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Chemical Compound Review

CPD-13501     aminomethanedithioate

Synonyms: CTK1D6938, AC1MI2C8, 4384-82-1, Dithiocarbamate, Carbamodithioate, ...
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Disease relevance of aminomethanedithioic acid


High impact information on aminomethanedithioic acid


Chemical compound and disease context of aminomethanedithioic acid


Biological context of aminomethanedithioic acid


Anatomical context of aminomethanedithioic acid


Associations of aminomethanedithioic acid with other chemical compounds


Gene context of aminomethanedithioic acid


Analytical, diagnostic and therapeutic context of aminomethanedithioic acid

  • In vivo spin trapping with dithiocarbamate-iron complexes indicated that a significant amount of NO was generated in the virus-infected lung [32].
  • Isolated rat hearts were subjected either to normal perfusion or to reperfusion after 30 min of ischemia in the presence of the NO. trap Fe2+-N-methyl-D-glucamine dithiocarbamate with electron paramagnetic resonance measurements performed on the effluent [33].
  • HPLC/thermospray-MS and HPLC/UV photodiode-array analysis of CS2-dipeptide adducts confirmed dithiocarbamate formation and demonstrated their conversion into N-alkylisothiocyanates and, ultimately, N,N'-disubstituted thioureas and ureas [34].
  • In a crossover study, urinary dithiocarbamate excretion increased sharply after administration of broccoli sprout glucosinolates or isothiocyanates [35].
  • The S-methyl mono- and dithiocarbamate metabolites of these herbicides and fungicides are easily identified by retention time on gas chromatography and by mass spectrometry giving [MH]+ plus [R1R2NCO]+ or [R1R2NCS]+, respectively, as the two major ions [36].


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  19. Chronic treatment with agents that stabilize cytosolic IkappaB-alpha enhances survival and improves resting membrane potential in MDX muscle fibers subjected to chronic passive stretch. Carlson, C.G., Samadi, A., Siegel, A. Neurobiol. Dis. (2005) [Pubmed]
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  21. Peroxynitrite increases iNOS through NF-kappaB and decreases prostacyclin synthase in endothelial cells. Cooke, C.L., Davidge, S.T. Am. J. Physiol., Cell Physiol. (2002) [Pubmed]
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  23. TNF-alpha-induced cyclooxygenase-2 expression in human lung epithelial cells: involvement of the phospholipase C-gamma 2, protein kinase C-alpha, tyrosine kinase, NF-kappa B-inducing kinase, and I-kappa B kinase 1/2 pathway. Chen, C.C., Sun, Y.T., Chen, J.J., Chiu, K.T. J. Immunol. (2000) [Pubmed]
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  25. Redox cycling of iron complexes of N-(dithiocarboxy)sarcosine and N-methyl-D-glucamine dithiocarbamate. Lu, C., Koppenol, W.H. Free Radic. Biol. Med. (2005) [Pubmed]
  26. Substitution of the urease active site carbamate by dithiocarbamate and vanadate. Yamaguchi, K., Hausinger, R.P. Biochemistry (1997) [Pubmed]
  27. In vitro evaluation of BO-3482, a novel dithiocarbamate carbapenem with activity against methicillin-resistant staphylococci. Adachi, Y., Nakamura, K., Kato, Y., Hazumi, N., Hashizume, T., Nakagawa, S. Antimicrob. Agents Chemother. (1997) [Pubmed]
  28. Increase of cyclooxygenase-2 expression by interleukin 15 in rheumatoid synoviocytes. Min, S.Y., Hwang, S.Y., Jung, Y.O., Jeong, J., Park, S.H., Cho, C.S., Kim, H.Y., Kim, W.U. J. Rheumatol. (2004) [Pubmed]
  29. Involvement of p38 MAPK, JNK, p42/p44 ERK and NF-kappaB in IL-1beta-induced chemokine release in human airway smooth muscle cells. Wuyts, W.A., Vanaudenaerde, B.M., Dupont, L.J., Demedts, M.G., Verleden, G.M. Respiratory medicine. (2003) [Pubmed]
  30. Electron paramagnetic resonance spectroscopy with N-methyl-D-glucamine dithiocarbamate iron complexes distinguishes nitric oxide and nitroxyl anion in a redox-dependent manner: applications in identifying nitrogen monoxide products from nitric oxide synthase. Xia, Y., Cardounel, A.J., Vanin, A.F., Zweier, J.L. Free Radic. Biol. Med. (2000) [Pubmed]
  31. 2-mercaptoethanol restores the ability of nuclear factor kappa B (NF kappa B) to bind DNA in nuclear extracts from interleukin 1-treated cells incubated with pyrollidine dithiocarbamate (PDTC). Evidence for oxidation of glutathione in the mechanism of inhibition of NF kappa B by PDTC. Brennan, P., O'Neill, L.A. Biochem. J. (1996) [Pubmed]
  32. Pathogenesis of influenza virus-induced pneumonia: involvement of both nitric oxide and oxygen radicals. Akaike, T., Noguchi, Y., Ijiri, S., Setoguchi, K., Suga, M., Zheng, Y.M., Dietzschold, B., Maeda, H. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  33. Measurement of nitric oxide and peroxynitrite generation in the postischemic heart. Evidence for peroxynitrite-mediated reperfusion injury. Wang, P., Zweier, J.L. J. Biol. Chem. (1996) [Pubmed]
  34. Characterization of isothiocyanates, thioureas, and other lysine adduction products in carbon disulfide-treated peptides and protein. DeCaprio, A.P., Spink, D.C., Chen, X., Fowke, J.H., Zhu, M., Bank, S. Chem. Res. Toxicol. (1992) [Pubmed]
  35. Chemoprotective glucosinolates and isothiocyanates of broccoli sprouts: metabolism and excretion in humans. Shapiro, T.A., Fahey, J.W., Wade, K.L., Stephenson, K.K., Talalay, P. Cancer Epidemiol. Biomarkers Prev. (2001) [Pubmed]
  36. S-methylation as a bioactivation mechanism for mono- and dithiocarbamate pesticides as aldehyde dehydrogenase inhibitors. Staub, R.E., Sparks, S.E., Quistad, G.B., Casida, J.E. Chem. Res. Toxicol. (1995) [Pubmed]
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