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Chemical Compound Review

Pentacin     calcium trisodium 2-[2-[2...

Synonyms: Pentacine, Penthamil, Ditripentat, AN-DTPA, Ca-DTPA, ...
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Disease relevance of Detapac

  • Weekly treatment with Ca-DTPA reduced the total Pu burden significantly, but these dogs also died with osteosarcoma between 1462 and 1783 days [1].
  • Ca-DTPA-induced fetal death and malformation in mice [2].
  • No pulmonary pathology was found from the single inhalation treatment with Ca-DTPA while only a slight, peripheral, histiocytosis was observed in the lungs of multiple-treated rats [3].
  • Prompt treatment with 100 mumol Ca-DTPA/kg body weight diminished the skeletal 234Th content by about 70%; but when it was delayed by 6 h or 4 d, the 234Th content was reduced by only about 20% and 10%, respectively [4].
  • Estimated toxicity of Ca-DTPA to the human fetus [5].

High impact information on Detapac


Biological context of Detapac

  • Female rats were given a single or 12 daily, 2-4 h, inhalation exposures to aerosols of 10, 20 and 40% Ca-DTPA and the lungs were examined at 21 and 42 days following the last exposure [3].

Analytical, diagnostic and therapeutic context of Detapac


  1. Effectiveness of DTPA treatments following the injection of particulate plutonium. Bruenger, F.W., Taylor, D.M., Taylor, G.N., Lloyd, R.D. Int. J. Radiat. Biol. (1991) [Pubmed]
  2. Ca-DTPA-induced fetal death and malformation in mice. Fisher, D.R., Calder, S.E., Mays, C.W., Taylor, G.N. Teratology (1976) [Pubmed]
  3. Early effects of inhaled Ca-DTPA on the rat lung. Smith, V.H., Dagle, G.E., Gelman, R.A., Ragan, H.A. Toxicol. Lett. (1980) [Pubmed]
  4. Comparison of Ca-DTPA and Zn-DTPA in removing 234Th from the rat. Peter-Witt, E., Volf, V. Health physics. (1985) [Pubmed]
  5. Estimated toxicity of Ca-DTPA to the human fetus. Mays, C.W., Taylor, G.N., Fisher, D.R. Health physics. (1976) [Pubmed]
  6. Metabolism of americium-241 in man: an unusual case of internal contamination of a child and his father. Cohen, N., Sasso, T.L., Wrenn, M.E. Science (1979) [Pubmed]
  7. 59Fe release from alveolar macrophages ingested 59Fe-iron dextran--enhancement by combination of Ca-DTPA and macrophage activating substances. Sato, H., Kubota, Y., Takahashi, S., Matsuoka, O. J. Radiat. Res. (1986) [Pubmed]
  8. On the influence of Ca-DTPA on delta-aminolevulinic acid dehydratase in rats. Planas-Bohne, F. Experientia (1977) [Pubmed]
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