Disease relevance of p-Chloronitrobenzene

• Novel partial reductive pathway for 4-chloronitrobenzene and nitrobenzene degradation in Comamonas sp. strain CNB-1 [1].
• Bacterial strain LW1, which belongs to the family Comamonadaceae, utilizes 1-chloro-4-nitrobenzene (1C4NB) as a sole source of carbon, nitrogen, and energy [2].
• Characterization of genes involved in the initial reactions of 4-chloronitrobenzene degradation in Pseudomonas putida ZWL73 [3].
• These data suggest that the toxicity of ONCB is comparable to that of its structural analog, p-nitrochlorobenzene [4].

High impact information on p-Chloronitrobenzene

• Furthermore, based on the obtained structure-activity relationships, it was possible to predict the kcat/Km values of the four GST isoenzymes and the ks of the base-catalysed GSH conjugation of 1-chloro-4-nitrobenzene [5].
• Gnotobiotic and outdoor experiments showed that pollutant 4CNB was completely removed within 1 or 2 days after 4CNB application into soil, and that its phytotoxicity to alfalfa was eliminated by inoculation of strain CNB-1 [6].
• Comamonas sp. strain CNB-1 grows on 4-chloronitrobenzene (4-CNB) and nitrobenzene as sole carbon and nitrogen sources [1].
• The pharmacokinetics of p-chloronitrobenzene (p-CNB) was evaluated in rats to propose an index for monitoring p-CNB exposure of humans exposed to it [7].
• Effect of dose on the percutaneous absorption of 2- and 4-chloronitrobenzene in rats [8].

Biological context of p-Chloronitrobenzene

• Thirteen-week inhalation toxicity of 2- and 4-chloronitrobenzene in F344/N rats and B6C3F1 mice [9].
• Based on the exposure concentrations evaluated, A no-observed-adverse-effect level (NOAEL) for histopathological injury in mice was 4.5 ppm for 2-chloronitrobenzene and 6 ppm for 4-chloronitrobenzene; a NOAEL was not determined for rats [9].

Anatomical context of p-Chloronitrobenzene

• Acute and subchronic immunotoxicity of p-chloronitrobenzene in mice. I. Effect on natural killer, cytotoxic T-lymphocyte activities and mitogen-stimulated lymphocyte proliferation [10].

Associations of p-Chloronitrobenzene with other chemical compounds

• The residues found included 2-, 3-, and 4-chloronitrobenzene and 2,3- and 3,4-dichloronitrobenzene; identity was confirmed by GC/mass spectrometry [11].

Analytical, diagnostic and therapeutic context of p-Chloronitrobenzene

• Determination of p-chloronitrobenzene in plasma by reversed-phase high-performance liquid chromatography [12].
• A simple, accurate and precise isocratic reversed-phase high-performance liquid chromatographic method (HPLC) using ultraviolet detection was developed for the determination of p-chloronitrobenzene (p-CNB) and seven of its metabolites in rat urine [13].
• Acute immunotoxicity of p-chloronitrobenzene in mice: II. Effect of p-chloronitrobenzene on the immunophenotype of murine splenocytes determined by flow cytometry [14].

References