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Chemical Compound Review

Gadopentetic acid     2-[2-[carboxylatomethyl-[2...

Synonyms: AC1OAGPB, CHEBI:35778, Gd(H2dtpa), TL8005415
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Disease relevance of Detapac

  • Anaphylactic shock induced by intravenous gadopentetate dimeglumine [1].
  • Clinical worsening in multiple sclerosis is associated with increased frequency and area of gadopentetate dimeglumine-enhancing magnetic resonance imaging lesions [2].
  • A T2-weighted turbo spin-echo sequence, an intermediate-weighted sequence, and a fast T1-weighted gradient-echo sequence (seven sections in 2.03 seconds) during bolus injection of 0.1 mmol gadopentetate dimeglumine per kilogram of body weight were performed [3].
  • Dynamic contrast-enhanced MR imaging was performed, and the rate constant k(ep) (s(-1)) of gadopentetate dimeglumine uptake in metastases was determined [4].
  • CONCLUSION: The T1 value remains important in more precise quantitative estimation of gadopentetate dimeglumine uptake in breast tumors, which helps improve the specificity of dynamic imaging [5].

High impact information on Detapac


Chemical compound and disease context of Detapac


Biological context of Detapac

  • A three-dimensional magnetic resonance (MR) renographic method to measure single kidney glomerular filtration rate (GFR) and split renal function was developed that is based on renal signal intensity measurements during 2-3 minutes after intravenous injection of a low dose (2 mL or 0.01 mmol/kg) of gadopentetate dimeglumine [16].
  • Gadopentetate dimeglumine was injected, and the kinetics of its penetration in the leg were studied [17].
  • PURPOSE: To evaluate the role of T2*-weighted echo-planar perfusion imaging by using a first-pass gadopentetate dimeglumine technique to determine the association of magnetic resonance (MR) imaging-derived cerebral blood volume (CBV) maps with histopathologic grading of astrocytomas and to improve the accuracy of targeting of stereotactic biopsy [18].
  • In a rat model of acute unilateral airway obstruction (n = 5), only the ventilated right lung enhanced after inhalation of gadopentetate dimeglumine [19].
  • In group 3, after in situ coinjection of gadopentetate dimeglumine and plasmid, the area of increased signal intensity revealed at ex vivo MR imaging of the muscle showed a reasonable concordance with the transfected area revealed with beta-galactosidase on histologic sections [20].

Anatomical context of Detapac


Associations of Detapac with other chemical compounds

  • METHODS: Twenty patients with angiographically proven coronary artery disease and five normal volunteers underwent both resting and stress (adenosine 140 microg/kg(-1)/min(-1)) first-pass contrast-enhanced MRI examinations (using 0.05 mmol/kg 1 of gadopentetate dimeglumine [26].
  • PURPOSE: To delineate dynamic gadopentetate dimeglumine enhancement profiles within the abdomen as a guide to improve gadolinium-enhanced magnetic resonance (MR) angiography [27].
  • RESULTS: Enhancement ratios were significantly higher for gadoteridol than for gadopentetate dimeglumine in the physis, epiphyseal cartilage, and secondary ossification center (P < .05) [28].
  • MATERIALS AND METHODS: Fifty-seven hips of 56 patients with chronic hip pain and a strong clinical suspicion of labral lesions were examined with a three-dimensional gradient-echo sequence in the coronal oblique and sagittal oblique projections before and after the intraarticular injection of gadopentetate dimeglumine [29].
  • To determine the safety and efficacy of gadopentetate dimeglumine as a bowel contrast agent, magnetic resonance (MR) imaging (0.5 T) was performed with a formulation of gadopentetate dimeglumine (1.0 mmol/L of gadopentetate dimeglumine, 15 g/L of mannitol, 6-17 mL/kg) in 133 patients with intraabdominal mass lesions [30].

Gene context of Detapac


Analytical, diagnostic and therapeutic context of Detapac


  1. Anaphylactic shock induced by intravenous gadopentetate dimeglumine. Tardy, B., Guy, C., Barral, G., Page, Y., Ollagnier, M., Bertrand, J.C. Lancet (1992) [Pubmed]
  2. Clinical worsening in multiple sclerosis is associated with increased frequency and area of gadopentetate dimeglumine-enhancing magnetic resonance imaging lesions. Smith, M.E., Stone, L.A., Albert, P.S., Frank, J.A., Martin, R., Armstrong, M., Maloni, H., McFarlin, D.E., McFarland, H.F. Ann. Neurol. (1993) [Pubmed]
  3. Discrimination of prostate cancer from normal peripheral zone and central gland tissue by using dynamic contrast-enhanced MR imaging. Engelbrecht, M.R., Huisman, H.J., Laheij, R.J., Jager, G.J., van Leenders, G.J., Hulsbergen-Van De Kaa, C.A., de la Rosette, J.J., Blickman, J.G., Barentsz, J.O. Radiology. (2003) [Pubmed]
  4. Gadopentetate dimeglumine and FDG uptake in liver metastases of colorectal carcinoma as determined with MR imaging and PET. van Laarhoven, H.W., de Geus-Oei, L.F., Wiering, B., Lok, J., Rijpkema, M., Kaanders, J.H., Krabbe, P.F., Ruers, T., Punt, C.J., van der Kogel, A.J., Oyen, W.J., Heerschap, A. Radiology. (2005) [Pubmed]
  5. Dynamic echo-planar imaging of the breast: experience in diagnosing breast carcinoma and correlation with tumor angiogenesis. Hulka, C.A., Edmister, W.B., Smith, B.L., Tan, L., Sgroi, D.C., Campbell, T., Kopans, D.B., Weisskoff, R.M. Radiology. (1997) [Pubmed]
  6. Magnetic resonance imaging-determined synovial membrane and joint effusion volumes in rheumatoid arthritis and osteoarthritis: comparison with the macroscopic and microscopic appearance of the synovium. Ostergaard, M., Stoltenberg, M., Løvgreen-Nielsen, P., Volck, B., Jensen, C.H., Lorenzen, I. Arthritis Rheum. (1997) [Pubmed]
  7. Noninvasive detection of coronary artery stenosis using contrast-enhanced three-dimensional breath-hold magnetic resonance coronary angiography. Regenfus, M., Ropers, D., Achenbach, S., Kessler, W., Laub, G., Daniel, W.G., Moshage, W. J. Am. Coll. Cardiol. (2000) [Pubmed]
  8. Idiopathic central diabetes insipidus is associated with abnormal blood supply to the posterior pituitary gland caused by vascular impairment of the inferior hypophyseal artery system. Maghnie, M., Altobelli, M., Di Iorgi, N., Genovese, E., Meloni, G., Manca-Bitti, M.L., Cohen, A., Bernasconi, S. J. Clin. Endocrinol. Metab. (2004) [Pubmed]
  9. Cytotoxicity of iodinated and gadolinium-based contrast agents in renal tubular cells at angiographic concentrations: in vitro study. Heinrich, M.C., Kuhlmann, M.K., Kohlbacher, S., Scheer, M., Grgic, A., Heckmann, M.B., Uder, M. Radiology (2007) [Pubmed]
  10. Contrast enhancement of central nervous system lesions: multicenter intraindividual crossover comparative study of two MR contrast agents. Maravilla, K.R., Maldjian, J.A., Schmalfuss, I.M., Kuhn, M.J., Bowen, B.C., Wippold, F.J., Runge, V.M., Knopp, M.V., Kremer, S., Wolansky, L.J., Anzalone, N., Essig, M., Gustafsson, L. Radiology. (2006) [Pubmed]
  11. Abdominal and iliac arterial stenoses: comparative double-blinded randomized study of diagnostic accuracy of 3D MR angiography with gadodiamide or gadopentetate dimeglumine. Schaefer, P.J., Boudghene, F.P., Brambs, H.J., Bret-Zurita, M., Caniego, J.L., Coulden, R.A., Gehl, H.B., Hammerstingl, R., Huber, A., Mendez, R.J., Nonent, M., Oestmann, J.W., Pueyo, J.C., Thurnher, S., Weishaupt, D., Jahnke, T. Radiology. (2006) [Pubmed]
  12. Coronary artery bypass graft patency: assessment with true ast imaging with steady-state precession versus gadolinium-enhanced MR angiography. Bunce, N.H., Lorenz, C.H., John, A.S., Lesser, J.R., Mohiaddin, R.H., Pennell, D.J. Radiology. (2003) [Pubmed]
  13. CO2 and gadopentetate dimeglumine as alternative contrast agents for malfunctioning dialysis grafts and fistulas. Spinosa, D.J., Angle, J.F., Hagspiel, K.D., Schenk, W.G., Matsumoto, A.H. Kidney Int. (1998) [Pubmed]
  14. Gadolinium-enhanced excretory MR urography after low-dose diuretic injection: comparison with conventional excretory urography. Nolte-Ernsting, C.C., Bücker, A., Adam, G.B., Neuerburg, J.M., Jung, P., Hunter, D.W., Jakse, G., Günther, R.W. Radiology. (1998) [Pubmed]
  15. The efficacy of gadobenate dimeglumine (Gd-BOPTA) at 3 Tesla in brain magnetic resonance imaging: comparison to 1.5 Tesla and a standard gadolinium chelate using a rat brain tumor model. Runge, V.M., Biswas, J., Wintersperger, B.J., Baumann, S.S., Jackson, C.B., Herborn, C.U., Patel, T. Investigative radiology. (2006) [Pubmed]
  16. Dynamic three-dimensional MR renography for the measurement of single kidney function: initial experience. Lee, V.S., Rusinek, H., Noz, M.E., Lee, P., Raghavan, M., Kramer, E.L. Radiology. (2003) [Pubmed]
  17. Delayed muscle injuries in arterial insufficiency: contrast-enhanced MR imaging and 31P spectroscopy in rats. Asperio, R.M., Nicolato, E., Marzola, P., Farace, P., Lunati, E., Sbarbati, A., Osculati, F. Radiology. (2001) [Pubmed]
  18. Glial neoplasms: dynamic contrast-enhanced T2*-weighted MR imaging. Knopp, E.A., Cha, S., Johnson, G., Mazumdar, A., Golfinos, J.G., Zagzag, D., Miller, D.C., Kelly, P.J., Kricheff, I.I. Radiology. (1999) [Pubmed]
  19. Contrast-enhanced MR imaging of the lung: assessments of ventilation and perfusion. Berthezène, Y., Vexler, V., Clément, O., Mühler, A., Moseley, M.E., Brasch, R.C. Radiology. (1992) [Pubmed]
  20. Electrotransfer at MR imaging: tool for optimization of gene transfer protocols--feasibility study in mice. Paturneau-Jouas, M., Parzy, E., Vidal, G., Carlier, P.G., Wary, C., Vilquin, J.T., de Kerviler, E., Schwartz, K., Leroy-Willig, A. Radiology. (2003) [Pubmed]
  21. Single-vessel coronary artery stenosis: myocardial perfusion imaging with Gadomer-17 first-pass MR imaging in a swine model of comparison with gadopentetate dimeglumine. Gerber, B.L., Bluemke, D.A., Chin, B.B., Boston, R.C., Heldman, A.W., Lima, J.A., Kraitchman, D.L. Radiology. (2002) [Pubmed]
  22. Evolving pituitary hormone deficiency is associated with pituitary vasculopathy: dynamic MR study in children with hypopituitarism, diabetes insipidus, and Langerhans cell histiocytosis. Maghnie, M., Genovese, E., Aricò, M., Villa, A., Beluffi, G., Campani, R., Severi, F. Radiology. (1994) [Pubmed]
  23. Contrast-enhanced MR Angiography of the renal arteries: blinded multicenter crossover comparison of gadobenate dimeglumine and gadopentetate dimeglumine. Prokop, M., Schneider, G., Vanzulli, A., Goyen, M., Ruehm, S.G., Douek, P., Daprà, M., Pirovano, G., Kirchin, M.A., Spinazzi, A. Radiology. (2005) [Pubmed]
  24. New directions in the development of MR imaging contrast media. Brasch, R.C. Radiology. (1992) [Pubmed]
  25. Intrathecal gadolinium-enhanced MR cisternography in the evaluation of clinically suspected cerebrospinal fluid rhinorrhea in humans: early experience. Jinkins, J.R., Rudwan, M., Krumina, G., Tali, E.T. Radiology. (2002) [Pubmed]
  26. A myocardial perfusion reserve index in humans using first-pass contrast-enhanced magnetic resonance imaging. Cullen, J.H., Horsfield, M.A., Reek, C.R., Cherryman, G.R., Barnett, D.B., Samani, N.J. J. Am. Coll. Cardiol. (1999) [Pubmed]
  27. Effect of the rate of gadopentetate dimeglumine administration on abdominal vascular and soft-tissue MR imaging enhancement patterns. Strouse, P.J., Prince, M.R., Chenevert, T.L. Radiology. (1996) [Pubmed]
  28. Gadolinium-enhanced MR images of the growing piglet skeleton: ionic versus nonionic contrast agent. Menezes, N.M., Olear, E.A., Li, X., Connolly, S.A., Zurakowski, D., Foley, M., Shapiro, F., Jaramillo, D. Radiology. (2006) [Pubmed]
  29. Lesions of the acetabular labrum: accuracy of MR imaging and MR arthrography in detection and staging. Czerny, C., Hofmann, S., Neuhold, A., Tschauner, C., Engel, A., Recht, M.P., Kramer, J. Radiology. (1996) [Pubmed]
  30. Gadopentetate dimeglumine as a bowel contrast agent: safety and efficacy. Kaminsky, S., Laniado, M., Gogoll, M., Kornmesser, W., Clauss, W., Langer, M., Claussen, C., Felix, R. Radiology. (1991) [Pubmed]
  31. Dynamic contrast-enhanced MRI of vascular changes induced by the VEGF-signalling inhibitor ZD4190 in human tumour xenografts. Checkley, D., Tessier, J.J., Wedge, S.R., Dukes, M., Kendrew, J., Curry, B., Middleton, B., Waterton, J.C. Magnetic resonance imaging. (2003) [Pubmed]
  32. Use of dynamic contrast-enhanced MRI to evaluate acute treatment with ZD6474, a VEGF signalling inhibitor, in PC-3 prostate tumours. Checkley, D., Tessier, J.J., Kendrew, J., Waterton, J.C., Wedge, S.R. Br. J. Cancer (2003) [Pubmed]
  33. Hypervascular liver lesions: differentiation of focal nodular hyperplasia from malignant tumors with dynamic gadolinium-enhanced MR imaging. Mahfouz, A.E., Hamm, B., Taupitz, M., Wolf, K.J. Radiology. (1993) [Pubmed]
  34. Gadopentetate Dimeglumine and FDG Uptake in Liver Metastases. Miles, K., Keith, C., van Laarhoven, H.W., de Geus-Oei, L.F., Wiering, B., Lok, J., Rijpkema, M., Kaanders, J.H., Krabbe, P.F., Ruers, T., Punt, C.J., van der Kogel, A.J., Oyen, W.J., Heerschap, A. Radiology. (2006) [Pubmed]
  35. Primary and secondary brain tumors at MR imaging: bicentric intraindividual crossover comparison of gadobenate dimeglumine and gadopentetate dimeglumine. Knopp, M.V., Runge, V.M., Essig, M., Hartman, M., Jansen, O., Kirchin, M.A., Moeller, A., Seeberg, A.H., Lodemann, K.P. Radiology. (2004) [Pubmed]
  36. Increases in soluble VCAM-1 correlate with a decrease in MRI lesions in multiple sclerosis treated with interferon beta-1b. Calabresi, P.A., Tranquill, L.R., Dambrosia, J.M., Stone, L.A., Maloni, H., Bash, C.N., Frank, J.A., McFarland, H.F. Ann. Neurol. (1997) [Pubmed]
  37. The relationship between partial pressure of oxygen and perfusion in two murine tumors after X-ray irradiation: a combined gadopentetate dimeglumine dynamic magnetic resonance imaging and in vivo electron paramagnetic resonance oximetry study. Goda, F., Bacic, G., O'Hara, J.A., Gallez, B., Swartz, H.M., Dunn, J.F. Cancer Res. (1996) [Pubmed]
  38. Detection and localization of proteinuria by dynamic contrast-enhanced magnetic resonance imaging using MS325. Zhang, Y., Choyke, P.L., Lu, H., Takahashi, H., Mannon, R.B., Zhang, X., Marcos, H., Li, K.C., Kopp, J.B. J. Am. Soc. Nephrol. (2005) [Pubmed]
  39. Coronary MR angiography: experimental results with a monomer-stabilized blood pool contrast medium. Taupitz, M., Schnorr, J., Wagner, S., Abramjuk, C., Pilgrimm, H., Kivelitz, D., Schink, T., Hansel, J., Laub, G., Hünigen, H., Hamm, B. Radiology. (2002) [Pubmed]
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