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Chemical Compound Review

Pinocembrin     (2S)-5,7-dihydroxy-2-phenyl- chroman-4-one

Synonyms: Dihydrochrysin, CHEMBL399910, AG-J-60469, BSPBio_003329, KBioGR_002249, ...
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High impact information on NSC 43318


Anatomical context of NSC 43318

  • The vasorelaxant effect of pinocembrin relied on intact endothelium partially, and incubation with n(omega)-nitro-l-arginine methyl ester (l-NAME, 100 muM) or methylene blue (10 muM) significantly inhibited the effect, however indomethacin (5 muM) had no influence on the action [5].

Associations of NSC 43318 with other chemical compounds


Gene context of NSC 43318

  • Among the compounds tested pinocembrin and caffeic, ferulic, cinnamic and chlorogenic acids did not affect the activity of COX isoforms [9].
  • Caffeic, ferulic, cinnamic and chlorogenic acids and pinocembrin, (0.1-100 microM) did not affect COX activity [10].


  1. Effect of naturally occurring flavonoids on lipid peroxidation and membrane permeability transition in mitochondria. Santos, A.C., Uyemura, S.A., Lopes, J.L., Bazon, J.N., Mingatto, F.E., Curti, C. Free Radic. Biol. Med. (1998) [Pubmed]
  2. Metabolic engineering of the phenylpropanoid pathway in Saccharomyces cerevisiae. Jiang, H., Wood, K.V., Morgan, J.A. Appl. Environ. Microbiol. (2005) [Pubmed]
  3. Protections of pinocembrin on brain mitochondria contribute to cognitive improvement in chronic cerebral hypoperfused rats. Guang, H.M., Du, G.H. Eur. J. Pharmacol. (2006) [Pubmed]
  4. Assessment of the anti-inflammatory activity and free radical scavenger activity of tiliroside. Sala, A., Recio, M.C., Schinella, G.R., Máñez, S., Giner, R.M., Cerdá-Nicolás, M., Rosí, J.L. Eur. J. Pharmacol. (2003) [Pubmed]
  5. Endothelium-dependent and -independent relaxation induced by pinocembrin in rat aortic rings. Zhu, X.M., Fang, L.H., Li, Y.J., Du, G.H. Vascul. Pharmacol. (2007) [Pubmed]
  6. Propolis from the northwest of Argentina as a source of antifungal principles. Quiroga, E.N., Sampietro, D.A., Soberón, J.R., Sgariglia, M.A., Vattuone, M.A. J. Appl. Microbiol. (2006) [Pubmed]
  7. Quantitative high-performance liquid chromatography analyses of flavonoids in Australian Eucalyptus honeys. Yao, L., Jiang, Y., D'Arcy, B., Singanusong, R., Datta, N., Caffin, N., Raymont, K. J. Agric. Food Chem. (2004) [Pubmed]
  8. Analysis of propolis from the continental and Adriatic regions of Croatia. Kosalec, I., Bakmaz, M., Pepeljnjak, S. Acta pharmaceutica (Zagreb, Croatia) (2003) [Pubmed]
  9. The inhibitory effect of propolis and caffeic acid phenethyl ester on cyclooxygenase activity in J774 macrophages. Rossi, A., Ligresti, A., Longo, R., Russo, A., Borrelli, F., Sautebin, L. Phytomedicine (2002) [Pubmed]
  10. The role of the phenethyl ester of caffeic acid (CAPE) in the inhibition of rat lung cyclooxygenase activity by propolis. Rossi, A., Longo, R., Russo, A., Borrelli, F., Sautebin, L. Fitoterapia (2002) [Pubmed]
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