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Chemical Compound Review

AC1O5PMW     but-2-enedioic acid; (8S,10R,13S,14S,16R...

Synonyms: U-75412E, U75412E, U 75412E, 130590-09-9
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Disease relevance of (8S,10S,13S,14S,16R,17S)-17-[2-[4-(3-ethylamino-2-pyridyl)piperazin-1-yl]acetyl]-10,13,16-trimethyl-6,7,8,12,14,15,16,17-octahydrocyclopenta[a]phenanthren-3-one

  • U75412E prevented progressive burn ischemia and the expansion of tissue loss [1].
  • In a simulated fire-related smoke exposure protocol, New Zealand white rabbits were utilized to investigate the potential effects of the 21-aminosteroid (lazaroid) analog U75412E on the early events of acute lung injury [2].
  • Retinal toxicity of intravitreal lazaroid (21-aminosteroid U75412E) [3].
  • Histopathology indicated that 16 mM U75412E pretreatment attenuated increases in wet lung/body weight ratios, inflammatory focus, and interstitial oedema associated with smoke insult [4].
  • Inhalation of total of 4.6 mg U75412E aerosolized at a rate of 1.53 mg/min for 3 min before or after smoke significantly prevented or limited the extent of alveolar hypoventilation, interstitial edema, and tumor necrosis factor-alpha (TNF-alpha) by pulmonary alveolar macrophages (PAM) ex vivo observed at 2 h [5].

High impact information on (8S,10S,13S,14S,16R,17S)-17-[2-[4-(3-ethylamino-2-pyridyl)piperazin-1-yl]acetyl]-10,13,16-trimethyl-6,7,8,12,14,15,16,17-octahydrocyclopenta[a]phenanthren-3-one


Biological context of (8S,10S,13S,14S,16R,17S)-17-[2-[4-(3-ethylamino-2-pyridyl)piperazin-1-yl]acetyl]-10,13,16-trimethyl-6,7,8,12,14,15,16,17-octahydrocyclopenta[a]phenanthren-3-one


Anatomical context of (8S,10S,13S,14S,16R,17S)-17-[2-[4-(3-ethylamino-2-pyridyl)piperazin-1-yl]acetyl]-10,13,16-trimethyl-6,7,8,12,14,15,16,17-octahydrocyclopenta[a]phenanthren-3-one

  • In this study, 21-aminosteroid U75412E was injected into the vitreous body of rabbit eyes to evaluate its suitability for intraocular injection and its toxicity on intraocular tissues [3].
  • In this paper, we show that a novel antioxidant (lazaroid U75412E, a free radical scavenger) suppressed mitogen-induced T cell proliferation in vitro [10].

Associations of (8S,10S,13S,14S,16R,17S)-17-[2-[4-(3-ethylamino-2-pyridyl)piperazin-1-yl]acetyl]-10,13,16-trimethyl-6,7,8,12,14,15,16,17-octahydrocyclopenta[a]phenanthren-3-one with other chemical compounds


  1. U75412E, a lazaroid, prevents progressive burn ischemia in a rat burn model. Choi, M., Ehrlich, H.P. Am. J. Pathol. (1993) [Pubmed]
  2. Early alterations of lung injury following acute smoke exposure and 21-aminosteroid treatment. Wang, S., Lantz, R.C., Robledo, R.F., Breceda, V., Hays, A.M., Witten, M.L. Toxicologic pathology. (1999) [Pubmed]
  3. Retinal toxicity of intravitreal lazaroid (21-aminosteroid U75412E). Cruz, S.A., Karaçorlu, M., Peyman, G.A. International ophthalmology. (1992) [Pubmed]
  4. The prophylactic effects of U75412E pretreatment in a smoke-induced lung injury rabbit model. Wang, S., Lantz, R.C., Chen, G.J., Breceda, V., Rider, E., Hays, A.M., Parliman, G., Tollinger, B.J., Robledo, R.F., Kunke, K., Tinajero, J., Witten, M.L. Pharmacol. Toxicol. (1996) [Pubmed]
  5. A free radical scavenger (Lazaroid U75412E) attenuates tumor necrosis factor-alpha generation in a rabbit model of smoke-induced lung injury. Wang, S., Lantz, R.C., Rider, E.D., Chen, G.J., Breceda, V., Hays, A.M., Robledo, R.F., Tollinger, B.J., Dinesh, S.V., Witten, M.L. Respiration; international review of thoracic diseases. (1997) [Pubmed]
  6. Antioxidant activity of lazaroid (U-75412E) and its protective effects against crystalline silica-induced cytotoxicity. Huang, S.H., Leonard, S., Shi, X., Goins, M.R., Vallyathan, V. Free Radic. Biol. Med. (1998) [Pubmed]
  7. Effects of 21-aminosteroids in neonatal rat cardiac myocyte cell cultures exposed to free radicals. Burton, K.P. Cardiovasc. Res. (1994) [Pubmed]
  8. Cytotoxicity of lazaroid U-75412E in human epithelial cell line (Wish). Mattana, A., Bennardini, F., Juliano, C., Picci, V., Marceddu, S., Sciola, L., Pippia, P., Franconi, F. Biochem. Pharmacol. (1994) [Pubmed]
  9. Modulation of microvascular permeability by 21-aminosteroids after burn injuries. Dyess, D.L., Collins, J.N., Ardell, J.L., Townsley, M.I., Taylor, A.E., Ferrara, J.J. The Journal of burn care & rehabilitation. (2000) [Pubmed]
  10. Suppressive effects of a novel antioxidant compound on human T cell functions in vitro. Kalsi, J.K., Clay, K., Rickard, D., Hall, N.D. Agents Actions (1993) [Pubmed]
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