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Chemical Compound Review

Amietol M 11     2-methylaminoethanol

Synonyms: CHEMBL104083, ACMC-1BPVV, CCRIS 4845, LS-489, AG-D-58190, ...
 
 
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Disease relevance of Usaf do-50

 

High impact information on Usaf do-50

  • Hepatocytes were treated with 400 microM monomethylethanolamine overnight, which resulted in an increase in the cellular content of the derived phospholipid, phosphatidylmonomethylethanolamine, from 0.32 +/- 0.15 to 2.92 +/- 0.74 nmol/mg of cell protein [5].
  • Moreover, the pool of apoprotein B present in intact microsomes from hepatocytes incubated with monomethylethanolamine was more accessible to exogenously added trypsin, presumably because a larger pool of the apoprotein B was exposed on the cytosolic surface of these microsomes [5].
  • Since ethanolamine is a product of PLD, we hypothesised that an administration of an analogue of ethanolamine, N-methylethanolamine (MEA), decreases PLD activity through a negative feedback mechanism, suppresses collagen accumulation, and thus prevents organ dysfunction [1].
  • Although MME failed to effectively inhibit either reaction, an unexpected enhancement of choline kinase activity was observed specifically with the GmCK1-encoded enzyme [6].
  • Secretion of VLDL, but not HDL, by rat hepatocytes is inhibited by the ethanolamine analogue N-monomethylethanolamine [7].
 

Biological context of Usaf do-50

 

Anatomical context of Usaf do-50

 

Associations of Usaf do-50 with other chemical compounds

 

Gene context of Usaf do-50

  • However, most of the newly synthesized IgG1 was not secreted by monomethylethanolamine-supplemented cells, even after 5 h; it remained within the cells [15].
  • Supplementation of the medium with monomethylethanolamine resulted in a 2-fold increase in labeled GPC, with a concomitant decrease of [3H]lysoPC by approx. 25% [16].

References

  1. N-methylethanolamine attenuates cardiac fibrosis and improves diastolic function: inhibition of phospholipase D as a possible mechanism. Yamamoto, K., Takahashi, Y., Mano, T., Sakata, Y., Nishikawa, N., Yoshida, J., Oishi, Y., Hori, M., Miwa, T., Inoue, S., Masuyama, T. Eur. Heart J. (2004) [Pubmed]
  2. The skin sensitization potential of four alkylalkanolamines. Leung, H.W., Blaszcak, D.L. Veterinary and human toxicology. (1998) [Pubmed]
  3. Behavior of vesicular stomatitis virus glycoprotein in mouse LM cells with modified membrane-phospholipids. Maeda, M., Doi, O., Akamatsu, Y. Biochim. Biophys. Acta (1980) [Pubmed]
  4. Acute toxicity and primary irritancy of alkylalkanolamines. Ballantyne, B., Leung, H.W. Veterinary and human toxicology. (1996) [Pubmed]
  5. Movement of apolipoprotein B into the lumen of microsomes from hepatocytes is disrupted in membranes enriched in phosphatidylmonomethylethanolamine. Rusiñol, A.E., Chan, E.Y., Vance, J.E. J. Biol. Chem. (1993) [Pubmed]
  6. Characterization of soybean choline kinase cDNAs and their expression in yeast and Escherichia coli. Monks, D.E., Goode, J.H., Dewey, R.E. Plant Physiol. (1996) [Pubmed]
  7. Secretion of VLDL, but not HDL, by rat hepatocytes is inhibited by the ethanolamine analogue N-monomethylethanolamine. Vance, J.E. J. Lipid Res. (1991) [Pubmed]
  8. Molecular cloning of the yeast OPI3 gene as a high copy number suppressor of the cho2 mutation. Preitschopf, W., Lückl, H., Summers, E., Henry, S.A., Paltauf, F., Kohlwein, S.D. Curr. Genet. (1993) [Pubmed]
  9. Regulation of phosphatidylcholine biosynthesis by the methylation pathway in rat pituitary gland. Prasad, C., Edwards, R.M. Horm. Metab. Res. (1984) [Pubmed]
  10. Physiological studies on the pneumococcal Forssman antigen: a choline-containing lipoteichoic acid. Briles, E.B., Tomasz, A. J. Gen. Microbiol. (1975) [Pubmed]
  11. Development of metastatic tumors in athymic (nude) mice from LM cells grown in vitro. Kier, A.B., Schroeder, F. Transplantation (1982) [Pubmed]
  12. Modification of phospholipid polar head group with monomethylethanolamine and dimethylethanolamine decreases cholesteryl ester and triacylglycerol synthesis in cultured human fibroblasts. Maziere, C., Auclair, M., Mora, L., Maziere, J.C. Lipids (1990) [Pubmed]
  13. Lipid composition and physical properties of membranes from C-6 glial cells with altered phospholipid polar headgroups. McKenzie, R.C., Brophy, P.J. Biochim. Biophys. Acta (1984) [Pubmed]
  14. Binding of [3H]flunitrazepam to the LM cell, a transformed murine fibroblast. Feller, D.J., Schroeder, F., Bylund, D.B. Biochem. Pharmacol. (1983) [Pubmed]
  15. Phospholipid modification retards intracellular transport and secretion of immunoglobulin G1 by mouse MOPC-31c plasmacytoma cells. Nakano, A., Maeda, M., Nishijima, M., Akamatsu, Y. Biochim. Biophys. Acta (1982) [Pubmed]
  16. Head group specificity in the regulation of phosphatidylcholine catabolism in rat hepatocytes. Tijburg, L.B., Vance, D.E. Biochim. Biophys. Acta (1991) [Pubmed]
 
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