggressiveness of infertility treatments. Evans, M.I., Littmann, L., St Louis, L., LeBlanc, L., Addis, J., Johnson, M.P., Moghissi, K.S. Am. J. Obstet. Gynecol. (1995) [Pubmed]
  12. Concentrations of insulin-like growth factor (IGF)-I and IGF binding protein-3 in the follicular fluid of women undergoing ovarian hyperstimulation with different gonadotropin preparations. Nardo, L.G., Bellanca, S.A., Burrello, N., Longo, G., D'Agata, R., Nardo, F., Calogero, A.E. Gynecol. Endocrinol. (2001) [Pubmed]
  13. Molecular composition of two different batches of urofollitropin: analysis by immunofluorimetric assay, radioligand receptor assay and in vitro bioassay. Simoni, M., Weinbauer, G.F., Nieschlag, E. J. Endocrinol. Invest. (1993) [Pubmed]
 
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