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Chemical Compound Review

UPCMLD-DP128     3-aminobenzamide

Synonyms: Lopac-A-0788, Tocris-0788, CHEMBL81977, SureCN16070, S1132_Selleck, ...
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Disease relevance of CCRIS 3925


Psychiatry related information on CCRIS 3925


High impact information on CCRIS 3925

  • An insulator trap assay showed that the insulator function of most of these CTCF target sites is sensitive to 3-aminobenzamide, an inhibitor of poly(ADP-ribose) polymerase activity [7].
  • This effect could be reversed with the PARP inhibitor 3-aminobenzamide and did not occur in cells overexpressing a PARP-dead mutant of tankyrase 1 [8].
  • However, if the medium was supplemented with 3-aminobenzamide or nicotinamide, two compounds that inhibit poly(ADP-ribose) formation, cellular NAD+ and ATP pools were preserved, and the lymphocytes responded vigorously to a mitogenic challenge [9].
  • Inhibition by IFN-gamma (100-300 U/ml after 5-6 d) was, however, completely prevented by addition of two inhibitors of adenosine diphosphate-ribosyl transferase (ADP-RT), 3-aminobenzamide or nicotinamide [10].
  • This down-regulation effect of PARP-1 depended on NACP-Rep1 being present in the construct and was abrogated by inhibiting PARP-1's catalytic activity with 3-aminobenzamide [11].

Chemical compound and disease context of CCRIS 3925


Biological context of CCRIS 3925


Anatomical context of CCRIS 3925


Associations of CCRIS 3925 with other chemical compounds


Gene context of CCRIS 3925

  • Expression of UVDE in XRCC1-defective EM9, a Chinese hamster ovary cell line, greatly sensitizes the host cells to UV, and addition of 3-aminobenzamide results in almost no further sensitization of the cells to UV [27].
  • However, the presence of 3AB but not its analog suppressed radiation-induced accumulation of wtp53 and the expression of WAF1 and MDM2 [28].
  • Treatment with the PARP-1 inhibitors 3-aminobenzamide or 4-amino-1,8-naphthalimide during the insult improved HBMEC viability at 24 h after insult, and resulted in dose-dependent reductions in TUNEL-positivity at 16 h after insult, but not if these treatments were delayed by 4 h [29].
  • We demonstrated that specific inhibition of poly(ADP-ribose) polymerase activity via 3-aminobenzamide (3ABA) or NAD+ deprivation prevents FGF2-mediated uPA mRNA over-expression and cell-associated plasminogen activator (PA) production in GM7373 endothelial cell line [30].
  • The aim of the present study was to examine the effects of 3-aminobenzamide (3-AB), an inhibitor of PARP activity, in the development of acute pancreatitis caused by cerulein in mice [31].

Analytical, diagnostic and therapeutic context of CCRIS 3925


  1. Asbestos induces apoptosis of human and rabbit pleural mesothelial cells via reactive oxygen species. Broaddus, V.C., Yang, L., Scavo, L.M., Ernst, J.D., Boylan, A.M. J. Clin. Invest. (1996) [Pubmed]
  2. Targeted disruption of FANCC and FANCG in human cancer provides a preclinical model for specific therapeutic options. Gallmeier, E., Calhoun, E.S., Rago, C., Brody, J.R., Cunningham, S.C., Hucl, T., Gorospe, M., Kohli, M., Lengauer, C., Kern, S.E. Gastroenterology (2006) [Pubmed]
  3. Inhibition of the activity of poly(ADP ribose) synthetase reduces ischemia-reperfusion injury in the heart and skeletal muscle. Thiemermann, C., Bowes, J., Myint, F.P., Vane, J.R. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  4. Role of poly-ADP ribosyltransferase activation in the vascular contractile and energetic failure elicited by exogenous and endogenous nitric oxide and peroxynitrite. Szabó, C., Zingarelli, B., Salzman, A.L. Circ. Res. (1996) [Pubmed]
  5. Increased repair replication in human lymphoid cells by inhibition of polyadenosine diphosphoribose synthesis with no increase in patch sizes. Cleaver, J.E. Cancer Res. (1985) [Pubmed]
  6. Protection by 3-aminobenzamide and nicotinamide against streptozotocin-induced beta-cell toxicity in vivo and in vitro. Masiello, P., Novelli, M., Fierabracci, V., Bergamini, E. Res. Commun. Chem. Pathol. Pharmacol. (1990) [Pubmed]
  7. Poly(ADP-ribosyl)ation regulates CTCF-dependent chromatin insulation. Yu, W., Ginjala, V., Pant, V., Chernukhin, I., Whitehead, J., Docquier, F., Farrar, D., Tavoosidana, G., Mukhopadhyay, R., Kanduri, C., Oshimura, M., Feinberg, A.P., Lobanenkov, V., Klenova, E., Ohlsson, R. Nat. Genet. (2004) [Pubmed]
  8. TIN2 is a tankyrase 1 PARP modulator in the TRF1 telomere length control complex. Ye, J.Z., de Lange, T. Nat. Genet. (2004) [Pubmed]
  9. Lymphocyte dysfunction after DNA damage by toxic oxygen species. A model of immunodeficiency. Carson, D.A., Seto, S., Wasson, D.B. J. Exp. Med. (1986) [Pubmed]
  10. Inhibition of tumor cell growth by interferon-gamma is mediated by two distinct mechanisms dependent upon oxygen tension: induction of tryptophan degradation and depletion of intracellular nicotinamide adenine dinucleotide. Aune, T.M., Pogue, S.L. J. Clin. Invest. (1989) [Pubmed]
  11. Regulation of alpha-synuclein expression by poly (ADP ribose) polymerase-1 (PARP-1) binding to the NACP-Rep1 polymorphic site upstream of the SNCA gene. Chiba-Falek, O., Kowalak, J.A., Smulson, M.E., Nussbaum, R.L. Am. J. Hum. Genet. (2005) [Pubmed]
  12. Protection against myocardial ischemia and reperfusion injury by 3-aminobenzamide, an inhibitor of poly (ADP-ribose) synthetase. Zingarelli, B., Cuzzocrea, S., Zsengellér, Z., Salzman, A.L., Szabó, C. Cardiovasc. Res. (1997) [Pubmed]
  13. Peroxynitrite-induced oligodendrocyte toxicity is not dependent on poly(ADP-ribose) polymerase activation. Scott, G.S., Virág, L., Szabó, C., Hooper, D.C. Glia (2003) [Pubmed]
  14. Involvement of peroxynitrite and hydroxyradical generated from nitric oxide in hypoxia/reoxygenation injury in rat cerebrocortical slices. Oka, M., Hirouchi, M., Itoh, Y., Ukai, Y. Neuropharmacology (2000) [Pubmed]
  15. Enhancement of viral and DNA mediated transformation of cloned rat embryo fibroblast cells by 3-aminobenzamide. Su, Z.Z., Zhang, P.Q., Fisher, P.B. Mol. Carcinog. (1990) [Pubmed]
  16. Signal transduction pathways in the induction of 2',5'-oligoadenylate synthetase gene expression by interferon alpha/beta. Yan, C., Sehgal, P.B., Tamm, I. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
  17. Accumulation of 10-kilobase DNA replication intermediates in cells treated with 3-aminobenzamide. Lönn, U., Lönn, S. Proc. Natl. Acad. Sci. U.S.A. (1985) [Pubmed]
  18. Immunofluorescent staining of poly(ADP-ribose) in situ in HeLa cell chromosomes in the M phase. Kanai, Y., Tanuma, S., Sugimura, T. Proc. Natl. Acad. Sci. U.S.A. (1981) [Pubmed]
  19. Hydrogen peroxide decreases pHi in human aortic endothelial cells by inhibiting Na+/H+ exchange. Hu, Q., Xia, Y., Corda, S., Zweier, J.L., Ziegelstein, R.C. Circ. Res. (1998) [Pubmed]
  20. Toxicity of 3-aminobenzamide to Chinese hamster cells containing 5-hydroxymethyluracil in their DNA. Boorstein, R.J., Levy, D.D., Teebor, G.W. Cancer Res. (1987) [Pubmed]
  21. Genetic disruption of poly (ADP-ribose) synthetase inhibits the expression of P-selectin and intercellular adhesion molecule-1 in myocardial ischemia/reperfusion injury. Zingarelli, B., Salzman, A.L., Szabó, C. Circ. Res. (1998) [Pubmed]
  22. 11,12-Epoxyeicosatrienoic acid stimulates endogenous mono-ADP-ribosylation in bovine coronary arterial smooth muscle. Li, P.L., Chen, C.L., Bortell, R., Campbell, W.B. Circ. Res. (1999) [Pubmed]
  23. Effect of 3-aminobenzamide on the rate of ligation during repair of alkylated DNA in human fibroblasts. Morgan, W.F., Cleaver, J.E. Cancer Res. (1983) [Pubmed]
  24. X-ray repair cross-complementing gene I protein plays an important role in camptothecin resistance. Park, S.Y., Lam, W., Cheng, Y.C. Cancer Res. (2002) [Pubmed]
  25. Human nuclear NAD+ ADP-ribosyltransferase: localization of the gene on chromosome 1q41-q42 and expression of an active human enzyme in Escherichia coli. Herzog, H., Zabel, B.U., Schneider, R., Auer, B., Hirsch-Kauffmann, M., Schweiger, M. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
  26. Inhibition of poly(ADP-ribosyl)ation introduces an anomalous methylation pattern in transfected foreign DNA. Zardo, G., Marenzi, S., Perilli, M., Caiafa, P. FASEB J. (1999) [Pubmed]
  27. Cellular responses and repair of single-strand breaks introduced by UV damage endonuclease in mammalian cells. Okano, S., Kanno, S., Nakajima, S., Yasui, A. J. Biol. Chem. (2000) [Pubmed]
  28. Poly(ADP-ribosyl)ation is required for p53-dependent signal transduction induced by radiation. Wang, X., Ohnishi, K., Takahashi, A., Ohnishi, T. Oncogene (1998) [Pubmed]
  29. Cerebral endothelial cell apoptosis after ischemia-reperfusion: role of PARP activation and AIF translocation. Zhang, Y., Zhang, X., Park, T.S., Gidday, J.M. J. Cereb. Blood Flow Metab. (2005) [Pubmed]
  30. FGF2-mediated upregulation of urokinase-type plasminogen activator expression requires a MAP-kinase dependent activation of poly(ADP-ribose) polymerase. Caldini, R., Barletta, E., Del Rosso, M., Giovannelli, L., Chevanne, M. J. Cell. Physiol. (2005) [Pubmed]
  31. Effects of 3-aminobenzamide, an inhibitor of poly (ADP-ribose) polymerase, in a mouse model of acute pancreatitis induced by cerulein. Mazzon, E., Genovese, T., Di Paola, R., Mui??, C., Crisafulli, C., Malleo, G., Esposito, E., Meli, R., Sessa, E., Cuzzocrea, S. Eur. J. Pharmacol. (2006) [Pubmed]
  32. Purification and characterization of poly (ADP-ribose) synthetase from human placenta. Ushiro, H., Yokoyama, Y., Shizuta, Y. J. Biol. Chem. (1987) [Pubmed]
  33. Amelioration of diabetes mellitus in partially depancreatized rats by poly(ADP-ribose) synthetase inhibitors. Evidence of islet B-cell regeneration. Yonemura, Y., Takashima, T., Miwa, K., Miyazaki, I., Yamamoto, H., Okamoto, H. Diabetes (1984) [Pubmed]
  34. Potentiation of DNA damage by inhibition of poly(ADP-ribosyl)ation: a test of the hypothesis for random nuclease action. Rufer, J.T., Morgan, W.F. Exp. Cell Res. (1992) [Pubmed]
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