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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

Tenilsetam     3-thiophen-2-ylpiperazin-2-one

Synonyms: Tenilsetamum, CAS-997, SureCN194668, AG-H-49689, CHEMBL2104853, ...
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Disease relevance of CAS 997


Psychiatry related information on CAS 997

  • These experimental data, and clinical studies, reporting a marked improvement in cognition and memory in Alzheimer's disease patients after Tenilsetam treatment, suggest that AGEs might play an important role in the etiology or progression of the disease [4].

High impact information on CAS 997


Biological context of CAS 997

  • The cognition-enhancing drug tenilsetam is an inhibitor of protein crosslinking by advanced glycosylation [5].
  • According to the mechanism proposed, Tenilsetam acts via covalent attachment to glycated proteins, thus blocking the reactive sites for further polymerisation reactions [5].

Anatomical context of CAS 997


Associations of CAS 997 with other chemical compounds


Gene context of CAS 997

  • At weekly intervals, the subjects received randomized single oral doses of placebo, 150 mg, 300 mg and 900 mg tenilsetam (TEN) and 5 mg co-dergocrine-mesylate (CDM) as reference drug [7].

Analytical, diagnostic and therapeutic context of CAS 997


  1. Tenilsetam prevents early diabetic retinopathy without correcting pericyte loss. Hoffmann, J., Alt, A., Lin, J., Lochnit, G., Schubert, U., Schleicher, E., Chavakis, T., Brownlee, M., Van der Woude, F.J., Preissner, K.T., Hammes, H.P. Thromb. Haemost. (2006) [Pubmed]
  2. Free radicals in Alzheimer's dementia: currently available therapeutic strategies. Rösler, M., Retz, W., Thome, J., Riederer, P. J. Neural Transm. Suppl. (1998) [Pubmed]
  3. The carbonyl scavengers aminoguanidine and tenilsetam protect against the neurotoxic effects of methylglyoxal. Webster, J., Urban, C., Berbaum, K., Loske, C., Alpar, A., Gärtner, U., de Arriba, S.G., Arendt, T., Münch, G. Neurotoxicity research. (2005) [Pubmed]
  4. Influence of advanced glycation end-products and AGE-inhibitors on nucleation-dependent polymerization of beta-amyloid peptide. Münch, G., Mayer, S., Michaelis, J., Hipkiss, A.R., Riederer, P., Müller, R., Neumann, A., Schinzel, R., Cunningham, A.M. Biochim. Biophys. Acta (1997) [Pubmed]
  5. The cognition-enhancing drug tenilsetam is an inhibitor of protein crosslinking by advanced glycosylation. Münch, G., Taneli, Y., Schraven, E., Schindler, U., Schinzel, R., Palm, D., Riederer, P. Journal of neural transmission. Parkinson's disease and dementia section. (1994) [Pubmed]
  6. The Maillard reaction inhibitors and their biological and therapeutic significance. Sztanke, K., Pasternak, K. Annales Universitatis Mariae Curie-Skłodowska. Sectio D: Medicina. (2003) [Pubmed]
  7. Psychophysiological research in psychiatry and neuropsychopharmacology. II. The investigation of antihypoxidotic/nootropic drugs (tenilsetam and co-dergocrine-mesylate) in elderlies with the Viennese Psychophysiological Test-System (VPTS). Saletu, B., Semlitsch, H.V., Anderer, P., Resch, F., Presslich, O., Schuster, P. Methods and findings in experimental and clinical pharmacology. (1989) [Pubmed]
  8. Determination of tenilsetam in human plasma and urine by high-performance liquid chromatography. Burrows, J.L., Coppin, F.G. J. Chromatogr. (1990) [Pubmed]
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