Disease relevance of Chloro-o-nitrobenzene

• Degradation of chloronitrobenzenes by a coculture of Pseudomonas putida and a Rhodococcus sp [1].
• Comamonas sp. strain CNB-1 degrades nitrobenzene and chloronitrobenzene via the intermediates 2-aminomuconate and 2-amino-5-chloromuconate, respectively [2].
• Toxicity induced by the various chloronitrobenzene isomers in vivo includes hematotoxicity, immunotoxicity, hepatotoxicity and nephrotoxicity [3].

High impact information on Chloro-o-nitrobenzene

• The catalyzed reactions of GSH with organic nitrate and thiocyanate esters and with a series of chloronitrobenzene substrates have been investigated and the results used to formulate a mechanism for glutathione S-transferase catalysis [4].
• Its catalytic efficiency with several chloronitrobenzene substrates was 20-90-fold lower than that of wild-type GST A1-1, but fully comparable to naturally evolved GSTs of different classes, providing a 10(5)-fold rate enhancement over the uncatalyzed reaction [5].
• A Novel Deaminase Involved in Chloronitrobenzene and Nitrobenzene Degradation with Comamonas sp. Strain CNB-1 [2].
• Ag/SiO2: a novel catalyst with high activity and selectivity for hydrogenation of chloronitrobenzenes [6].
• Metabolism of chloronitrobenzenes by isolated rat hepatocytes [7].

Chemical compound and disease context of Chloro-o-nitrobenzene

• Phylogenetic analyses on sequences of chloronitrobenzene nitroreductase and hydroxylaminobenzene mutase revealed that these two enzymes are closely related to the functionally identified nitrobenzene nitroreductase and hydroxylaminobenzene mutase from Pseudomonas strains JS45 and HS12 [8].

Biological context of Chloro-o-nitrobenzene

• DNA damage induced in vivo in various tissues by nitrochlorobenzene derivatives [9].
• DNA-repair synthesis, elicited by nitrochlorobenzene treatment, was also estimated 24 and 48 h after the withdrawal of the nitro-aryl halides [10].
• On the other hand, chloronitrobenzene compounds were mutagenic for base-pair substitution strains only [11].
• Two isomers of nitrochlorobenzene (o-, and p-NCB) were treated by a Pd/Fe catalyst in aqueous solutions through catalytic amination and dechlorination [12].
• Assessment of toxicity of o-nitrochlorobenzene in rats following a 4-week inhalation exposure [13].

Anatomical context of Chloro-o-nitrobenzene

• Cultured keratinocytes from 16 of 20 adult donors (80%) responded to nitrochlorobenzene in vitro by increasing CD80 transcriptional activity, thus predicting subsequent sensitization to this same hapten (chi2= 7.2, P <0.0073) [14].

Associations of Chloro-o-nitrobenzene with other chemical compounds

• The acute toxicology of three ether intermediates encountered in the synthesis of CR from 1-chloro-2-nitrobenzene and sodium phenoxide (2-nitrodiphenyl ether, 2-aminodiphenyl ether and 2-formamidodiphenyl ether) was investigated; all three ethers were found to be less acutely toxic than CR itself [15].

Gene context of Chloro-o-nitrobenzene

• Determination of strain CNB-1 populations by cultivation method and by quantitative competitive PCR technique targeting the chloronitrobenzene nitroreductase gene showed that the population of strain CNB-1 in the rhizosphere was about 10-100 times higher than that in the bulk soil [16].

Analytical, diagnostic and therapeutic context of Chloro-o-nitrobenzene

• A single microorganism able to mineralize chloronitrobenzenes (CNBs) has not been reported, and degradation of CNBs by coculture of two microbial strains was attempted [1].
• The structure of the unusual anthelmintic pyrrolobenzoxazine terpenoid natural product CJ-12662 was established by X-ray crystallography and partial synthesis from 2-chloronitrobenzene [17].
• We compare computer simulations to experimental scanning tunneling microscopy (STM) images of chloronitrobenzene molecules on a Cu(111) surface [18].

References