Disease relevance of Flumethrin

• The effect of tick infestations on liveweight gain (LWG) was assessed by comparison of weight changes in flumethrin-treated N'Dama and Gobra zebu cattle (16-20 months old) with respective control groups submitted to natural tick challenge over 1 year [1].
• Flumethrin was applied at 1 mg active ingredient (a.i.) kg-1 body weight along the backline of cattle [2].
• A clinical trial to evaluate the effects of flumethrin or ivermectin treatment on hemoparasites, gastrointestinal parasites, conception and daily weight gain in a dairy farm in Japan [3].
• METHODS AND RESULTS: Previously isolated SP-degrading Pseudomonas sp. and Serratia sp. were used in cultures containing either flumethrin SP or cypermethrin SP formulations [4].
• Investigation of the efficacy of flumethrin pour-on for the control of high tsetse and trypanosomiasis challenge in Kenya [5].

High impact information on Flumethrin

• Pretreatment with flumethrin decreased the activities of NADPH-cytochrome c reductase (38%), aniline hydroxylase (53%), aminopyrine N-demethylase (54%), and UDP-glucuronosyltransferase (34%), and the content of cytochrome P450 (36%) in hepatic microsomes [6].
• To assess the dynamics of the carrier state, six carriers were identified, treated with flumethrin and sampled once every 3 weeks during 6 months [7].
• Toxicology and metabolism of isomers of flumethrin in larvae of pyrethroid-susceptible and resistant strains of the cattle tick Boophilus microplus (Acari: Ixodidae) [8].
• Deltamethrin and flumethrin pour-on formulations for the control of Ixodes ricinus on cattle [9].
• The efficacy of 2 sets of collars (Kiltix Collar, Bayer AG), containing different plasticisers and impregnated with the acaricides flumethrin (2.25%) and propoxur (10%), was compared against adult Rhipicephalus sanguineus on experimentally infested, kennelled dogs [10].

Biological context of Flumethrin

• Tick control on cattle with flumethrin pour-on through a Duncan Applicator [11].
• Flumethrin caused significant reduction in oviposition and hatchability in female ticks that survived sublethal concentrations, while sublethal doses of coumaphos had no effect on the reproductive potential of the tick [12].
• The genotoxic potential of the pyrethroid flumethrin was evaluated by using the combined protocol of metaphase analysis and micronucleus test in vivo in mouse bone marrow [13].
• Flumethrin showed a cytotoxic effect on both myelopoiesis and erythropoiesis, as evidenced by a reduction in the mitotic index and in polychromatic erythrocyte values [13].

Anatomical context of Flumethrin

• Evaluation of the genotoxic potential of flumethrin in mouse bone marrow by chromosomal analysis and micronucleus test [13].

Associations of Flumethrin with other chemical compounds

• It was characterized by resistance to permethrin, cypermethrin, and flumethrin, synergized by TPP and PBO, but no resistance to DDT [14].

Analytical, diagnostic and therapeutic context of Flumethrin

• Bioassays tested resistant and susceptible larvae along with their hybrid F1 and F2 progeny against a series of concentrations of flumethrin (0, 0.0075, 0.00150, 0.00300, 0.00600 and 0.01200 microg/g) [15].
• Portions of polyethylene strips of flumethrin from treated hives were sampled weekly to determine acaricide persistence using gas chromatography [16].
• The fly-specific effects of Flumethrin Pour-on were time-dependent: Clear effects on the performance of the flies were observed during the first 20 days after treatment of the Zebu; an initial 90% "knock down" effect decreased to 40% during the first 15 days [17].

References