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Chemical Compound Review

MJ 1999     N-[4-[1-hydroxy-2-(propan-2...

Synonyms: Betapace, Sotacor, Sotalex, Berlex, Sorine, ...
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Disease relevance of sotalol


High impact information on sotalol

  • METHODS: We administered a radioactive bone-seeking compound (Samarium-Lexidronam, Quadramet, Berlex Laboratories, Wayne, NJ) together with transient T-cell costimulatory blockade to recipient mice [6].
  • BACKGROUND: The administration of alemtuzumab (Campath-1H [C1H]; Berlex Laboratories, Montville, NJ) at transplantation prevents a vigorous immune response and is believed to allow a gradual engagement of the host immune system [7].
  • Ninety patients underwent simultaneous determinations of GFR using 1 mCi of Tc-DTPA and 0.05 mmol/kg Gd-DTPA (Berlex Labs) IV [8].
  • Although studies have been published that examine the biologic activities of the two structurally different forms of recombinant IFN-beta, IFN-beta1a (Rebif), Serono, Geneva, Switzerland) and IFN-beta1b (Betaseron)/Betaferon), Berlex [Montville, NJ]/Schering [Berlin, Germany]), there have been few direct comparative studies [9].
  • Sponsored by the nonprofit Berlex Foundation, this 6-day Faculty Development Course introduces small groups of new faculty to research design, critical appraisal of the literature, scientific writing, and evidence-based medicine [10].

Biological context of sotalol

  • The six- to 12-hour AUC for the Bolar tablets was 24% less than that for Berlex tablets [11].

Associations of sotalol with other chemical compounds

  • METHODS AND RESULTS: We reviewed the number of new, refill, and total prescriptions of all antiarrhythmic agents in the United States from April 2000-December 2001 to assess use of dofetilide and Betapace AF in the drug market [3].
  • Gadopentetate dimeglumine, 0.5 mol/l (Berlex Laboratories, Wayne, NJ, U.S.A.), a LightSpeed QX/i CT (General Electric Medical Systems, Milwaukee, WI, U.S.A.), and an Ultra Sparc II (SUN Microsystems, Santa Clara, CA, U.S.A.) running Advantage Windows 3.1 (General Electric Medical Systems) were used [12].
  • High-resolution MRI with intravenous gadolinium-DTPA (Magnevist, Berlex) has been particularly useful in evaluating patients with a history of prior disk surgery and patients who were not relieved of pain by lumbar diskectomy [13].
  • The patients underwent captopril-enhanced scintigraphy or routine unenhanced US (the usual diagnostic methods at the centres where the study was conducted) and contrast-enhanced US (with Levovist, Berlex Canada, Lachine, Que.). The patients were followed for 3 months after the diagnostic tests were performed [14].

Gene context of sotalol

  • Berlex and its parent company, Schering AG, are developing BX-471 (also known as ZK-811752), the lead in a series of non-peptide chemokine receptor 1 (CCR1) antagonists, for the potential treatment of autoimmune diseases, in particular multiple sclerosis (MS) [291682], [376290], [411184] [15].
  • Positive results from these trials have been reported and Berlex was planning phase II trials in MS patients as of mid-March 2002 [444906] [15].

Analytical, diagnostic and therapeutic context of sotalol


  1. Hemolytic anemia after fludarabine therapy for chronic lymphocytic leukemia. Weiss, R.B., Freiman, J., Kweder, S.L., Diehl, L.F., Byrd, J.C. J. Clin. Oncol. (1998) [Pubmed]
  2. Advances in specific therapy for multiple sclerosis. Jacobs, L., Goodkin, D.E., Rudick, R.A., Herndon, R. Curr. Opin. Neurol. (1994) [Pubmed]
  3. New antiarrhythmic agents for atrial fibrillation and atrial flutter: United States drug market response as an indicator of acceptance. LaPointe, N.M., Pamer, C.A., Kramer, J.M. Pharmacotherapy (2003) [Pubmed]
  4. Systemic recombinant human interferon-beta treatment of relapsing-remitting multiple sclerosis: pilot study analysis and six-year follow-up. Knobler, R.L., Greenstein, J.I., Johnson, K.P., Lublin, F.D., Panitch, H.S., Conway, K., Grant-Gorsen, S.V., Muldoon, J., Marcus, S.G., Wallenberg, J.C. J. Interferon Res. (1993) [Pubmed]
  5. Evaluation of the dofetilide risk-management program. Allen LaPointe, N.M., Chen, A., Hammill, B., DeLong, E., Kramer, J.M., Califf, R.M. Am. Heart J. (2003) [Pubmed]
  6. Targeted bone marrow radioablation with 153Samarium-lexidronam promotes allogeneic hematopoietic chimerism and donor-specific immunologic hyporesponsiveness. Inverardi, L., Linetsky, E., Pileggi, A., Molano, R.D., Serafini, A., Paganelli, G., Ricordi, C. Transplantation (2004) [Pubmed]
  7. Preliminary experience with alemtuzumab (Campath-1H) and low-dose tacrolimus immunosuppression in adult liver transplantation. Tzakis, A.G., Tryphonopoulos, P., Kato, T., Nishida, S., Levi, D.M., Madariaga, J.R., Gaynor, J.J., De Faria, W., Regev, A., Esquenazi, V., Weppler, D., Ruiz, P., Miller, J. Transplantation (2004) [Pubmed]
  8. Hydrated clearance of gadolinium-DTPA as a measurement of glomerular filtration rate. Choyke, P.L., Austin, H.A., Frank, J.A., Girton, M.E., Diggs, R.L., Dwyer, A.J., Miller, L., Nussenblatt, R., McFarland, H., Simon, T. Kidney Int. (1992) [Pubmed]
  9. A comparison of the biologic activity of two recombinant IFN-beta preparations used in the treatment of relapsing-remitting multiple sclerosis. Antonetti, F., Finocchiaro, O., Mascia, M., Terlizzese, M.G., Jaber, A. J. Interferon Cytokine Res. (2002) [Pubmed]
  10. A faculty development course in obstetrics and gynecology. Grimes, D.A., Schulz, K.F., Droegemueller, W., Munsick, R.A., Lisanti, S. Am. J. Obstet. Gynecol. (2000) [Pubmed]
  11. Bioavailability of two manufacturers' sustained-release quinidine gluconate tablets at steady state. Zinny, M.A., Taggart, W.V. Clinical therapeutics. (1984) [Pubmed]
  12. Gadopentetate dimeglumine is potentially an alternative contrast agent for three-dimensional computed tomography angiography with multidetector-row helical scanning. Gupta, A.K., Alberico, R.A., Litwin, A., Kanter, P., Grossman, Z.D. Journal of computer assisted tomography. (2002) [Pubmed]
  13. Preoperative and postoperative neuroradiologic evaluation of lumbar disk herniation. Tash, R., Strauss, R.C., Savitz, M.H. Mt. Sinai J. Med. (1991) [Pubmed]
  14. Impact of Levovist ultrasonographic contrast agent on the diagnosis and management of hypertensive patients with suspected renal artery stenosis: a Canadian multicentre pilot study. Lacourcière, Y., Lévesque, J., Onrot, J.M., Wilson, S.R., Szaky, E., Thibodeau, M., Vasilevsky, M.L., Dashefsky, S.M., Allan, D.R., Lafortune, M., Vendeville, B., Zaleski, W.M., Pagé, D.E., D'Onofrio, F. Canadian Association of Radiologists journal = Journal l'Association canadienne des radiologistes. (2002) [Pubmed]
  15. BX-471 Berlex. Elices, M.J. Current opinion in investigational drugs (London, England : 2000) (2002) [Pubmed]
  16. Alemtuzumab (Campath-1H) combined with tacrolimus in intestinal and multivisceral transplantation. Tzakis, A.G., Kato, T., Nishida, S., Levi, D.M., Tryphonopoulos, P., Madariaga, J.R., De Faria, W., Nery, J.R., Regev, A., Vianna, R., Miller, J., Esquenazi, V., Weppler, D., Ruiz, P. Transplantation (2003) [Pubmed]
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