Disease relevance of Evidence-Based Medicine

• SUMMARY: Studies using level 1 or 2 evidence-based medicine must be conducted to enable better decision making, such as in the application of intratympanic gentamycin or micropressure Meniett therapy at an earlier stage of Meniere's disease [1].
• The apparent contradictions between conclusions from experience-based medicine and evidence-based medicine regarding the efficacy of varicocele treatment and tamoxifen treatment can be explained by scientific reasons [2].
• Risedronate is a first-choice therapy option in the German Guidelines of the Dachverband Osteologie for Osteoporosis according to evidence-based medicine criteria for the treatment of postmenopausal osteoporosis, osteoporosis of the elderly (women aged > 75 years) and glucocorticoid-induced osteoporosis [3].
• According to the rules of evidence-based medicine, the low dose ACTH test should replace the conventional 250 microg test when evaluating for central adrenal insufficiency [4].
• To test participant applications of evidence-based medicine in health plan medical management strategy, 3 conditions were used for illustrative purpose: managing rheumatoid arthritis, increasing remission in depression, and reducing heart disease among diabetics [5].

High impact information on Evidence-Based Medicine

• Guidelines for monitoring of methotrexate therapy: "evidence-based medicine" outside of clinical trials [6].
• Failure to practice evidence-based medicine: why do physicians not treat patients with heart failure with angiotensin-converting enzyme inhibitors [7]?
• CONCLUSIONS: These findings indicate inconsistency in practicing evidence-based medicine in neonatal practice, where therapies are often administered on the basis of weaker evidence of safety and benefit than supports vitamin A supplementation [8].
• CONCLUSION: From the point of view of evidence based medicine it should be seriously questioned whether yttrium synovectomy deserves a place in clinical practice [9].
• Evidence-based medicine provides a means of assessing benefit and risk in the context of the number of patients one needs to treat to obtain benefit (NNT) compared with the number needed to treat for an adverse outcome (NNH) [10].

Chemical compound and disease context of Evidence-Based Medicine

• So given the financial constraints facing healthcare organizations, as well as pressure from such august organizations like the Institute of Medicine to implement evidence-based medicine, flexibility in decision-making may ultimately become the exception rather than the rule [11].

Biological context of Evidence-Based Medicine

• Guided by the principles of evidence-based medicine as outlined by the American Academy of Neurology and the American Academy of Pediatrics, this article reviews the application of antiepileptic drugs for epilepsy and behavioral and psychiatric disorders in children [12].
• Towards evidence-based practice of allergy and clinical immunology: applying an evidence-based medicine approach to allergen avoidance [13].

Anatomical context of Evidence-Based Medicine

• The treatment of flexor tendon injuries is based on evidence-based medicine, where clinical problems and new concepts were first evaluated in the biomechanical and animal laboratories and clinical practice is dictated by long-term outcome results [14].
• METHOD: The techniques of evidence-based medicine were used to assist with treatment/coverage decisions concerning high dose chemotherapy with autologous bone marrow transplants (HDC/ABMT) for invasive breast cancer [15].

Associations of Evidence-Based Medicine with chemical compounds

• Toward individualized evidence-based medicine: five "N of 1" trials of methylphenidate in geriatric patients [16].
• In a significant proportion of cases, evidence-based medicine cannot support the current widespread continued prescription of dipyridamole in cardiological practice, but the jury is still out on cerebrovascular disease [17].
• Applying the criteria of evidence-based medicine and Hill's criteria, the evidence is not convincing for a causal relationship between therapeutic droperidol administration and life-threatening cardiac events [18].
• In view of the current emphasis on evidence-based medicine, we performed a questionnaire-based survey to establish current practice in the use of azathioprine by consultant dermatologists and associate specialists in the U.K. The response rate was 68% [19].
• Ondansetron and evidence-based medicine [20].

Gene context of Evidence-Based Medicine

• An evidence-based medicine approach to combined treatment for ADHD in children and adolescents [21].
• Because decisions regarding therapy are so common in clinical practice, the application of number needed to treat (NNT) is one of the most important evidence-based medicine skills to be acquired [22].
• Evidence-based medicine, whose philosophical origins extend back to mid-19th century Paris and earlier, is the conscientious, explicit and judicious use of current best evidence in making decisions about the care of individual patients [23].
• OBJECTIVE: To assess the attitudes of practicing general internists toward evidence-based medicine (EBM-defined as the process of systematically finding, appraising, and using contemporaneous research findings as the basis for clinical decisions) and their perceived barriers to its use [24].
• In this article, the use of botulinum toxin (BTX) in cervical dystonia is reviewed according to evidence-based medicine [25].

Analytical, diagnostic and therapeutic context of Evidence-Based Medicine

• In applying the results of a meta-analysis to individual patients, some textbooks of evidence-based medicine advocate individualizing NNT, based on the RR and the patient's expected event rate (PEER) [26].
• The author reviewed the literature regarding recombinant activated Factor VII (rFVIIa) in major abdominal surgery and liver transplantation and concluded that, on the basis of evidence-based medicine, there is no evidence to support an extensive use of rFVIIa [27].
• The need for evidence-based medicine in family planning practice is acute, as counselling for intrauterine devices and tubal sterilization attests [28].
• There's no longer any need for randomized control groups; it's time to regularly offer atropine and bifocals for school myopia; comments on evidence-based medicine [29].

References