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Chemical Compound Review

UPCMLD-DP009     1H-quinazolin-4-one

Synonyms: SureCN10418, SureCN88525, CHEMBL266540, SureCN164234, NSC-5863, ...
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Disease relevance of NSC 5863


High impact information on NSC 5863


Associations of NSC 5863 with other chemical compounds


Gene context of NSC 5863

  • These compounds displayed micromolar affinities for CCK-B rather than CCK-A receptor and the obtained results confirm that the 4(3H)-quinazolinone nucleous represent a useful template for the development of selective CCK-B receptor ligands [8].
  • Synthesis and evaluation of substituted 4(3H)-quinazolone derivatives for antimicrobial and antiacetylcholinesterase activities. Part 3 [9].

Analytical, diagnostic and therapeutic context of NSC 5863


  1. Studies on standardization of folium strobilanthis, radix strobilanthis and their preparations. Li, L., Dong, T.Y., Li, X.L., Qian, C.Z. Biomed. Chromatogr. (1994) [Pubmed]
  2. Synthesis and in vitro antitumor activity of 4(3H)-quinazolinone derivatives with dithiocarbamate side chains. Cao, S.L., Feng, Y.P., Jiang, Y.Y., Liu, S.Y., Ding, G.Y., Li, R.T. Bioorg. Med. Chem. Lett. (2005) [Pubmed]
  3. Potent antimalarial febrifugine analogues against the plasmodium malaria parasite. Kikuchi, H., Tasaka, H., Hirai, S., Takaya, Y., Iwabuchi, Y., Ooi, H., Hatakeyama, S., Kim, H.S., Wataya, Y., Oshima, Y. J. Med. Chem. (2002) [Pubmed]
  4. Quinazoline antifolates inhibiting thymidylate synthase: 4-thio-substituted analogues. Thornton, T.J., Jones, T.R., Jackman, A.L., Flinn, A., O'Connor, B.M., Warner, P., Calvert, A.H. J. Med. Chem. (1991) [Pubmed]
  5. Regulation of kinase cascades and transcription factors by a poly(ADP-ribose) polymerase-1 inhibitor, 4-hydroxyquinazoline, in lipopolysaccharide-induced inflammation in mice. Veres, B., Radnai, B., Gallyas, F., Varbiro, G., Berente, Z., Osz, E., Sumegi, B. J. Pharmacol. Exp. Ther. (2004) [Pubmed]
  6. Combination effects of poly(ADP-ribose) polymerase inhibitors and DNA-damaging agents in ovarian tumor cell lines--with special reference to cisplatin. Bernges, F., Zeller, W.J. J. Cancer Res. Clin. Oncol. (1996) [Pubmed]
  7. Optical resolution of a series of potential cholecystokinin antagonist 4(3H)-quinazolone derivatives by chiral liquid chromatography on alpha1-acid glycoprotein stationary phase. Gyimesi-Forrás, K., Szász, G., Gergely, A., Szabó, M., Kökösi, J. Journal of chromatographic science. (2000) [Pubmed]
  8. Quinazolinone derivatives: synthesis and binding evaluation on cholecystokinin receptors. Varnavas, A., Lassiani, L., Luxich, E., Zacchigna, M., Boccù, E. Farmaco (1996) [Pubmed]
  9. Synthesis and evaluation of substituted 4(3H)-quinazolone derivatives for antimicrobial and antiacetylcholinesterase activities. Part 3. Misra, H.K., Sen Gupta, A.K. Die Pharmazie. (1982) [Pubmed]
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