Disease relevance of Common Cold

• WIN 51711 and WIN 52084 are structurally related, antiviral compounds that inhibit the replication of rhino (common cold) viruses and related picornaviruses [1].
• A multicentric trial compared the effect of chlorpheniramine maleate with a placebo on the signs and symptoms of the common cold [2].
• We have assessed the efficacy of co-amoxiclav in patients with common colds but no clinical signs of sinusitis or other indications for antibiotics [3].
• Huh7 cells were found to be susceptible to both SARS-CoV, associated with SARS, and human coronavirus 229E (HCoV-229E), usually associated with the common cold [4].
• Relationship of pleconaril susceptibility and clinical outcomes in treatment of common colds caused by rhinoviruses [5].

Psychiatry related information on Common Cold

• Physical activity and the common cold in men administered vitamin E and beta-carotene [6].
• CONCLUSION: Evidence supports use of zinc gluconate lozenges for reducing the symptoms and duration of the common cold, but the side effects, bad taste, and therapeutic protocol might limit patient compliance [7].
• Psychological stress and the common cold: Cohen et al. (1991) [8].

High impact information on Common Cold

• Vitamin C and the common cold [9].
• Zinc gluconate lozenges for treating the common cold in children: a randomized controlled trial [10].
• The structure of the 2A proteinase from a common cold virus: a proteinase responsible for the shut-off of host-cell protein synthesis [11].
• Effectiveness and safety of intranasal ipratropium bromide in common colds. A randomized, double-blind, placebo-controlled trial [12].
• Human clinical trials are under way to test the usefulness of bradykinin receptor antagonists to treat symptoms of the common cold and the pain associated with severe burns [13].

Chemical compound and disease context of Common Cold

• Evaluations by both patients and physicians showed that chlorpheniramine maleate was superior to placebo in lessening the degree of symptoms of the common cold [2].
• CONCLUSION: A low concentration of zinc sulfate nasal spray had no effect on the duration of the common cold [14].
• The common cold: effects of intranasal fluticasone propionate treatment [15].
• OBJECTIVE: We tested the hypothesis that changes in steroid responsiveness are implicated in the relationship between asthma and the common cold [16].
• L-Ascorbic acid and D-isoascorbic acid in a common cold survey [17].

Biological context of Common Cold

• Furthermore, individuals with a combination of IL2, IL6 and ICAM-1 polymorphisms tended to have higher frequencies of reported common colds than individuals with the alternate genotypes [18].
• Pulmonary function variables (forced expiratory flows and vital capacity, static lung volume, alveolar N2 slope, closing volume and closing capacity) were compared in a group of 10-16 year old children with (n = 65) and without (n = 440) symptoms or signs of mild acute respiratory infection ('common cold') [19].
• This review proposes a hypothesis; that acute cooling of the body surface causes reflex vasoconstriction in the nose and upper airways, and that this vasoconstrictor response may inhibit respiratory defence and cause the onset of common cold symptoms by converting an asymptomatic subclinical viral infection into a symptomatic clinical infection [20].
• Double blind trial in general practice comparing the efficacy of "Benylin Day and Night" and paracetamol in the treatment of the common cold [21].
• Local hyperthermia or inhalation of heated water vapor is often recommended as a home remedy for various nasal disorders such as the common cold and allergic rhinitis [22].

Anatomical context of Common Cold

• CONCLUSION: We conclude that an RV16 common cold in atopic asthmatic subjects is associated with increased ICAM-1 expression in the bronchial epithelium, which is not related to epithelial intactness [23].
• CONCLUSIONS: Common cold symptoms after nasal HRV 16 inoculation are associated with increased nasal mucosal output of eotaxin, suggesting that this chemokine is partly responsible for recruitment/activation of airway mucosal eosinophils in common cold infections [24].
• Vitamin C, neutrophils and the symptoms of the common cold [25].
• Effectiveness of pseudoephedrine plus acetaminophen for treatment of symptoms attributed to the paranasal sinuses associated with the common cold [26].
• Effects of rhinovirus-induced common colds on granulocyte activity in allergic rhinitis [27].

Gene context of Common Cold

• The subjects who developed common cold had increased NAL fluid levels of IFN gamma (P < 0.05) that correlated well with the symptoms (P < 0.001) [28].
• Frequency of common colds and serum levels of sICAM-1 (CD54), sLFA-3 (CD58) and sIL-2R (CD25) [29].
• GM-CSF was not detected in common cold [28].
• Neutralization of a common cold virus by concatemers of the third ligand binding module of the VLDL-receptor strongly depends on the number of modules [30].
• Acute phase response of serum amyloid A protein and C reactive protein to the common cold and influenza [31].

Analytical, diagnostic and therapeutic context of Common Cold

• A prospective, randomized, double-blind study was carried out to determine whether vitamin C prophylaxis, 2.0 g/day, vs placebo prophylaxis would reduce the incidence or morbidity of the common cold and other respiratory illnesses in 674 marine recruits during an eight-week period [32].
• Local hyperthermia is effective in reducing the symptoms of the common cold and perennial and seasonal allergic rhinitis, nasal patency also being improved in rhinitis [33].
• Intake of vitamin C and zinc and risk of common cold: a cohort study [34].
• RESULTS: The total symptom score, the duration of common cold episodes, and days with fever during an episode were lower in the probiotic-treated group than in the control group: 79.3+/-7.4 vs. 102.5+/-12.2 points (P = 0.056), 7.0+/-0.5 vs. 8.9+/-1.0 days (P = 0.045), 0.24+/-0.1 vs. 1.0+/-0.3 days (P = 0.017) [35].
• Lavage fluid levels of eotaxin were increased at the height of active common cold (day 4 after inoculation) both at baseline (after diluent challenge) (P<0.01) and acutely after allergen challenge (P<0.05) [24].

References