Disease relevance of oxalic acid

• Apart from some practical limitations in data-handling facilities, we believe that PLS regression offers a promising tool for routine quantification, not only for whewellite, weddellite, and carbonate apatite, but also for other compositions of the urinary calculus [1].
• In addition to the phenomenological demonstration of Weddellite crystal shapes, incubation experiments with different solutions give rise to the postulation of a dehydration process of primary Weddellite crystals via dissolution and recrystallization to Whewellite [2].
• Although not a pathognomonic sign, the presence of a large number of calcium oxalate monohydrate crystals (Whewellite) supports the diagnosis of ethylene glycol poisoning in patients having a metabolic acidosis of unknown aetiology [3].
• Ultrastructure of whewellite kidney stones: electron-analytical investigation [4].
• The essential feature is the deposition of calcium oxalate monohydrate (whewellite) crystals, inducing a foreign body reaction and bone remodelling [5].

High impact information on oxalic acid

• The state of saturation towards whewellite and brushite was directly measured in the 76 urine samples by equilibration with the corresponding salts and was compared to chemical constituents by regression analyses [6].
• This notwithstanding, it is concluded that epitactic catalysis cannot and should not be considered a common mechanism for the formation of whewellite from weddellite (and vice versa) or of kidney stones in general [7].
• On the basis of measurements of adsorption, solution depletion, zeta potential, solubility, seeded-crystal growth, nucleation, and intrarenal precipitation in rats, it was not possible to show that allopurinol retards the crystallization of calcium oxalate (whewellite) [8].
• The possible conversion of Weddellite into Whewellite in vivo is demonstrated by in vitro experiments [9].

Chemical compound and disease context of oxalic acid

• Using such morphoconstitutional studies leads to a classification of urinary stones in seven distinctive types and twenty-one subtypes among monohydrate (whewellite) and dihydrate (weddellite) calcium oxalates, phosphates, uric acid, urates, protein, and cystine calculi [10].

Analytical, diagnostic and therapeutic context of oxalic acid

• In vivo formation of whewellite crystals occurs with massive crystallization only [11].
• Crystal morphologies in whewellite stones: electron microscopy [12].
• Both dried and freshly extracted samples of whewellite stones were examined by light, scanning, and transmission electron microscopy to determine the spatial distribution of the organic (matrix) and inorganic (crystal) phases [12].
• The comparison of the structures of the intrarenally formed crystals with those of Whewellite stones by scanning electron microscopy and the examination of isolated crystals by x-ray diffraction showed the intratubular crystals to consist of Whewellite [13].

References