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Chemical Compound Review

Diclofenac potassium     potassium2-[2-[(2,6- dichlorophenyl)amino]...

Synonyms:
 
 
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Disease relevance of Diclophenac

 

High impact information on Diclophenac

 

Chemical compound and disease context of Diclophenac

  • In a double-blind, placebo-controlled comparative study in 60 patients with ankle sprains suffering from moderate to severe inflammation and tenderness, the efficacy and tolerability of 150 mg/day diclofenac potassium given for 7 days was superior to that of 1.2 g/day ibuprofen which was, in turn, superior to placebo [9].
 

Anatomical context of Diclophenac

 

Associations of Diclophenac with other chemical compounds

 

Gene context of Diclophenac

  • In a single dose cross-over study with 12 healthy male volunteers the plasma concentrations of diclofenac (CAS 15307-86-5) and codeine (CAS 76-57-3) were determined after oral and rectal application of formulations containing 50 mg of each drug [14].
 

Analytical, diagnostic and therapeutic context of Diclophenac

References

  1. Diclofenac-potassium in migraine: a review. McNeely, W., Goa, K.L. Drugs (1999) [Pubmed]
  2. An observer-blind comparison of diclofenac potassium, piroxicam and placebo in the treatment of ankle sprains. Morán, M. Current medical research and opinion. (1990) [Pubmed]
  3. Low-dose diclofenac potassium in the treatment of episodic tension-type headache. Kubitzek, F., Ziegler, G., Gold, M.S., Liu, J.M., Ionescu, E. European journal of pain (London, England) (2003) [Pubmed]
  4. Comparison of the analgesic effect of betamethasone and diclofenac potassium in the management of postoperative haemorrhoidectomy pain. Kisli, E., Başer, M., Güler, O., Aydin, M., Kati, I. Acta chirurgica Belgica. (2005) [Pubmed]
  5. Analgesic efficacy and safety of lornoxicam quick-release formulation compared with diclofenac potassium: randomised, double-blind trial in acute low back pain. Yakhno, N., Guekht, A., Skoromets, A., Spirin, N., Strachunskaya, E., Ternavsky, A., Olsen, K.J., Moller, P.L. Clinical drug investigation (2006) [Pubmed]
  6. Bioavailability of diclofenac potassium at low doses. Hinz, B., Chevts, J., Renner, B., Wuttke, H., Rau, T., Schmidt, A., Szelenyi, I., Brune, K., Werner, U. British journal of clinical pharmacology. (2005) [Pubmed]
  7. Efficacy and tolerability of diclofenac potassium sachets in acute postoperative dental pain: a placebo-controlled, randomised, comparative study vs. diclofenac potassium tablets. Hofele, C.M., Gyenes, V., Daems, L.N., Stypula-Ciuba, B., Wagener, H., Siegel, J., Edson, K. International journal of clinical practice. (2006) [Pubmed]
  8. Effects of co-administered dexamethasone and diclofenac potassium on pain, swelling and trismus following third molar surgery. Bamgbose, B.O., Akinwande, J.A., Adeyemo, W.L., Ladeinde, A.L., Arotiba, G.T., Ogunlewe, M.O. Head & face medicine [electronic resource]. (2005) [Pubmed]
  9. Double-blind comparison of diclofenac potassium, ibuprofen and placebo in the treatment of ankle sprains. Morán, M. J. Int. Med. Res. (1991) [Pubmed]
  10. Passive and iontophoretic delivery of three diclofenac salts across various skin types. Fang, J., Wang, R., Huang, Y., Wu, P.C., Tsai, Y. Biol. Pharm. Bull. (2000) [Pubmed]
  11. Determination of diclofenac in micro-whole blood samples by high-performance liquid chromatography with electrochemical detection. Application in a pharmacokinetic study. Torres-López, J.E., Robles, M.B., Pérez-Urizar, J., Flores-Murrieta, F.J., Granados-Soto, V. Arzneimittel-Forschung. (1997) [Pubmed]
  12. Diclofenac potassium in the management of dental pain: a multicenter double-blind comparison with glafenine. Boghdady, W., Lotfy, M., William, E. Egyptian dental journal. (1993) [Pubmed]
  13. Increased absorption rate of diclofenac from fast acting formulations containing its potassium salt. Reiner, V., Reiner, A., Reiner, G., Conti, M. Arzneimittel-Forschung. (2001) [Pubmed]
  14. Pharmacokinetics and drug input characteristics for a diclofenac-codeine phosphate combination following oral and rectal administration. Hanses, A., Spahn-Langguth, H., Meiss, F., Mutschler, E. Arzneimittel-Forschung. (1996) [Pubmed]
  15. Efficacy and tolerability of diclofenac potassium sachets in migraine: a randomized, double-blind, cross-over study in comparison with diclofenac potassium tablets and placebo. Diener, H.C., Montagna, P., Gács, G., Lyczak, P., Schumann, G., Zöller, B., Mulder, L., Siegel, J., Edson, K. Cephalalgia : an international journal of headache. (2006) [Pubmed]
  16. Onset and duration of analgesia of diclofenac potassium in the treatment of postepisiotomy pain. Olson, N.Z., Sunshine, A., Zighelboim, I., DeCastro, A. American journal of therapeutics. (1997) [Pubmed]
  17. Diclofenac potassium for the treatment of traumatic joint distortions: an open multicentre study. Verstraeten, A., Bakshi, R. J. Int. Med. Res. (1991) [Pubmed]
 
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