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Chemical Compound Review

Ortofen     sodium2-[2-[(2,6- dichlorophenyl)amino]phe...

Synonyms:
 
 
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Disease relevance of Diclophenac

 

Psychiatry related information on Diclophenac

 

High impact information on Diclophenac

 

Chemical compound and disease context of Diclophenac

 

Biological context of Diclophenac

 

Anatomical context of Diclophenac

  • When expressed relative to T3, DCF was 135-fold more potent in cytosol than in nuclear extract [19].
  • In the present study we have examined the competitive potency for DCF and its effect on nuclear binding of T3 in cultured cells [19].
  • Diclofenac sodium (Voltaren) reduced exercise-induced injury in human skeletal muscle [21].
  • Responses to TNP-Ficoll were measured in the popliteal lymph node of BALB/c mice three weeks after they received a single oral dose of D-Pen or DF [22].
  • At the end of the scintigraphic imaging studies it was observed that radiolabelled lipogelosome formulation containing DFNa (L1J1) retained much longer in the experimentally arthritic knee joints of the rabbits [23].
 

Associations of Diclophenac with other chemical compounds

  • On the other hand, biofilm produced by the slime-positive, antigen-negative strain showed dramatic alterations already after short treatments with sodium diclofenac as reported for salicylate and other nonsteroidal drugs [24].
  • CONCLUSIONS: While topical NSAIDs as a class may be associated with severe adverse events, such events appeared to require potentiation in the form of high total doses, ocular comorbidities, or both with Acular and Voltaren [25].
  • RESULTS: At 10 microM, ACLO, NIM, 4-HONIM, 4-HOA-CLO, and DICLO decreased luminol-enhanced CL generated by PMA-activated neutrophils [26].
  • A double-blind placebo-controlled study was performed to assess the analgesic effect of rectal sodium diclofenac 100 mg after Caesarean section using subarachnoid hyperbaric bupivacaine 0.5% and morphine 0.2 mg [27].
  • The buccal delivery of the nonsteroidal antiinflammatory drug, diclofenac sodium (Voltaren), from a prototype hydrogel was studied in man in a randomized crossover design of buccal delivery and i.v. infusion [28].
 

Gene context of Diclophenac

 

Analytical, diagnostic and therapeutic context of Diclophenac

References

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  2. Preoperative irradiation versus the use of nonsteroidal anti-inflammatory drugs for prevention of heterotopic ossification following total hip replacement: the results of a randomized trial. Kölbl, O., Knelles, D., Barthel, T., Raunecker, F., Flentje, M., Eulert, J. Int. J. Radiat. Oncol. Biol. Phys. (1998) [Pubmed]
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  13. Allergic contact dermatitis from polyethylene glycol monomethyl ether 350 in Solaraze gel. Taibjee, S.M., Prais, L., Foulds, I.S. Contact Derm. (2003) [Pubmed]
  14. Inflammation-mediated retinal edema in the rabbit is inhibited by topical nepafenac. Kapin, M.A., Yanni, J.M., Brady, M.T., McDonough, T.J., Flanagan, J.G., Rawji, M.H., Dahlin, D.C., Sanders, M.E., Gamache, D.A. Inflammation (2003) [Pubmed]
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  16. Diclofenac sodium, 0.1% (Voltaren Ophtha), versus sodium chloride, 5%, in the treatment of filamentary keratitis. Avisar, R., Robinson, A., Appel, I., Yassur, Y., Weinberger, D. Cornea (2000) [Pubmed]
  17. In vivo and in vitro diclofenac sodium evaluation after rectal application of soft gelatine capsules enabling application induced transformation (AIT) into a semisolid system of liquid crystals (SSLC) for controlled release. Schneeweis, A., Müller-Goymann, C.C. Pharm. Res. (1997) [Pubmed]
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  19. Preferential inhibition of cytoplasmic T3 binding is associated with reduced nuclear binding in cultured cells. Barlow, J.W., Raggatt, L.E., Scholz, G.H., Loidl, N.M., Blok, R.B., Topliss, D.J., Stockigt, J.R. Thyroid (1996) [Pubmed]
  20. Effect of diclofenac sodium (Voltaren) on spermatogenesis of infertile oligospermic patients. Moskovitz, B., Lin, R., Nassar, S., Levin, D.R. Eur. Urol. (1988) [Pubmed]
  21. Diclofenac sodium (Voltaren) reduced exercise-induced injury in human skeletal muscle. O'Grady, M., Hackney, A.C., Schneider, K., Bossen, E., Steinberg, K., Douglas, J.M., Murray, W.J., Watkins, W.D. Medicine and science in sports and exercise. (2000) [Pubmed]
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