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Chemical Compound Review

CCG-37762     propane-1-sulfonic acid

Synonyms: NSC-87882, AC1L2WAD, NCI87882, NSC87882, CTK1A3677, ...
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Disease relevance of Propanesulfonic acid


High impact information on Propanesulfonic acid

  • Using methyl-beta-N-acetylglucosaminide as a substrate, the optimal activity was obtained with 0.1% Triton X-100, 30 mM NaF, 20 mM Mn2+, 5 mM AMP in a 30 mM MOPS (3-(N-morpholino) propanesulfonic acid) buffer at pH 6 [2].
  • We have investigated the functioning of monogalactosyldiacylglycerol (MGDG) synthase activity partially purified from spinach chloroplast envelope membranes, using mixed micelles containing diacylglycerol (the substrate for MGDG synthase), CHAPS (3-[(cholamidopropyl)dimethylammonio]-1- propanesulfonic acid), and phosphatidylglycerol [3].
  • When intact kidney mitochondria were added to isotonic 3'-(N'-morpholino) propanesulfonic acid buffer with 25 mM KHCO3 (1% labeled with 18O) the rate of disappearance of C18O16O was biphasic; this indicates that there is carbonic anhydrase within the inner mitochondrial membrane [4].
  • The following conditions had no effect on the metabolic activity of C. glutamicum: a carbon starvation of up to 19 h, anaerobic conditions, lactic acid concentrations up to 10 g/l, 3-(N-morpholino) propanesulfonic acid buffer concentrations up to 42 g/l, or pH from 6.4 to 7 [5].
  • RESULTS: The optimum pH of this method was 7.8, and 3-[4-(2-hydroxyethyl)-1-piperazinyl] propanesulfonic acid (EPPS) buffer solution was selected [6].

Associations of Propanesulfonic acid with other chemical compounds


Gene context of Propanesulfonic acid

  • After homogenization, squeezing of shrimp samples and protein precipitation, a two-step-SPE-clean up was performed using a C18-cartridge and a propylsulfonic acid cation-exchange SPE followed by HPLC analysis with electrochemical detection (750 mV) [8].
  • The detergent 3-(4-heptyl)phenyl 3-hydroxypropyl dimethylammonio propanesulfonate (C7BzO), which favors the solubilization of proteins, but which interferes with SDS equilibration and second dimension PAGE, was effectively removed by ultrafiltration and exchanged with CHAPS without measurable loss of protein [9].

Analytical, diagnostic and therapeutic context of Propanesulfonic acid

  • In rapid chemical quench experiments, the propylsulfonate ligand was identified by NMR spectroscopy and high performance liquid chromatography as propanesulfonic acid after protonolysis of the MCR(PS) complex [10].
  • SL vesicles were solubilized with 3-[(3-cholamidopropyl)dimethylammonio]-1- propanesulfonate and subjected to IAA-Sepharose affinity chromatography [11].
  • [14C]Penicillin G-labeled PBP 1Bper eluted from a gel filtration column in the presence but not in the absence of 0.7% 3-[(3-cholamidopropyl)dimethylammonio]-1- propanesulfonic acid, and PBP 1Bper was found entirely in the membrane fraction of a thrombin digest of membranes containing overproduced PBP 1B-GT/H6 [12].
  • An assay for sperm antibodies using a live sperm ELISA has been developed to detect sperm surface antigens and used to validate an assay using a 3-[(3-cholamidopropyl) dimethylammonio]-1 propanesulfonate (CHAPS) membrane extract of whole tammar wallaby sperm [13].


  1. Mercury kinetics in a case of severe mercuric chloride poisoning treated with dimercapto-1-propane sulphonate (DMPS). Toet, A.E., van Dijk, A., Savelkoul, T.J., Meulenbelt, J. Human & experimental toxicology. (1994) [Pubmed]
  2. Characterization of an N-acetylglucosamine-6-O-sulfotransferase from human respiratory mucosa active on mucin carbohydrate chains. Degroote, S., Lo-Guidice, J.M., Strecker, G., Ducourouble, M.P., Roussel, P., Lamblin, G. J. Biol. Chem. (1997) [Pubmed]
  3. Kinetic properties of monogalactosyldiacylglycerol synthase from spinach chloroplast envelope membranes. Maréchal, E., Block, M.A., Joyard, J., Douce, R. J. Biol. Chem. (1994) [Pubmed]
  4. Rat kidney mitochondrial carbonic anhydrase. Dodgson, S.J., Contino, L.C. Arch. Biochem. Biophys. (1988) [Pubmed]
  5. Metabolic activity of Corynebacterium glutamicum grown on L: -lactic acid under stress. Seletzky, J.M., Noack, U., Fricke, J., Hahn, S., B??chs, J. Appl. Microbiol. Biotechnol. (2006) [Pubmed]
  6. Development and application of serum cholinesterase activity measurement using benzoylthiocholine iodide. Osawa, S., Kariyone, K., Ichihara, F., Arai, K., Takagasa, N., Ito, H. Clin. Chim. Acta (2005) [Pubmed]
  7. Determination of malachite green and its metabolite, leucomalachite green, in catfish (Ictalurus punctatus) tissue by liquid chromatography with visible detection. Roybal, J.E., Pfenning, A.P., Munns, R.K., Holland, D.C., Hurlbut, J.A., Long, A.R. Journal of AOAC International. (1995) [Pubmed]
  8. Suitability of tryptophan radiation products as markers for the detection of gamma-irradiated protein rich food. Kleeberg, K.K., Müller, A., Simat, T.J., Steinhart, H. Adv. Exp. Med. Biol. (2003) [Pubmed]
  9. Simultaneous reduction and alkylation of protein disulfides in a centrifugal ultrafiltration device prior to two-dimensional gel electrophoresis. Smejkal, G.B., Li, C., Robinson, M.H., Lazarev, A.V., Lawrence, N.P., Chernokalskaya, E. J. Proteome Res. (2006) [Pubmed]
  10. Spectroscopic and Kinetic Studies of the Reaction of Bromopropanesulfonate with Methyl-coenzyme M Reductase. Kunz, R.C., Horng, Y.C., Ragsdale, S.W. J. Biol. Chem. (2006) [Pubmed]
  11. Indanyloxyacetic acid-sensitive chloride channels from outer membranes of skeletal muscle. Weber-Schürholz, S., Wischmeyer, E., Laurien, M., Jockusch, H., Schürholz, T., Landry, D.W., al-Awqati, Q. J. Biol. Chem. (1993) [Pubmed]
  12. Penicillin-binding protein 1B from Escherichia coli contains a membrane association site in addition to its transmembrane anchor. Nicholas, R.A., Lamson, D.R., Schultz, D.E. J. Biol. Chem. (1993) [Pubmed]
  13. Immune response of the tammar wallaby (Macropus eugenii) to sperm antigens. Kay, D.J., Kitchener, A.L. Reprod. Fertil. Dev. (2004) [Pubmed]
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