Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Chemical Compound Review:

Prestwick_716 (2S)-4-amino-N-[5-amino-2-[4- amino-3,5...

Synonyms: SPBio_002530, AC1O3QTZ, A823716, 37517-28-5, Prestwick0_000395, ...

Shmara, A. et al., Miyata, T. et al., Yamamura, S. et al., Dar, J.A. et al.

Yamamura, Takehira, Kawada, Nishizawa, Katayama, Hirano, Momose, Dar, Thoker, Khan, Ali, Khan, Rizwan, Bhat, Dar, Ahmed, Ahmad,

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of amikacin

In one of the experiments, plasmid pJMR1O from Staphylococcus aureus coding for ampicillin (A), gentamicin (G) and amikacin (Ak) resistance was transformed into Escherichia coli [1].

High impact information on amikacin

These phenotypes, taken together with previous results indicating that mutant F171L could not catalyze acetylation of AMK when the assays were carried out at 42 degrees C (D. Panaite and M. Tolmasky, Plasmid 39:123-133, 1998), suggest that some motif B amino acids play a direct or indirect role in acceptor substrate specificity [2].
Three-layer ANN modelling and multivariate logistic regression analysis were used to predict the plasma concentrations of the aminoglycosides (ABK and AMK) in the severely ill patients [3].
In this study, we examined the effects of antibiotics on chemotaxis and phagocytosis by reacting macrophages with 7 different antibiotics, specifically ampicillin (ABPC), cephalexin (CEX), cefotiam (CTM), amikacin (AMK), clindamycin (CLDM), tetracycline (TC) and bleomycin (BLM) [4].

References

Molecular epidemiology of clinical and carrier strains of methicillin resistant Staphylococcus aureus (MRSA) in the hospital settings of north India. Dar, J.A., Thoker, M.A., Khan, J.A., Ali, A., Khan, M.A., Rizwan, M., Bhat, K.H., Dar, M.J., Ahmed, N., Ahmad, S. Ann. Clin. Microbiol. Antimicrob. (2006) [Pubmed]
Systematic analysis of a conserved region of the aminoglycoside 6'-N-acetyltransferase type Ib. Shmara, A., Weinsetel, N., Dery, K.J., Chavideh, R., Tolmasky, M.E. Antimicrob. Agents Chemother. (2001) [Pubmed]
Application of artificial neural network modelling to identify severely ill patients whose aminoglycoside concentrations are likely to fall below therapeutic concentrations. Yamamura, S., Takehira, R., Kawada, K., Nishizawa, K., Katayama, S., Hirano, M., Momose, Y. Journal of clinical pharmacy and therapeutics. (2003) [Pubmed]
Effect of antibiotics on rat leukocyte function. Miyata, T., Shinohara, M. Journal of Osaka Dental University. (1998) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

Editor

Share