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MeSH Review

Single-Blind Method

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Disease relevance of Single-Blind Method


Psychiatry related information on Single-Blind Method


High impact information on Single-Blind Method


Chemical compound and disease context of Single-Blind Method


Biological context of Single-Blind Method


Anatomical context of Single-Blind Method


Associations of Single-Blind Method with chemical compounds


Gene context of Single-Blind Method

  • METHOD: This randomized, crossover, single-blind study compared osmotic, controlled-release oral system (OROS) MPH (Concerta) given q.d. to immediate-release MPH (Ritalin) given in equal doses t.i.d. on driving performance among six male ADHD-diagnosed adolescent drivers aged 16 to 19 years [35].
  • In a small, single blind study, we found that OT almost doubled sperm retrieval when compared with vehicle administration [36].
  • We conducted a retrospective single-blind study assessing the value of MRI in 44 children surgically treated for partial epilepsy, and correlated the MRI findings with the pathology in all cases [37].
  • In a pilot single-blind study, gamma-vinyl GABA, an enzyme-activated irreversible inhibitor of GABA-transaminase (GABA-T), was administered orally to 10 epileptic patients who were refractory to conventional anticonvulsant therapy [38].
  • The relative chronotropic and inotropic activity of preferential beta 1- and beta 2-adrenoceptor stimulation was investigated in seven healthy male subjects in a randomized within-subject, single-blind study [39].

Analytical, diagnostic and therapeutic context of Single-Blind Method


  1. Treatment of postmenopausal osteoporosis with calcitriol or calcium. Tilyard, M.W., Spears, G.F., Thomson, J., Dovey, S. N. Engl. J. Med. (1992) [Pubmed]
  2. Comparison of sucralfate and ranitidine in the treatment of duodenal ulcers. Garcia-Paredes, J., Diaz Rubio, M., Llenas, F., Taxonera, C., Pardo, L. Am. J. Med. (1991) [Pubmed]
  3. Haemodynamic effects of diltiazem at rest and during exercise in patients with previous myocardial infarction. Cobelli, F., Opasich, C., Riccardi, G., Rossetti, S., Guffanti, E., Specchia, G. Eur. Heart J. (1987) [Pubmed]
  4. Assessment of the efficacy and safety of nimesulide vs naproxen in paediatric patients with respiratory tract infections. A comparative single-blind study. Salmòn Rodriguez, L.E., Arista Viveros, H.A., Lujan, M.E., Maciel, R.M., Trujillo, C.L., Lopez, E. Drugs (1993) [Pubmed]
  5. Comparative efficacy of SSRIs and amisulpride in burning mouth syndrome: a single-blind study. Maina, G., Vitalucci, A., Gandolfo, S., Bogetto, F. The Journal of clinical psychiatry. (2002) [Pubmed]
  6. Intramuscular desferrioxamine in patients with Alzheimer's disease. Crapper McLachlan, D.R., Dalton, A.J., Kruck, T.P., Bell, M.Y., Smith, W.L., Kalow, W., Andrews, D.F. Lancet (1991) [Pubmed]
  7. Effect of tyrosine on attention deficit disorder with hyperactivity. Eisenberg, J., Asnis, G.M., van Praag, H.M., Vela, R.M. The Journal of clinical psychiatry. (1988) [Pubmed]
  8. Efficacy of fluvoxamine, paroxetine, and citalopram in the treatment of obsessive-compulsive disorder: a single-blind study. Mundo, E., Bianchi, L., Bellodi, L. Journal of clinical psychopharmacology. (1997) [Pubmed]
  9. Topiramate versus bupropion SR when added to mood stabilizer therapy for the depressive phase of bipolar disorder: a preliminary single-blind study. McIntyre, R.S., Mancini, D.A., McCann, S., Srinivasan, J., Sagman, D., Kennedy, S.H. Bipolar disorders. (2002) [Pubmed]
  10. Genetic determinants of responsiveness to the HMG-CoA reductase inhibitor fluvastatin in patients with molecularly defined heterozygous familial hypercholesterolemia. Leitersdorf, E., Eisenberg, S., Eliav, O., Friedlander, Y., Berkman, N., Dann, E.J., Landsberger, D., Sehayek, E., Meiner, V., Wurm, M. Circulation (1993) [Pubmed]
  11. Effect of clinical doses of fluoxetine on psychological variables in healthy volunteers. Gelfin, Y., Gorfine, M., Lerer, B. The American journal of psychiatry. (1998) [Pubmed]
  12. Single-blind comparative study of nabumetone (Relafen) versus naproxen in the treatment of rheumatoid arthritis. Hazleman, B.L., Thomas, P.P. Am. J. Med. (1987) [Pubmed]
  13. Endoscopic studies of nabumetone in patients with rheumatoid arthritis. A comparative endoscopic and histologic evaluation. Greb, W.H., von Schrader, H.W., Cerlek, S., Dominis, M., Hauptmann, E., Zenić, N. Am. J. Med. (1987) [Pubmed]
  14. Neuroendocrine effects of buspirone in patients with generalized anxiety disorder. Cohn, J.B., Wilcox, C.S., Meltzer, H.Y. Am. J. Med. (1986) [Pubmed]
  15. Effect of celiprolol treatment in hypertensive patients with sleep apnea. Planès, C., Foucher, A., Leroy, M., Dartois, N., Juste, K., Baillart, O., Raffestin, B. Sleep. (1999) [Pubmed]
  16. A single-blind study of the efficacy and safety of intravenous granisetron compared with alizapride plus dexamethasone in the prophylaxis and control of emesis in patients receiving 5-day cytostatic therapy. The Granisetron Study Group. Bremer, K. Eur. J. Cancer (1992) [Pubmed]
  17. A single-blind comparison of three-day azithromycin and ten-day co-amoxiclav treatment of acute lower respiratory tract infections. Hoepelman, A.I., Sips, A.P., van Helmond, J.L., van Barneveld, P.W., Neve, A.J., Zwinkels, M., Rozenberg-Arska, M., Verhoef, J. J. Antimicrob. Chemother. (1993) [Pubmed]
  18. Effect of surgical cleaning of the skin on the pathergy phenomenon in Behçet's syndrome. Fresko, I., Yazici, H., Bayramiçli, M., Yurdakul, S., Mat, C. Ann. Rheum. Dis. (1993) [Pubmed]
  19. Treatment of chlamydial conjunctivitis in newborns and adults with erythromycin and roxithromycin. Stenberg, K., Mårdh, P.A. J. Antimicrob. Chemother. (1991) [Pubmed]
  20. Finasteride, a steroid 5 alpha-reductase inhibitor, does not affect the oxidative metabolism of antipyrine. Winchell, G.A., Gregoire, S., Taylor, A.M., Hegland, J., Hunninghake, D.B. Journal of clinical pharmacology. (1993) [Pubmed]
  21. Metabolic effects of atenolol and doxazosin in healthy volunteers during prolonged physical exercise. Cosenzi, A., Sacerdote, A., Bocin, E., Molino, R., Mangiarotti, M., Bellini, G. J. Cardiovasc. Pharmacol. (1995) [Pubmed]
  22. A single blind study of naftidrofuryl in the treatment of peripheral vascular disorders in general practice. Clyne, M.B., Lask, A. The British journal of clinical practice. (1978) [Pubmed]
  23. Effect of pipecuronium and pancuronium on intracranial pressure and cardiovascular parameters in patients with supratentorial tumours. Shaheen, B., Wig, J., Grewal, S., Tewari, M.K. Neurology India. (2000) [Pubmed]
  24. Dexamethasone isonicotinate inhibits dual and late asthmatic reactions but not the increase of airway responsiveness induced by toluene diisocyanate in sensitized subjects. Tossin, L., Corona, P.C., Leproux, G.B., De Marzo, N., Crescioli, S., Fabbri, L.M., Mapp, C.E. Annals of allergy. (1989) [Pubmed]
  25. Intravenous nizatidine kinetics and acid suppression. Callaghan, J.T., Bergstrom, R.F., Obermeyer, B.D., King, E.P., Offen, W.W. Clin. Pharmacol. Ther. (1985) [Pubmed]
  26. Efficacy and tolerability of the switch from a branded to a generic warfarin sodium product: an observer-blinded, randomized, crossover study. Lee, H.L., Kan, C.D., Yang, Y.J. Clinical therapeutics. (2005) [Pubmed]
  27. Infectious complications after 809 biliary tract operations and results of a prospective randomized single-blind study comparing cefoxitin versus ampicillin plus an inhibitor of beta-lactamases. Wittmann, D.H., Koltowski, P., Oleszkiewicz, J., Walker, A.P. Infection (1990) [Pubmed]
  28. Comparative haemodynamic effects of nicardipine and verapamil in coronary artery disease. Silke, B., Verma, S.P., Hussain, M., Jackson, N.C., Hafizullah, M., Reynolds, G., Taylor, S.H. Herz. (1985) [Pubmed]
  29. Lateralization of epileptic foci by magnetic resonance imaging in temporal lobe epilepsy. Kuzniecky, R., Suggs, S., Gaudier, J., Faught, E. Journal of neuroimaging : official journal of the American Society of Neuroimaging. (1991) [Pubmed]
  30. Serum concentrations and effects of (+/-)-nicardipine compared with nifedipine in a population of healthy subjects. Porchet, H.C., Dayer, P. Clin. Pharmacol. Ther. (1990) [Pubmed]
  31. Yohimbine augmentation of fluvoxamine in refractory depression: a single-blind study. Cappiello, A., McDougle, C.J., Malison, R.T., Heninger, G.R., Price, L.H. Biol. Psychiatry (1995) [Pubmed]
  32. Salt and blood pressure responses to calcium antagonism in hypertensive patients. Weir, M.R., Hall, P.S., Behrens, M.T., Flack, J.M. Hypertension (1997) [Pubmed]
  33. Quantitative gastroesophageal reflux and pulmonary function in asthmatic children and normal adults receiving placebo, theophylline, and metaproterenol sulfate therapy. Berquist, W.E., Rachelefsky, G.S., Rowshan, N., Siegel, S., Katz, R., Welch, M. J. Allergy Clin. Immunol. (1984) [Pubmed]
  34. Poylmerized whole ragweed: an improved method of immunotherapy. Bacal, E., Zeiss, C.R., Suszko, I., Levitz, D., Patterson, R. J. Allergy Clin. Immunol. (1978) [Pubmed]
  35. Impact of methylphenidate delivery profiles on driving performance of adolescents with attention-deficit/hyperactivity disorder: a pilot study. Cox, D.J., Merkel, R.L., Penberthy, J.K., Kovatchev, B., Hankin, C.S. Journal of the American Academy of Child and Adolescent Psychiatry. (2004) [Pubmed]
  36. Identification, localization and functional activity of oxytocin receptors in epididymis. Filippi, S., Vannelli, G.B., Granchi, S., Luconi, M., Crescioli, C., Mancina, R., Natali, A., Brocchi, S., Vignozzi, L., Bencini, E., Noci, I., Ledda, F., Forti, G., Maggi, M. Mol. Cell. Endocrinol. (2002) [Pubmed]
  37. Magnetic resonance imaging in childhood intractable partial epilepsies: pathologic correlations. Kuzniecky, R., Murro, A., King, D., Morawetz, R., Smith, J., Powers, R., Yaghmai, F., Faught, E., Gallagher, B., Snead, O.C. Neurology (1993) [Pubmed]
  38. Biochemical and clinical effects of gamma-vinyl GABA in patients with epilepsy. Schechter, P.J., Hanke, N.F., Grove, J., Huebert, N., Sjoerdsma, A. Neurology (1984) [Pubmed]
  39. Noninvasive assessment of chronotropic and inotropic response to preferential beta-1 and beta-2 adrenoceptor stimulation. Corea, L., Bentivoglio, M., Verdecchia, P., Motolese, M., Sorbini, C.A., Grassi, V., Tantucci, C. Clin. Pharmacol. Ther. (1984) [Pubmed]
  40. Effects of trazodone on EEG sleep and clinical state in major depression. van Bemmel, A.L., Havermans, R.G., van Diest, R. Psychopharmacology (Berl.) (1992) [Pubmed]
  41. Unexpectedly high rate of phlebographic deep venous thrombosis following elective general abdominal surgery among patients given prophylaxis with low-molecular-weight heparin. Bounameaux, H., Huber, O., Khabiri, E., Schneider, P.A., Didier, D., Rohner, A. Archives of surgery (Chicago, Ill. : 1960) (1993) [Pubmed]
  42. Changes in calcium homoeostasis in patients undergoing liver transplantation: effects of a single infusion of pamidronate administered pre-operatively. Bishop, N.J., Ninkovic, M., Alexander, G.J., Holmes, S.D., Milligan, T., Price, C., Compston, J.E. Clin. Sci. (1999) [Pubmed]
  43. Comparative effects of theophylline and isosorbide dinitrate on exercise capacity in stable angina pectoris, and their mechanisms of action. Crea, F., Pupita, G., Galassi, A.R., el-Tamimi, H., Kaski, J.C., Davies, G.J., Maseri, A. Am. J. Cardiol. (1989) [Pubmed]
  44. Hemodialysis-related nodulocystic acne treated with isotretinoin. Lin, J., Shih, I., Yu, C. Nephron (1999) [Pubmed]
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