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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Insecticide Resistance

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Disease relevance of Insecticide Resistance

  • In order to examine the conservation of the mechanism of cyclodiene insecticide resistance between species we cloned a cDNA from the yellow fever mosquito Aedes aegypti homologous to the resistance gene Rdl in Drosophila [1].

High impact information on Insecticide Resistance


Biological context of Insecticide Resistance


Anatomical context of Insecticide Resistance

  • Considerable differences in some enzyme activities were found between the strains. pNA demethylation and AP demethylation were substantially higher in all IR strains, while no correlation could be found between their increased insecticide resistance and BP hydroxylating capacity or cytochrome P-450 content of the microsomes [10].

Associations of Insecticide Resistance with chemical compounds


Gene context of Insecticide Resistance


Analytical, diagnostic and therapeutic context of Insecticide Resistance


  1. Cloning and sequencing of the cyclodiene insecticide resistance gene from the yellow fever mosquito Aedes aegypti. Conservation of the gene and resistance associated mutation with Drosophila. Thompson, M., Shotkoski, F., ffrench-Constant, R. FEBS Lett. (1993) [Pubmed]
  2. A point mutation in a Drosophila GABA receptor confers insecticide resistance. Ffrench-Constant, R.H., Rocheleau, T.A., Steichen, J.C., Chalmers, A.E. Nature (1993) [Pubmed]
  3. Insect juvenile hormone resistance gene homology with the bHLH-PAS family of transcriptional regulators. Ashok, M., Turner, C., Wilson, T.G. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  4. Tight genetic linkage between the kdr insecticide resistance trait and a voltage-sensitive sodium channel gene in the house fly. Knipple, D.C., Doyle, K.E., Marsella-Herrick, P.A., Soderlund, D.M. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  5. A single-amino acid substitution in a gamma-aminobutyric acid subtype A receptor locus is associated with cyclodiene insecticide resistance in Drosophila populations. ffrench-Constant, R.H., Steichen, J.C., Rocheleau, T.A., Aronstein, K., Roush, R.T. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  6. maT--a clade of transposons intermediate between mariner and Tc1. Claudianos, C., Brownlie, J., Russell, R., Oakeshott, J., Whyard, S. Mol. Biol. Evol. (2002) [Pubmed]
  7. GABA receptor minigene rescues insecticide resistance phenotypes in Drosophila. Stilwell, G.E., Rocheleau, T., ffrench-Constant, R.H. J. Mol. Biol. (1995) [Pubmed]
  8. Point mutations associated with insecticide resistance in the Drosophila cytochrome P450 Cyp6a2 enable DDT metabolism. Amichot, M., Tarès, S., Brun-Barale, A., Arthaud, L., Bride, J.M., Bergé, J.B. Eur. J. Biochem. (2004) [Pubmed]
  9. Gene expression in insecticide resistant and susceptible Anopheles gambiae strains constitutively or after insecticide exposure. Vontas, J., Blass, C., Koutsos, A.C., David, J.P., Kafatos, F.C., Louis, C., Hemingway, J., Christophides, G.K., Ranson, H. Insect Mol. Biol. (2005) [Pubmed]
  10. Strain-differences and inducibility of microsomal oxidative enzymes in Drosophila melanogaster flies. Zijlstra, J.A., Vogel, E.W., Breimer, D.D. Chem. Biol. Interact. (1984) [Pubmed]
  11. Heterologous expression of four glutathione transferase genes genetically linked to a major insecticide-resistance locus from the malaria vector Anopheles gambiae. Ortelli, F., Rossiter, L.C., Vontas, J., Ranson, H., Hemingway, J. Biochem. J. (2003) [Pubmed]
  12. Influence of permethrin, diazinon and ivermectin treatments on insecticide resistance in the horn fly (Diptera: Muscidae). Byford, R.L., Craig, M.E., DeRouen, S.M., Kimball, M.D., Morrison, D.G., Wyatt, W.E., Foil, L.D. Int. J. Parasitol. (1999) [Pubmed]
  13. Serine proteinase over-expression in relation to deltamethrin resistance in Culex pipiens pallens. Gong, M., Shen, B., Gu, Y., Tian, H., Ma, L., Li, X., Yang, M., Hu, Y., Sun, Y., Hu, X., Li, J., Zhu, C. Arch. Biochem. Biophys. (2005) [Pubmed]
  14. Comparison of esterase gene amplification, gene expression and esterase activity in insecticide susceptible and resistant strains of the brown planthopper, Nilaparvata lugens (Stål). Vontas, J.G., Small, G.J., Hemingway, J. Insect Mol. Biol. (2000) [Pubmed]
  15. Mutations in the house fly Vssc1 sodium channel gene associated with super-kdr resistance abolish the pyrethroid sensitivity of Vssc1/tipE sodium channels expressed in Xenopus oocytes. Lee, S.H., Smith, T.J., Knipple, D.C., Soderlund, D.M. Insect Biochem. Mol. Biol. (1999) [Pubmed]
  16. Three second chromosome-linked clustered Cyp6 genes show differential constitutive and barbital-induced expression in DDT-resistant and susceptible strains of Drosophila melanogaster. Maitra, S., Dombrowski, S.M., Waters, L.C., Ganguly, R. Gene (1996) [Pubmed]
  17. World-wide survey of an Accord insertion and its association with DDT resistance in Drosophila melanogaster. Catania, F., Kauer, M.O., Daborn, P.J., Yen, J.L., Ffrench-Constant, R.H., Schlotterer, C. Mol. Ecol. (2004) [Pubmed]
  18. Microarray analysis of cytochrome P450 mediated insecticide resistance in Drosophila. Le Goff, G., Boundy, S., Daborn, P.J., Yen, J.L., Sofer, L., Lind, R., Sabourault, C., Madi-Ravazzi, L., ffrench-Constant, R.H. Insect Biochem. Mol. Biol. (2003) [Pubmed]
  19. Cytochrome P450 catalysed insecticide metabolism: chemical and theoretical models. Keserü, G.M. Science progress. (1998) [Pubmed]
  20. Molecular cloning and heterologous expression of a glutathione S-transferase involved in insecticide resistance from the diamondback moth, Plutella xylostella. Huang, H.S., Hu, N.T., Yao, Y.E., Wu, C.Y., Chiang, S.W., Sun, C.N. Insect Biochem. Mol. Biol. (1998) [Pubmed]
  21. Evaluation of three methods for detecting permethrin resistance in adult and nymphal Blattella germanica (Dictyoptera: Blattellidae). Ladonni, H. J. Econ. Entomol. (2001) [Pubmed]
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