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Chemical Compound Review

Genetron 133a     2-chloro-1,1,1-trifluoro- ethane

Synonyms: CCRIS 154, HCFC-133a, Forane 133a, CHEMBL142556, Freon 133a, ...
 
 
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Disease relevance of Chlorotrifluoroethane

  • One patient developed viral hepatitis A during the course of anaesthetic administration; this patient was the only one whose serum bromide concentrations fell substantially and whose exhaled CTF concentration increased as more anaesthetics were administered [1].
 

High impact information on Chlorotrifluoroethane

 

Anatomical context of Chlorotrifluoroethane

  • Detection limits for CDE and CTE were 2 pmole/ml in blood and 10 pmole/g in liver and the mean relative standard deviations are no greater than +/- 6% except for CTE in hepatic microsomes (+/- 9%) [7].
 

Associations of Chlorotrifluoroethane with other chemical compounds

References

  1. Metabolism of halothane in children having repeated halothane anaesthetics. Plummer, J.L., Steven, I.M., Cousins, M.J. Anaesthesia and intensive care. (1987) [Pubmed]
  2. Halothane-dependent lipid peroxidation in human liver microsomes is catalyzed by cytochrome P4502A6 (CYP2A6). Minoda, Y., Kharasch, E.D. Anesthesiology (2001) [Pubmed]
  3. Reductive metabolism of halothane by purified cytochrome P-450. Van Dyke, R.A., Baker, M.T., Jansson, I., Schenkman, J. Biochem. Pharmacol. (1988) [Pubmed]
  4. Guinea-pig model of halothane-associated hepatotoxicity in the absence of enzyme induction and hypoxia. Lunam, C.A., Cousins, M.J., Hall, P.D. J. Pharmacol. Exp. Ther. (1985) [Pubmed]
  5. Genetic differences in reductive metabolism and hepatotoxicity of halothane in three rat strains. Gourlay, G.K., Adams, J.F., Cousins, M.J., Hall, P. Anesthesiology (1981) [Pubmed]
  6. Human reductive halothane metabolism in vitro is catalyzed by cytochrome P450 2A6 and 3A4. Spracklin, D.K., Thummel, K.E., Kharasch, E.D. Drug Metab. Dispos. (1996) [Pubmed]
  7. Quantitative analysis of volatile halothane metabolites in biological tissues by gas chromatography. Maiorino, R.M., Sipes, I.G., Gandolfi, A.J., Brown, B.R. J. Chromatogr. (1979) [Pubmed]
  8. Isoflurane increases the anaerobic metabolites of halothane. Rahman, M., Fujii, K., Sato, N., Yuge, O. Journal of applied toxicology : JAT. (1994) [Pubmed]
  9. Fatality due to recreational use of chlorodifluoromethane and chloropentafluoroethane. Fitzgerald, R.L., Fishel, C.E., Bush, L.L. J. Forensic Sci. (1993) [Pubmed]
  10. Inhibitory effects of corticoids on reductive halothane dehalogenation. Fujii, K. Drug metabolism and drug interactions. (1995) [Pubmed]
 
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