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Chemical Compound Review

BEHA     bis(2-ethylhexyl) hexanedioate

Synonyms: DEHA, Mollan S, Effomoll DA, Vestinol OA, Lankroflex DOA, ...
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Disease relevance of Rucoflex plasticizer doa


High impact information on Rucoflex plasticizer doa


Biological context of Rucoflex plasticizer doa


Anatomical context of Rucoflex plasticizer doa

  • With both DEHA preparations, during the first 24 hr after administration high levels of radioactivity were observed particularly in the body fat, liver and kidneys (after iv and ig administration) and in the intestinal contents (after ig administration) of both species [7].

Associations of Rucoflex plasticizer doa with other chemical compounds


Gene context of Rucoflex plasticizer doa


Analytical, diagnostic and therapeutic context of Rucoflex plasticizer doa


  1. Di(2-ethylhexyl) adipate (DEHA) induced developmental toxicity but not antiandrogenic effects in pre- and postnatally exposed Wistar rats. Dalgaard, M., Hass, U., Vinggaard, A.M., Jarfelt, K., Lam, H.R., Sørensen, I.K., Sommer, H.M., Ladefoged, O. Reprod. Toxicol. (2003) [Pubmed]
  2. Identification of the proximate peroxisome proliferator(s) derived from di (2-ethylhexyl) adipate and species differences in response. Cornu, M.C., Lhuguenot, J.C., Brady, A.M., Moore, R., Elcombe, C.R. Biochem. Pharmacol. (1992) [Pubmed]
  3. Microsomal lauric acid hydroxylase activities after treatment of rats with three classical cytochrome P450 inducers and peroxisome proliferating compounds. Dirven, H.A., van den Broek, P.H., Peters, J.G., Noordhoek, J., Jongeneelen, F.J. Biochem. Pharmacol. (1992) [Pubmed]
  4. Determination of adipate plasticizers in poly(vinyl chloride) by microwave-assisted extraction. Cano, J.M., Marín, M.L., Sánchez, A., Hernandis, V. Journal of chromatography. A. (2002) [Pubmed]
  5. Determination of phthalate esters in water samples by solid-phase microextraction and gas chromatography with mass spectrometric detection. Peñalver, A., Pocurull, E., Borrull, F., Marcé, R.M. Journal of chromatography. A. (2000) [Pubmed]
  6. Effect of the plasticizer di(2-ethylhexyl) adipate (dioctyladipate, DOA) on lipid metabolism in the rat: I. Inhibition of cholesterolgenesis and modification of phospholipid synthesis. Bell, F.P. Lipids (1983) [Pubmed]
  7. Di-(2-ethylhexyl)adipate: absorption, autoradiographic distribution and elimination in mice and rats. Bergman, K., Albanus, L. Food Chem. Toxicol. (1987) [Pubmed]
  8. Significant increase of 8-hydroxydeoxyguanosine in liver DNA of rats following short-term exposure to the peroxisome proliferators di(2-ethylhexyl)phthalate and di(2-ethylhexyl)adipate. Takagi, A., Sai, K., Umemura, T., Hasegawa, R., Kurokawa, Y. Jpn. J. Cancer Res. (1990) [Pubmed]
  9. Genotoxic effects of selected peroxisome proliferators. Reisenbichler, H., Eckl, P.M. Mutat. Res. (1993) [Pubmed]
  10. Peroxisome proliferation due to di (2-ethylhexyl) adipate, 2-ethylhexanol and 2-ethylhexanoic acid. Keith, Y., Cornu, M.C., Canning, P.M., Foster, J., Lhuguenot, J.C., Elcombe, C.R. Arch. Toxicol. (1992) [Pubmed]
  11. Metabolites from the biodegradation of di-ester plasticizers by Rhodococcus rhodochrous. Nalli, S., Cooper, D.G., Nicell, J.A. Sci. Total Environ. (2006) [Pubmed]
  12. Subacute oral toxicity study of di(2-ethylhexyl)adipate based on the draft protocol for the "Enhanced OECD Test Guideline no. 407". Miyata, K., Shiraishi, K., Houshuyama, S., Imatanaka, N., Umano, T., Minobe, Y., Yamasaki, K. Arch. Toxicol. (2006) [Pubmed]
  13. Specific migration of di-(2-ethylhexyl)adipate (DEHA) from plasticized PVC film: results from an enforcement campaign. Petersen, J.H., Breindahl, T. Food additives and contaminants. (1998) [Pubmed]
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