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Gene Review

Sqle  -  squalene epoxidase

Rattus norvegicus

Synonyms: Erg1, SE, Squalene epoxidase, Squalene monooxygenase
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Disease relevance of Sqle


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Biological context of Sqle


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Analytical, diagnostic and therapeutic context of Sqle


  1. Molecular cloning and expression of rat squalene epoxidase. Sakakibara, J., Watanabe, R., Kanai, Y., Ono, T. J. Biol. Chem. (1995) [Pubmed]
  2. Inhibition of cholesterol biosynthesis by squalene epoxidase inhibitor avoids apoptotic cell death in L6 myoblasts. Matzno, S., Yamauchi, T., Gohda, M., Ishida, N., Katsuura, K., Hanasaki, Y., Tokunaga, T., Itoh, H., Nakamura, N. J. Lipid Res. (1997) [Pubmed]
  3. In vivo requirement of protein prenylation for maintenance of retinal cytoarchitecture and photoreceptor structure. Pittler, S.J., Fliesler, S.J., Fisher, P.L., Keller, P.K., Rapp, L.M. J. Cell Biol. (1995) [Pubmed]
  4. Phosphorylation of supernatant protein factor enhances its ability to stimulate microsomal squalene monooxygenase. Singh, D.K., Mokashi, V., Elmore, C.L., Porter, T.D. J. Biol. Chem. (2003) [Pubmed]
  5. Tellurite specifically affects squalene epoxidase: investigations examining the mechanism of tellurium-induced neuropathy. Wagner, M., Toews, A.D., Morell, P. J. Neurochem. (1995) [Pubmed]
  6. Cholesterol-dependent modulation of dendrite outgrowth and microtubule stability in cultured neurons. Fan, Q.W., Yu, W., Gong, J.S., Zou, K., Sawamura, N., Senda, T., Yanagisawa, K., Michikawa, M. J. Neurochem. (2002) [Pubmed]
  7. Green tea polyphenols: novel and potent inhibitors of squalene epoxidase. Abe, I., Seki, T., Umehara, K., Miyase, T., Noguchi, H., Sakakibara, J., Ono, T. Biochem. Biophys. Res. Commun. (2000) [Pubmed]
  8. Supernatant protein factor facilitates intermembrane transfer of squalene. Friedlander, E.J., Caras, I.W., Lin, L.F., Bloch, K. J. Biol. Chem. (1980) [Pubmed]
  9. Regulation of squalene epoxidase activity and comparison of catalytic properties of rat liver and Chinese hamster ovary cell-derived enzymes. Eilenberg, H., Shechter, I. J. Lipid Res. (1987) [Pubmed]
  10. Formation of intranuclear crystalloids and proliferation of the smooth endoplasmic reticulum in schwann cells induced by tellurium treatment: association with overexpression of HMG CoA reductase and HMG CoA synthase mRNA. Berciano, M.T., Fernandez, R., Pena, E., Calle, E., Villagra, N.T., Rodriguez-Rey, J.C., Lafarga, M. Glia (2000) [Pubmed]
  11. Tellurium blocks cholesterol synthesis by inhibiting squalene metabolism: preferential vulnerability to this metabolic block leads to peripheral nervous system demyelination. Wagner-Recio, M., Toews, A.D., Morell, P. J. Neurochem. (1991) [Pubmed]
  12. Tellurium-induced alterations in 3-hydroxy-3-methylglutaryl-CoA reductase gene expression and enzyme activity: differential effects in sciatic nerve and liver suggest tissue-specific regulation of cholesterol synthesis. Toews, A.D., Goodrum, J.F., Lee, S.Y., Eckermann, C., Morell, P. J. Neurochem. (1991) [Pubmed]
  13. Protein-facilitated intermembrane transfer of squalene. Demonstration by density gradient centrifugation. Kojima, Y., Friedlander, E.J., Bloch, K. J. Biol. Chem. (1981) [Pubmed]
  14. Solubilization and partial characterization of rat liver squalene epoxidase. Ono, T., Bloch, K. J. Biol. Chem. (1975) [Pubmed]
  15. Effects of a supernatant protein activator on microsomal squalene-2,3-oxide-lanosterol cyclase. Caras, I.W., Bloch, K. J. Biol. Chem. (1979) [Pubmed]
  16. Role of organotellurium species in tellurium neuropathy. Goodrum, J.F. Neurochem. Res. (1998) [Pubmed]
  17. Mevalonic acid-dependent degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase in vivo and in vitro. Correll, C.C., Edwards, P.A. J. Biol. Chem. (1994) [Pubmed]
  18. Regulation of rat liver microsomal squalene epoxidase: inactivation of the supernatant protein factor by nucleotides. Senjo, M., Ishibashi, T., Imai, Y. Arch. Biochem. Biophys. (1985) [Pubmed]
  19. Purification and partial characterization of squalene epoxidase from rat liver microsomes. Ono, T., Nakazono, K., Kosaka, H. Biochim. Biophys. Acta (1982) [Pubmed]
  20. Differential accumulation of mRNA for immediate early genes and heat shock genes in heart after ischaemic injury. Plumier, J.C., Robertson, H.A., Currie, R.W. J. Mol. Cell. Cardiol. (1996) [Pubmed]
  21. Photoaffinity labeling and site-directed mutagenesis of rat squalene epoxidase. Lee, H.K., Denner-Ancona, P., Sakakibara, J., Ono, T., Prestwich, G.D. Arch. Biochem. Biophys. (2000) [Pubmed]
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