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Chemical Compound Review

Ortofen     sodium2-[2-[(2,6- dichlorophenyl)amino]phe...

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Disease relevance of Diclophenac


Psychiatry related information on Diclophenac


High impact information on Diclophenac


Chemical compound and disease context of Diclophenac


Biological context of Diclophenac


Anatomical context of Diclophenac

  • When expressed relative to T3, DCF was 135-fold more potent in cytosol than in nuclear extract [19].
  • In the present study we have examined the competitive potency for DCF and its effect on nuclear binding of T3 in cultured cells [19].
  • Diclofenac sodium (Voltaren) reduced exercise-induced injury in human skeletal muscle [21].
  • Responses to TNP-Ficoll were measured in the popliteal lymph node of BALB/c mice three weeks after they received a single oral dose of D-Pen or DF [22].
  • At the end of the scintigraphic imaging studies it was observed that radiolabelled lipogelosome formulation containing DFNa (L1J1) retained much longer in the experimentally arthritic knee joints of the rabbits [23].

Associations of Diclophenac with other chemical compounds

  • On the other hand, biofilm produced by the slime-positive, antigen-negative strain showed dramatic alterations already after short treatments with sodium diclofenac as reported for salicylate and other nonsteroidal drugs [24].
  • CONCLUSIONS: While topical NSAIDs as a class may be associated with severe adverse events, such events appeared to require potentiation in the form of high total doses, ocular comorbidities, or both with Acular and Voltaren [25].
  • RESULTS: At 10 microM, ACLO, NIM, 4-HONIM, 4-HOA-CLO, and DICLO decreased luminol-enhanced CL generated by PMA-activated neutrophils [26].
  • A double-blind placebo-controlled study was performed to assess the analgesic effect of rectal sodium diclofenac 100 mg after Caesarean section using subarachnoid hyperbaric bupivacaine 0.5% and morphine 0.2 mg [27].
  • The buccal delivery of the nonsteroidal antiinflammatory drug, diclofenac sodium (Voltaren), from a prototype hydrogel was studied in man in a randomized crossover design of buccal delivery and i.v. infusion [28].

Gene context of Diclophenac


Analytical, diagnostic and therapeutic context of Diclophenac


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  2. Preoperative irradiation versus the use of nonsteroidal anti-inflammatory drugs for prevention of heterotopic ossification following total hip replacement: the results of a randomized trial. Kölbl, O., Knelles, D., Barthel, T., Raunecker, F., Flentje, M., Eulert, J. Int. J. Radiat. Oncol. Biol. Phys. (1998) [Pubmed]
  3. Double blind randomized controlled trial of sodium meclofenamate (Meclomen) and diclofenac sodium (Voltaren): post validation reapplication of the WOMAC Osteoarthritis Index. Bellamy, N., Kean, W.F., Buchanan, W.W., Gerecz-Simon, E., Campbell, J. J. Rheumatol. (1992) [Pubmed]
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  9. Identification of anti-inflammatory drugs according to their capacity to suppress type-1 and type-2 T cell profiles. Moed, H., Stoof, T.J., Boorsma, D.M., von Blomberg, B.M., Gibbs, S., Bruynzeel, D.P., Scheper, R.J., Rustemeyer, T. Clin. Exp. Allergy (2004) [Pubmed]
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  11. Interaction of myeloperoxidase with diclofenac. Inhibition of the chlorinating activity of myeloperoxidase by diclofenac and oxidation of diclofenac to dihydroxyazobenzene by myeloperoxidase. Zuurbier, K.W., Bakkenist, A.R., Fokkens, R.H., Nibbering, N.M., Wever, R., Muijsers, A.O. Biochem. Pharmacol. (1990) [Pubmed]
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  13. Allergic contact dermatitis from polyethylene glycol monomethyl ether 350 in Solaraze gel. Taibjee, S.M., Prais, L., Foulds, I.S. Contact Derm. (2003) [Pubmed]
  14. Inflammation-mediated retinal edema in the rabbit is inhibited by topical nepafenac. Kapin, M.A., Yanni, J.M., Brady, M.T., McDonough, T.J., Flanagan, J.G., Rawji, M.H., Dahlin, D.C., Sanders, M.E., Gamache, D.A. Inflammation (2003) [Pubmed]
  15. The effect of diclofenac acid (Voltaren) on bleomycin-induced pulmonary fibrosis in hamsters. Chandler, D.B., Young, K. Prostaglandins Leukot. Essent. Fatty Acids (1989) [Pubmed]
  16. Diclofenac sodium, 0.1% (Voltaren Ophtha), versus sodium chloride, 5%, in the treatment of filamentary keratitis. Avisar, R., Robinson, A., Appel, I., Yassur, Y., Weinberger, D. Cornea (2000) [Pubmed]
  17. In vivo and in vitro diclofenac sodium evaluation after rectal application of soft gelatine capsules enabling application induced transformation (AIT) into a semisolid system of liquid crystals (SSLC) for controlled release. Schneeweis, A., Müller-Goymann, C.C. Pharm. Res. (1997) [Pubmed]
  18. Pharmacokinetic and local tissue disposition of [14C]sodium diclofenac following iontophoresis and systemic administration in rabbits. Hui, X., Anigbogu, A., Singh, P., Xiong, G., Poblete, N., Liu, P., Maibach, H.I. Journal of pharmaceutical sciences. (2001) [Pubmed]
  19. Preferential inhibition of cytoplasmic T3 binding is associated with reduced nuclear binding in cultured cells. Barlow, J.W., Raggatt, L.E., Scholz, G.H., Loidl, N.M., Blok, R.B., Topliss, D.J., Stockigt, J.R. Thyroid (1996) [Pubmed]
  20. Effect of diclofenac sodium (Voltaren) on spermatogenesis of infertile oligospermic patients. Moskovitz, B., Lin, R., Nassar, S., Levin, D.R. Eur. Urol. (1988) [Pubmed]
  21. Diclofenac sodium (Voltaren) reduced exercise-induced injury in human skeletal muscle. O'Grady, M., Hackney, A.C., Schneider, K., Bossen, E., Steinberg, K., Douglas, J.M., Murray, W.J., Watkins, W.D. Medicine and science in sports and exercise. (2000) [Pubmed]
  22. Development of an oral exposure mouse model to predict drug-induced hypersensitivity reactions by using reporter antigens. Nierkens, S., Aalbers, M., Bol, M., van Wijk, F., Hassing, I., Pieters, R. Toxicol. Sci. (2005) [Pubmed]
  23. Scintigraphic imaging of radiolabelled drug delivery systems in rabbits with arthritis. Türker, S., Erdoğan, S., Ozer, A.Y., Ergün, E.L., Tuncel, M., Bilgili, H., Deveci, S. International journal of pharmaceutics. (2005) [Pubmed]
  24. Alteration of organized structure of biofilm formed by Staphylococcus epidermidis on soft contact lenses. Perilli, R., Marziano, M.L., Formisano, G., Caiazza, S., Scorcia, G., Baldassarri, L. J. Biomed. Mater. Res. (2000) [Pubmed]
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  28. Human transbuccal absorption of diclofenac sodium from a prototype hydrogel delivery device. Cassidy, J., Berner, B., Chan, K., John, V., Toon, S., Holt, B., Rowland, M. Pharm. Res. (1993) [Pubmed]
  29. Effects of nimesulide and sodium diclofenac on interleukin-6, interleukin-8, proteoglycans and prostaglandin E2 production by human articular chondrocytes in vitro. Henrotin, Y.E., Labasse, A.H., Simonis, P.E., Zheng, S.X., Deby, G.P., Famaey, J.P., Crielaard, J.M., Reginster, J.Y. Clinical and experimental rheumatology. (1999) [Pubmed]
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  32. Somatostatin is increased in the dorsal root ganglia of adjuvant-inflamed rat. Ohno, H., Kuraishi, Y., Nanayama, T., Minami, M., Kawamura, M., Satoh, M. Neurosci. Res. (1990) [Pubmed]
  33. Use of topical nonsteroidal anti-inflammatory drugs in excimer laser photorefractive keratectomy. Arshinoff, S., D'Addario, D., Sadler, C., Bilotta, R., Johnson, T.M. Journal of cataract and refractive surgery. (1994) [Pubmed]
  34. Efficacy of diclofenac sodium ophthalmic solution versus placebo in reducing inflammation following cataract extraction and posterior chamber lens implantation. Kraff, M.C., Martin, R.G., Neumann, A.C., Weinstein, A.J. Journal of cataract and refractive surgery. (1994) [Pubmed]
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