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Chemical Compound Review

Dermolastin     (E)-N-ethyl-6,6-dimethyl-N- [[3-[(4...

Synonyms: CHEMBL27885, NB-598, CS-1274, CHEBI:136374, NB598, ...
 
 
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High impact information on NB 598

 

Biological context of NB 598

 

Anatomical context of NB 598

 

Associations of NB 598 with other chemical compounds

 

Gene context of NB 598

 

Analytical, diagnostic and therapeutic context of NB 598

  • Furthermore, multiple oral administration of NB-598 decreased serum cholesterol levels in dogs (Horie, M., Tsuchiya, Y., Hayashi, M., Iida, Y., Iwasawa, Y., Nagata, Y., Sawasaki, Y., Fukuzumi, H., Kitani, K., and Kamei, T. (1990) J. Biol. Chem. 265, 18075-18078) [5].

References

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  2. Dual roles for cholesterol in mammalian cells. Xu, F., Rychnovsky, S.D., Belani, J.D., Hobbs, H.H., Cohen, J.C., Rawson, R.B. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  3. Transcriptional regulation of squalene epoxidase by sterols and inhibitors in HeLa cells. Nakamura, Y., Sakakibara, J., Izumi, T., Shibata, A., Ono, T. J. Biol. Chem. (1996) [Pubmed]
  4. Mevalonic acid-dependent degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase in vivo and in vitro. Correll, C.C., Edwards, P.A. J. Biol. Chem. (1994) [Pubmed]
  5. Effect of a novel squalene epoxidase inhibitor, NB-598, on the regulation of cholesterol metabolism in Hep G2 cells. Hidaka, Y., Hotta, H., Nagata, Y., Iwasawa, Y., Horie, M., Kamei, T. J. Biol. Chem. (1991) [Pubmed]
  6. Effect of an inhibitor of squalene epoxidase, NB-598, on lipid metabolism in Hep G2 cells. Nagata, Y., Horie, M., Hidaka, Y., Yonemoto, M., Hayashi, M., Watanabe, H., Ishida, F., Kamei, T. Chem. Pharm. Bull. (1992) [Pubmed]
  7. Effects of NB-598, a potent squalene epoxidase inhibitor, on the apical membrane uptake of cholesterol and basolateral membrane secretion of lipids in Caco-2 cells. Horie, M., Iwasawa, Y., Satoh, T., Shimizu, A., Nagata, Y., Kamei, T. Biochem. Pharmacol. (1993) [Pubmed]
  8. Molecular cloning and expression of rat squalene epoxidase. Sakakibara, J., Watanabe, R., Kanai, Y., Ono, T. J. Biol. Chem. (1995) [Pubmed]
  9. Squalene synthase inhibitors suppress triglyceride biosynthesis through the farnesol pathway in rat hepatocytes. Hiyoshi, H., Yanagimachi, M., Ito, M., Yasuda, N., Okada, T., Ikuta, H., Shinmyo, D., Tanaka, K., Kurusu, N., Yoshida, I., Abe, S., Saeki, T., Tanaka, H. J. Lipid Res. (2003) [Pubmed]
  10. Purification and characterization of recombinant squalene epoxidase. Nagumo, A., Kamei, T., Sakakibara, J., Ono, T. J. Lipid Res. (1995) [Pubmed]
  11. Enzymatic properties of squalene epoxidase from Saccharomyces cerevisiae. Satoh, T., Horie, M., Watanabe, H., Tsuchiya, Y., Kamei, T. Biol. Pharm. Bull. (1993) [Pubmed]
  12. NB-598: a potent competitive inhibitor of squalene epoxidase. Horie, M., Tsuchiya, Y., Hayashi, M., Iida, Y., Iwasawa, Y., Nagata, Y., Sawasaki, Y., Fukuzumi, H., Kitani, K., Kamei, T. J. Biol. Chem. (1990) [Pubmed]
 
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