The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
Chemical Compound Review

Magnevist     2-[2-[carboxylatomethyl-[2...

Synonyms: Magnevist (TN), CHEBI:31797, LS-70963, BAY-86-4882, AKOS015896299, ...
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of GADOPENTETATE DIMEGLUMINE

  • Imaging of myocardial infarction: comparison of magnevist and gadophrin-3 in rabbits [1].
  • Resovist was administered intravenously at doses of 4, 8, and 16 mumol of iron per kilogram of body weight [2].
  • An in vitro internalization study showed that Av-G6Gd accumulated and was internalized into SHIN3 cells (a human ovarian cancer) 50- and 3.5-fold greater than Gd-DTPA (Magnevist) and G6-(1B4M-Gd)(256) (G6Gd) [3].
  • CONCLUSIONS: The dose-dependency and rate of decay of efficacy of Resovist in cirrhosis were similar to those in normal liver, although the efficacy was less in cirrhotic liver and both the dose-dependency and rate of decay of efficacy were dependent on imaging parameters [4].
  • Gadopentetate-dimeglumine-enhanced MR imaging of gliomatosis cerebri: appearance mimicking leptomeningeal tumor dissemination [5].
 

High impact information on GADOPENTETATE DIMEGLUMINE

  • MATERIALS AND METHODS: Thirty-six patients with liver lesions received a bolus injection of Resovist (SH U 555 A; Schering, Berlin, Germany) at a dose of 4, 8, or 16 micromol iron per kilogram body weight (micromol Fe/kg) [6].
  • The latter were preferred by the colon carcinoma cell line used here and taken up much faster (12 h) than the smaller carboxydextran-coated Resovist (48 h) [7].
  • A multicompartment pharmacokinetic model was proposed to quantitatively describe the distribution of the contrast agent gadopentetate-dimeglumine (Gd) in an experimental spinal cord injury (SCI) [8].
  • The results indicate: 1) lack of uptake of Gd in normal cord tissue, 2) rapid exchange of Gd between plasma and cerebrospinal fluid in both normal and injured cord tissues, and 3) slower uptake of Gd in injured cord [8].
  • The exponential clearance rate constant, (kappa), and filtration fraction (FF) have been measured for dialysis of Gadolinium-diethylenetriaminepentaacetic acid (Gd-DTPA) (Magnevist, Berlex, Wayne, NJ) solutions by using a Look-Locker imaging technique under conditions of flow [9].
 

Chemical compound and disease context of GADOPENTETATE DIMEGLUMINE

 

Biological context of GADOPENTETATE DIMEGLUMINE

  • Application of a superparamagnetic iron oxide (Resovist) for MR imaging of human cerebral blood volume [12].
  • Using a 1.5-T Gyroscan ACS II-imager (Philips, Hamburg, Germany) and a double breast coil with the patient lying in a prone position, 0.1 mmol/kgbw Magnevist (Schering, Berlin, Germany) were injected into the cubital vein to obtain dynamic axial and coronal T1-weighted fast-field-echo images every minute up to 7 min after bolus injection [13].
 

Anatomical context of GADOPENTETATE DIMEGLUMINE

  • MRI revealed clear signal changes attributable to Resovist-containing microglia in the mouse brain [14].
  • RATIONALE AND OBJECTIVES: The objective of the two pivotal phase 3 studies was to evaluate the safety and efficacy of OptiMARK (Gd-DTPA-bis(methoxyethylamide) [Gd-DTPA-BMEA]) compared with Magnevist (Gd-DTPA) in magnetic resonance imaging of the central nervous system [15].
  • We retrospectively reviewed 330 T1-weighted sagittal images, 80 T2-weighted sagittal images, and 83 gadopentetate-dimeglumine-enhanced scans of normal adults to determine the MR appearance of the normal adult clivus [16].
  • Eleven patients with known or suspected optic nerve lesions and eight normal subjects were examined with spin-echo technique at 1.5 T with unenhanced T1-weighted imaging, IV gadopentetate-dimeglumine-enhanced T1-weighted imaging, and enhanced T1-weighted imaging with fat suppression [17].
  • After positioning a catheter in the hepatic artery, we performed 3D inversion recovery GRE MRI after IA and IV gadopentetate-dimeglumine contrast injections at doses of 0.04 and 0.1 mmol/kg, respectively [18].
 

Associations of GADOPENTETATE DIMEGLUMINE with other chemical compounds

 

Gene context of GADOPENTETATE DIMEGLUMINE

  • Resovist for imaging of hepatocellular carcinoma in the cirrhotic liver [24].
  • Seventeen patients with malignant focal liver lesions (liver metastases, n=7), hepatocellular carcinomas (HCC, n=9), and cholangiocellular carcinoma (CCC, n=1) underwent presurgical Resovist-enhanced MRI and CTAP [25].
  • Large iron oxide particles are used for bowel contrast [AMI-121 (i.e. Lumirem and Gastromark) and OMP (i.e. Abdoscan), mean diameter no less than 300 nm] and liver/spleen imaging [AMI-25 (i.e. Endorem and Feridex IV, diameter 80-150 nm); SHU 555A (i.e. Resovist, mean diameter 60 nm)] [26].
  • We then administered microglia, which were labeled with enhanced green fluorescent protein (EGFP) gene and Resovist, into the carotid artery [27].
  • MRI revealed clear signal changes attributable to Resovist-containing microglia in Abeta-injected areas [27].
 

Analytical, diagnostic and therapeutic context of GADOPENTETATE DIMEGLUMINE

References

  1. Imaging of myocardial infarction: comparison of magnevist and gadophrin-3 in rabbits. Barkhausen, J., Ebert, W., Debatin, J.F., Weinmann, H.J. J. Am. Coll. Cardiol. (2002) [Pubmed]
  2. Clinical results with Resovist: a phase 2 clinical trial. Reimer, P., Rummeny, E.J., Daldrup, H.E., Balzer, T., Tombach, B., Berns, T., Peters, P.E. Radiology. (1995) [Pubmed]
  3. Avidin-dendrimer-(1B4M-Gd)(254): a tumor-targeting therapeutic agent for gadolinium neutron capture therapy of intraperitoneal disseminated tumor which can be monitored by MRI. Kobayashi, H., Kawamoto, S., Saga, T., Sato, N., Ishimori, T., Konishi, J., Ono, K., Togashi, K., Brechbiel, M.W. Bioconjug. Chem. (2001) [Pubmed]
  4. Dose-dependency and rate of decay of efficacy of Resovist on MR images in a rat cirrhotic liver model. Kato, N., Takahashi, M., Tsuji, T., Ihara, S., Brautigam, M., Miyazawa, T. Investigative radiology. (1999) [Pubmed]
  5. Gadopentetate-dimeglumine-enhanced MR imaging of gliomatosis cerebri: appearance mimicking leptomeningeal tumor dissemination. Rippe, D.J., Boyko, O.B., Fuller, G.N., Friedman, H.S., Oakes, W.J., Schold, S.C. AJNR. American journal of neuroradiology. (1990) [Pubmed]
  6. MR imaging of the liver with Resovist: safety, efficacy, and pharmacodynamic properties. Kopp, A.F., Laniado, M., Dammann, F., Stern, W., Grönewäller, E., Balzer, T., Schimpfky, C., Claussen, C.D. Radiology. (1997) [Pubmed]
  7. Imaging of single human carcinoma cells in vitro using a clinical whole-body magnetic resonance scanner at 3.0 T. Pinkernelle, J., Teichgräber, U., Neumann, F., Lehmkuhl, L., Ricke, J., Scholz, R., Jordan, A., Bruhn, H. Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine. (2005) [Pubmed]
  8. A pharmacokinetic model for quantitative evaluation of spinal cord injury with dynamic contrast-enhanced magnetic resonance imaging. Bilgen, M., Narayana, P.A. Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine. (2001) [Pubmed]
  9. Measurement of Gd-DTPA dialysis clearance rates by using a look-locker imaging technique. Niendorf, E.R., Santyr, G.E., Brazy, P.C., Grist, T.M. Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine. (1996) [Pubmed]
  10. Changes in first-pass interstitial kinetics of DTPA in myocardium submitted to low-flow ischemia. Maskali, F., Ayalew, A., Marie, P.Y., Menu, P., Antunes, L., Mertes, P.M., Zannad, F., Gravier, J.M., Karcher, G., Bertrand, A. Investigative radiology. (2005) [Pubmed]
  11. Unusual long-standing Gd-DTPA enhancement in a chronic progressive myelopathy. Weinstock-Guttman, B., Ross, J.S., Ransohoff, R.M. Journal of computer assisted tomography. (1995) [Pubmed]
  12. Application of a superparamagnetic iron oxide (Resovist) for MR imaging of human cerebral blood volume. Reimer, P., Schuierer, G., Balzer, T., Peters, P.E. Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine. (1995) [Pubmed]
  13. Is the "blooming sign" a promising additional tool to determine malignancy in MR mammography? Fischer, D.R., Baltzer, P., Malich, A., Wurdinger, S., Freesmeyer, M.G., Marx, C., Kaiser, W.A. European radiology. (2004) [Pubmed]
  14. Magnetic resonance imaging using hemagglutinating virus of Japan-envelope vector successfully detects localization of intra-cardially administered microglia in normal mouse brain. Song, Y., Morikawa, S., Morita, M., Inubushi, T., Takada, T., Torii, R., Tooyama, I. Neurosci. Lett. (2006) [Pubmed]
  15. Magnetic resonance imaging in patients with central nervous system pathology: a comparison of OptiMARK (Gd-DTPA-BMEA) and Magnevist (Gd-DTPA). Grossman, R.I., Rubin, D.L., Hunter, G., Haughton, V.M., Lee, D., Sze, G., Kuhn, M.J., Maravilla, K., Tu, R., Heindel, W., Wippold, F.J., Leeds, N., Zelch, J., Jinkins, J.R., Grodd, W., Truwit, C., Kanal, E., Provenzale, J.M., Ramsey, R., Simon, J., Brunberg, J.A., Stevens, G.R., Kristy, R.M. Investigative radiology. (2000) [Pubmed]
  16. MR imaging of the normal and abnormal clivus. Kimura, F., Kim, K.S., Friedman, H., Russell, E.J., Breit, R. AJNR. American journal of neuroradiology. (1990) [Pubmed]
  17. MR imaging of optic nerve lesions: value of gadopentetate dimeglumine and fat-suppression technique. Hendrix, L.E., Kneeland, J.B., Haughton, V.M., Daniels, D.L., Szumowski, J., Williams, A.L., Mark, L.P., Czervionke, L.F. AJNR. American journal of neuroradiology. (1990) [Pubmed]
  18. Comparison between intravenous and intraarterial contrast injections for dynamic 3D MRI of liver tumors in the VX2 rabbit model. Larson, A.C., Rhee, T.K., Deng, J., Wang, D., Sato, K.T., Salem, R., Paunesku, T., Woloschak, G., Mulcahy, M.F., Li, D., Omary, R.A. Journal of magnetic resonance imaging : JMRI. (2006) [Pubmed]
  19. Safety of gadobenate dimeglumine (MultiHance): Summary of findings from clinical studies and postmarketing surveillance. Shellock, F.G., Parker, J.R., Venetianer, C., Pirovano, G., Spinazzi, A. Investigative radiology. (2006) [Pubmed]
  20. Magnetic resonance imaging of focal liver lesions. Comparison of the superparamagnetic iron oxide resovist versus gadolinium-DTPA in the same patient. Vogl, T.J., Hammerstingl, R., Schwarz, W., Kümmel, S., Müller, P.K., Balzer, T., Lauten, M.J., Balzer, J.O., Mack, M.G., Schimpfky, C., Schrem, H., Bechstein, W.O., Neuhaus, P., Felix, R. Investigative radiology. (1996) [Pubmed]
  21. A multicenter, randomized, double-blind study to evaluate the safety, tolerability, and efficacy of OptiMARK (gadoversetamide injection) compared with Magnevist (gadopentetate dimeglumine) in patients with liver pathology: results of a Phase III clinical trial. Rubin, D.L., Desser, T.S., Semelka, R., Brown, J., Nghiem, H.V., Stevens, W.R., Bluemke, D., Nelson, R., Fultz, P., Reimer, P., Ho, V., Kristy, R.M., Pierro, J.A. Journal of magnetic resonance imaging : JMRI. (1999) [Pubmed]
  22. Relaxivity of Gadopentetate Dimeglumine (Magnevist), Gadobutrol (Gadovist), and Gadobenate Dimeglumine (MultiHance) in human blood plasma at 0.2, 1.5, and 3 Tesla. Pintaske, J., Martirosian, P., Graf, H., Erb, G., Lodemann, K.P., Claussen, C.D., Schick, F. Investigative radiology. (2006) [Pubmed]
  23. Biliary excretion and pharmacokinetics of a gadolinium chelate used as a liver-specific contrast agent for magnetic resonance imaging in the rat. Schuhmann-Giampieri, G., Schmitt-Willich, H., Frenzel, T., Schitt-Willich H [corrected to Schmitt-Willich, H. Journal of pharmaceutical sciences. (1993) [Pubmed]
  24. Resovist for imaging of hepatocellular carcinoma in the cirrhotic liver. Weishaupt, D., Willmann, J.K., Lutz, A.M., Marincek, B. European radiology. (2004) [Pubmed]
  25. Preoperative evaluation of malignant liver tumors: comparison of unenhanced and SPIO (Resovist)-enhanced MR imaging with biphasic CTAP and intraoperative US. Vogl, T.J., Schwarz, W., Blume, S., Pietsch, M., Shamsi, K., Franz, M., Lobeck, H., Balzer, T., del Tredici, K., Neuhaus, P., Felix, R., Hammerstingl, R.M. European radiology. (2003) [Pubmed]
  26. Superparamagnetic iron oxide contrast agents: physicochemical characteristics and applications in MR imaging. Wang, Y.X., Hussain, S.M., Krestin, G.P. European radiology. (2001) [Pubmed]
  27. Comparison of MR images and histochemical localization of intra-arterially administered microglia surrounding beta-amyloid deposits in the rat brain. Song, Y., Morikawa, S., Morita, M., Inubushi, T., Takada, T., Torii, R., Kitamura, Y., Taniguchi, T., Tooyama, I. Histol. Histopathol. (2006) [Pubmed]
  28. Assessment of dynamic susceptibility contrast cerebral blood flow response to amphetamine challenge: a human pharmacological magnetic resonance imaging study at 1.5 and 4 T. Rose, S.E., Janke, A.L., Strudwick, M.W., McMahon, K.L., Chalk, J.B., Snyder, P., De zubicaray, G.I. Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine. (2006) [Pubmed]
  29. SPIO-enhanced 2D-TOF MR angiography of the portal venous system: results of an intraindividual comparison. Reimer, P., Marx, C., Rummeny, E.J., Müller, M., Lentschig, M., Balzer, T., Dietl, K.H., Sulkowski, U., Berns, T., Shamsi, K., Peters, P.E. Journal of magnetic resonance imaging : JMRI. (1997) [Pubmed]
  30. Rapid measurement of Gd-DTPA extraction fraction in a dialysis system using echo-planar imaging. Niendorf, E.R., Grist, T.M., Frayne, R., Brazy, P.C., Santyr, G.E. Medical physics. (1997) [Pubmed]
  31. Measurement of relative cerebral blood volume changes with visual stimulation by 'double-dose' gadopentetate-dimeglumine-enhanced dynamic magnetic resonance imaging. Frank, J.A., Mattay, V.S., Duyn, J., Sobering, G., Barrios, F.A., Zigun, J., Sexton, R., Kwok, P., Woo, J., Moonen, C. Investigative radiology. (1994) [Pubmed]
 
WikiGenes - Universities