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Chemical Compound Review

AC1LD8XR     [(3S)-3-[6-[[(2S)-2-[[(2S)-2- acetamido-6...

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High impact information on 125I]iodo-

  • All three forms of hGH had a similar ability to inhibit [125I]iodo-met-hGH 22K binding to 3T3-adipocytes [1].
  • Visualization of [125I]iodo-alpha hANP-specific binding sites in APA and adjacent normal adrenal tissues by an in vitro receptor autoradiographic technique showed that these sites were localized only in normal adrenal tissue, but not in APA tissue [2].
  • Specific binding of [125I]iodo human GH [( 125I]iodo hGH) was rapid, reversible, and time and temperature dependent [3].
  • The partially purified activity competes with [125I]iodo-platelet-derived growth factor (PDGF) for binding to target cells, and the biological activity is neutralized with anti-PDGF IgG, suggesting shared domains in the two molecules [4].
  • 2. Denervation by sciatic nerve section increased the number of [125I]iodo-alpha-bungarotoxin ([125I]BTX) binding sites from low, unmeasurable levels to 39 +/- 3 fmol of toxin bound per milligram muscle protein at 21 days [5].

Biological context of 125I]iodo-

  • As part of a study concerning the mechanism of mammotroph autoregulation, the intracellular fate of [125I]iodo rat PRL, internalized by mammotrophs, was determined by quantitative electron microscope autoradiography [6].

Anatomical context of 125I]iodo-

  • However, freeze-thawing of the cells fragmented the membranes, releasing [125I]iodo TSH binding as well as LATS/TSI absorbing activities into the soluble (cell sap) fraction [7].
  • The granulosa cells degrade rat [125I]iodo high density lipoprotein (HDL) to acid-soluble products, mainly monoiodotyrosine [8].
  • An enzyme hydrolysing [125I]iodo-insulin B chain was enriched in preparations of intestinal microvilli [9].
  • Membranes purified from thyroid homogenates or isolated thyroid cells absorbed LATS/TSI activities and specifically bound [125I]iodo TSH [7].
  • Time- and temperature-dependent specific binding of [125I]iodo-insulin to kidney cell membranes was demonstrated [10].

Associations of 125I]iodo- with other chemical compounds


Gene context of 125I]iodo-

  • Purified thyroglobulin, nuclei, mitochondria and ribosomes did not bind [125I]iodo TSH nor did they absorb LATS/TSI activities [7].
  • That this regulation was partly produced by uptake of secreted PRL from the medium was demonstrated by supplementing the medium with [125I]iodo-rat PRL [13].
  • Concomitant treatment with FSH and T4 (10(-7) M) markedly increased FSH-stimulated induction of [125I]iodo-human CG binding to cultured granulosa cells obtained from small follicles [14].
  • Whereas native hCG displayed negligible binding potency when compared with that of ovine FSH in competition with [125I]iodo-human FSH for ovarian receptors, AHF-hCG bound to FSH receptors with about 5% of the binding affinity of ovine FSH [15].
  • The beta-subunits of hFSH, hTSH and hLH did not inhibit binding of [125I]iodo-beta hCG to the antibody at up to 250 ng/tube [16].

Analytical, diagnostic and therapeutic context of 125I]iodo-


  1. Pituitary and recombinant deoxyribonucleic acid-derived human growth hormones alter glucose metabolism in 3T3 adipocytes. Schwartz, J., Foster, C.M. J. Clin. Endocrinol. Metab. (1986) [Pubmed]
  2. Lack of inhibitory effect of alpha-human atrial natriuretic polypeptide on aldosteronogenesis in aldosterone-producing adenoma. Higuchi, K., Nawata, H., Kato, K., Ibayashi, H., Matsuo, H. J. Clin. Endocrinol. Metab. (1986) [Pubmed]
  3. Identification and characterization of specific growth hormone receptors in cultured human fibroblasts. Murphy, L.J., Vrhovsek, E., Lazarus, L. J. Clin. Endocrinol. Metab. (1983) [Pubmed]
  4. Differentiation-dependent production of a platelet-derived growth factor-like mitoattractant by endoderm cells derived from embryonal carcinoma cells. Grotendorst, G.R., Harvey, A.K., Nagarajan, L., Anderson, W.B., Gatewood, E. J. Cell. Physiol. (1988) [Pubmed]
  5. Acetylcholine receptors and sodium channels in denervated and botulinum-toxin-treated adult rat muscle. Bambrick, L., Gordon, T. J. Physiol. (Lond.) (1987) [Pubmed]
  6. Mammotroph autoregulation: intracellular fate of internalized prolactin. Giss, B.J., Walker, A.M. Mol. Cell. Endocrinol. (1985) [Pubmed]
  7. Thyrotropin binding and long acting thyroid stimulator absorbing activities in subcellular fractions from isolated thyroid cells and thyroid homogenates. Mehdi, S.Q., Badger, J., Kriss, J.P. Endocrinology (1977) [Pubmed]
  8. Degradation of rat and human lipoproteins by cultured rat ovary granulosa cells. Schreiber, J.R., Nakamura, K., Weinstein, D.B. Endocrinology (1982) [Pubmed]
  9. A neutral endopeptidase in the microvillar membrane of pig intestine. Partial purification and properties. Danielsen, E.M., Vyas, J.P., Kenny, A.J. Biochem. J. (1980) [Pubmed]
  10. Insulin and glucagon binding and degradation by kidney cell membranes. Duckworth, W.C. Endocrinology (1978) [Pubmed]
  11. Vasoactive intestinal peptide: a novel stimulator of steroidogenesis by cultured rat granulosa cells. Davoren, J.B., Hsueh, A.J. Biol. Reprod. (1985) [Pubmed]
  12. Divergent effects of cations on follicle-stimulating hormone- and forskolin-activated adenylyl cyclase in granulosa cells. Ford, K.A., Hunzicker-Dunn, M., LaBarbera, A.R. Biol. Reprod. (1987) [Pubmed]
  13. Mammotroph autoregulation: uptake of secreted prolactin and inhibition of secretion. Kadowaki, J., Ku, N., Oetting, W.S., Walker, A.M. Endocrinology (1984) [Pubmed]
  14. The role of thyroid hormone as a biological amplifier of the actions of follicle-stimulating hormone in the functional differentiation of cultured porcine granulosa cells. Maruo, T., Hayashi, M., Matsuo, H., Yamamoto, T., Okada, H., Mochizuki, M. Endocrinology (1987) [Pubmed]
  15. Enhanced follicle-stimulating hormone activity of deglycosylated human chorionic gonadotropin in ovarian granulosa cells. Ranta, T., Chen, H.C., Shimohigashi, Y., Baukal, A.J., Knecht, M., Catt, K.J. Endocrinology (1985) [Pubmed]
  16. Development and characterization of a monoclonal antibody which distinguishes the beta-subunit of human chorionic gonadotropin (beta hCG) in the presence of the hCG. Khazaeli, M.B., England, B.G., Dieterle, R.C., Nordblom, G.D., Kabza, G.A., Beierwaltes, W.H. Endocrinology (1981) [Pubmed]
  17. Placental protein 12 is a decidual protein that binds somatomedin and has an identical N-terminal amino acid sequence with somatomedin-binding protein from human amniotic fluid. Koistinen, R., Kalkkinen, N., Huhtala, M.L., Seppälä, M., Bohn, H., Rutanen, E.M. Endocrinology (1986) [Pubmed]
  18. Specific receptor and cardiovascular effects of calcitonin gene-related peptide. Sigrist, S., Franco-Cereceda, A., Muff, R., Henke, H., Lundberg, J.M., Fischer, J.A. Endocrinology (1986) [Pubmed]
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