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Chemical Compound Review

Taurocholate     2-[[(4R)-4-[ (3R,5S,7R,8S,9S,10S,12S,13R...

Synonyms: Cholyltaurine, Cholaic acid, CHEMBL224867, HSDB 832, AG-H-26395, ...
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High impact information on Taurocholate

  • The animals that received MNNG and bile or sodium taurocholate (CAS: 145-42-6; N-choloyltaurine sodium salt) had a significantly higher incidence of hyperplastic and neoplastic lesions in the stomach mucosa than did the relevant MNNG-treated controls [1].
  • Study group B (6 dogs): (1) ATS, (2) ATS + S + the beta adrenergic agonist, isoproterenol, 1.5 microng per kg-min infused into the splenic artery, and (3) ATS + S + TC + isoproterenol [2].
  • Addition of TCA increased PKC alpha specific activity with EC50 of approximately 400 nM; maximal activity was observed with 5 microM [3].
  • Conversely, the electroneutral portion of the BSP uptake was inhibited with an inhibition constant (Ki, microM) of 230 +/- 40 for C, 103 +/- 33 for TC, 99 +/- 34 for UDC and 120 +/- 39 for TUDC, respectively (means +/- SD, N = 4) [4].
  • Amiloride inhibited Na(+)-dependent uptake of cholate and TC only when hepatocytes were preincubated with amiloride, indicating an indirect effect of amiloride [5].

Biological context of Taurocholate

  • The uptake of estradiol-17 beta(beta-D-glucuronide) (E(2)17G), estriol-16 alpha(beta-D-glucuronide (E(3)16G), estradiol-17 beta-3-(beta-D-glucuronide) (E(2)3G) and taurocholate (TC) into hepatocytes isolated from male and female rats was examined and found to be linear for at least 75 sec and to exhibit Michaelis-Menten kinetics [6].

Associations of Taurocholate with other chemical compounds


Gene context of Taurocholate

  • At high [PC], RIM had lower [PC] relative to the control, while the concentration of TC was largely independent of mucin concentration [7].

Analytical, diagnostic and therapeutic context of Taurocholate

  • Intravenous TC administration before and/or during liver perfusions induced a dose-dependent recovery of DNA synthesis in the F group [10].
  • Cryo-transmission electron microscopy of phase transitions initiated by addition of TC to phospholipid vesicles revealed extremely long SM-containing intermediate structures, but shorter EYPC-containing intermediate structures [9].


  1. Enhancing effect of bile and bile acid on stomach tumorigenesis induced by N-methyl-N'-nitro-N-nitrosoguanidine in Wistar rats. Kobori, O., Shimizu, T., Maeda, M., Atomi, Y., Watanabe, J., Shoji, M., Morioka, Y. J. Natl. Cancer Inst. (1984) [Pubmed]
  2. Influence of isoproterenol and cholestyramine on acute gastric mucosal ulcerogenesis. Ritchie, W.P., Shearburn, E.W. Gastroenterology (1977) [Pubmed]
  3. Activation of protein kinase C alpha and delta by bile acids: correlation with bile acid structure and diacylglycerol formation. Rao, Y.P., Stravitz, R.T., Vlahcevic, Z.R., Gurley, E.C., Sando, J.J., Hylemon, P.B. J. Lipid Res. (1997) [Pubmed]
  4. Competition of bile acids on the sulfobromophthalein uptake in basolateral rat liver plasma membrane vesicles. Torres, A.M., Galan, A.I., Tiribelli, C. Biochem. Pharmacol. (1994) [Pubmed]
  5. Mechanism of inhibition of hepatic bile acid uptake by amiloride and 4,4'-diisothiocyano-2,2'-disulfonic stilbene (DIDS). Anwer, M.S., Branson, A.U., Atkinson, J.M. Biochem. Pharmacol. (1991) [Pubmed]
  6. Characterization of uptake of steroid glucuronides into isolated male and female rat hepatocytes. Brock, W.J., Vore, M. J. Pharmacol. Exp. Ther. (1984) [Pubmed]
  7. Analysis of the diffusion of bile salt/phospholipid micelles in rat intestinal mucin. Wiedmann, T.S., Herrington, H., Deye, C., Kallick, D. Chem. Phys. Lipids (2001) [Pubmed]
  8. Carrier-mediated hepatic uptake of the cationic cyclopeptide, octreotide, in rats. Comparison between in vivo and in vitro. Yamada, T., Niinuma, K., Lemaire, M., Terasaki, T., Sugiyama, Y. Drug Metab. Dispos. (1997) [Pubmed]
  9. Different interactions of egg-yolk phosphatidylcholine and sphingomyelin with detergent bile salts. Nibbering, C.P., Frederik, P.M., van Berge-Henegouwen, G.P., van Veen, H.A., van Marle, J., van Erpecum, K.J. Biochim. Biophys. Acta (2002) [Pubmed]
  10. Evidence for dual effect of bile acids on thymidine anabolism and catabolism by the regenerating rat liver. Villanueva, G.R., Monte, M.J., Barbero, E.R., Serrano, M.A., Marin, J.J. Biochim. Biophys. Acta (1996) [Pubmed]
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