Disease relevance of PROPETAMPHOS

• Five volunteers ingested a propetamphos dose of 10 micrograms kg-1 (35 nmol kg-1) body weight [1].
• Plunge dipping in diazinon, propetamphos or flumethrin, or the use of synthetic pyrethroid pour-on preparations and an oral drench of ivermectin had little effect because ear mite infestations were detected in the flocks after these treatments [2].
• Propetamphos pour-on formulation for the control of lice on sheep: effect of lice on weight gain and wool production [3].
• The TIE programme indicated that the most likely toxic agents within the effluent were the organophosphate pesticides diazinon and to lesser extent propetamphos, although these did not account for all of the observed toxicity [4].

High impact information on PROPETAMPHOS

• Toxicology and fate of Pestanal and commercial propetamphos formulations in river and estuarine sediment [5].
• Three insecticides were selected for experimental investigation: diazinon, propetamphos (OPs) and cis-permethrin (SP), representative of the active ingredients used in sheep dip formulations, with additional uses in insect control in crops, and for domestic control of flies, mosquitoes, cockroaches, lice, ticks and spiders [6].
• The present paper presents data from a human volunteer study investigating the toxicokinetics of the organophosphorus pesticide propetamphos following oral and dermal exposure [1].
• Biological monitoring of exposure to propetamphos has until recently relied on the measurement of cholinesterase activity in plasma [7].
• The ability to detect and follow the elimination of low doses of propetamphos by measurement of 'total' (after hydrolysis) urinary MEPT suggests it is a suitable biomarker of propetamphos exposure [1].

Biological context of PROPETAMPHOS

• A treated-surface test was used in a bioassay to detect insecticide resistance to the organophosphorus compounds diazinon and propetamphos, in larvae of field strains of Lucilia cuprina in New Zealand during 1990/91 and 1991/92 (December-April) [8].

Associations of PROPETAMPHOS with other chemical compounds

• Survey of levels of propetamphos and diazinon used to control sheep scab in Northern Ireland [9].

Analytical, diagnostic and therapeutic context of PROPETAMPHOS

• Oral and dermal exposure to propetamphos: a human volunteer study [7].
• Meat and fat tissues of chickens slaughtered on the day after treatment contained small amounts of propetamphos (0.003 and 0.02 mg/kg, respectively) [10].
• Blood samples were withdrawn via the cannula at predetermined timepoints to quantitate plasma concentrations of propetamphos over time [11].

References