High impact information on Taurocholate

• The animals that received MNNG and bile or sodium taurocholate (CAS: 145-42-6; N-choloyltaurine sodium salt) had a significantly higher incidence of hyperplastic and neoplastic lesions in the stomach mucosa than did the relevant MNNG-treated controls [1].
• Study group B (6 dogs): (1) ATS, (2) ATS + S + the beta adrenergic agonist, isoproterenol, 1.5 microng per kg-min infused into the splenic artery, and (3) ATS + S + TC + isoproterenol [2].
• Addition of TCA increased PKC alpha specific activity with EC50 of approximately 400 nM; maximal activity was observed with 5 microM [3].
• Conversely, the electroneutral portion of the BSP uptake was inhibited with an inhibition constant (Ki, microM) of 230 +/- 40 for C, 103 +/- 33 for TC, 99 +/- 34 for UDC and 120 +/- 39 for TUDC, respectively (means +/- SD, N = 4) [4].
• Amiloride inhibited Na(+)-dependent uptake of cholate and TC only when hepatocytes were preincubated with amiloride, indicating an indirect effect of amiloride [5].

Biological context of Taurocholate

• The uptake of estradiol-17 beta(beta-D-glucuronide) (E(2)17G), estriol-16 alpha(beta-D-glucuronide (E(3)16G), estradiol-17 beta-3-(beta-D-glucuronide) (E(2)3G) and taurocholate (TC) into hepatocytes isolated from male and female rats was examined and found to be linear for at least 75 sec and to exhibit Michaelis-Menten kinetics [6].

Associations of Taurocholate with other chemical compounds

• The interaction of sodium taurocholate/egg phosphatidylcholine (TC/PC) micelles with mucin was determined to investigate the exclusion of lipids by mucus in the absorption process [7].
• In conclusion, we have demonstrated in vivo that carrier-mediated hepatic uptake of octreotide is inhibited by TCA and DBSP and that the CLup obtained in vivo is comparable with the CLup obtained in vitro in isolated hepatocytes and primary cultured hepatocytes [8].
• Micelles were also separated from vesicular phases in two-phase model systems composed with TC, both EYPC and EYSM and 0, 10, 20 or 30 mol% cholesterol, by ultracentrifugation and ultrafiltration of the supernatant [9].

Gene context of Taurocholate

• At high [PC], RIM had lower [PC] relative to the control, while the concentration of TC was largely independent of mucin concentration [7].

Analytical, diagnostic and therapeutic context of Taurocholate

• Intravenous TC administration before and/or during liver perfusions induced a dose-dependent recovery of DNA synthesis in the F group [10].
• Cryo-transmission electron microscopy of phase transitions initiated by addition of TC to phospholipid vesicles revealed extremely long SM-containing intermediate structures, but shorter EYPC-containing intermediate structures [9].

References