Disease relevance of heptan-2-one

• Inhalation toxicity of methyl n-amyl ketone (2-heptanone) in rats and monkeys [1].

High impact information on heptan-2-one

• Six components, whose concentrations were depressed after adrenalectomy, were identified: 2-heptanone, trans-5-hepten-2-one, trans-4-hepten-2-one, n-pentyl acetate, cis-2-penten-1-yl acetate, and 2,5-dimethylpyrazine [2].
• Significantly fewer eag antennal neurons responded to EB compared with control neurons; the proportion sensitive to 2-heptanone was similar to controls [3].
• In this study w/o-microemulsions were used to investigate the kinetics of the reduction of 2-Heptanone to S-2-Heptanol, catalyzed by alcohol dehydrogenase [4].
• Whereas permeability of 2-nonanone through WG coated paper was not affected by the concentration differential, a high concentration of 2-heptanone induced a permeability increase, which can be explained by a slight plasticization effect of this compound [5].
• Aspergillus sp. correlated with heptan-2-one, hexan-2-one, octan-3-ol, octan-3-one, and alpha-terpineol, while the occurrence of Eurotium sp. was correlated with higher indoor air concentrations of 3-methylbutan-1-ol, 3-methylbutan-2-ol, heptan-2-one, hexan-2-one, octan-3-ol, and thujopsene [6].

Biological context of heptan-2-one

• 2. The amount of label recovered in 14CO2 matched the amount of unlabelled 2-heptanone plus 4-heptanone recovered from urine, suggesting that both types of metabolite may have been derived form the major urinary metabolite, 2-ethylhexanoic acid, by decarboxylation following partial beta-oxidation [7].

Anatomical context of heptan-2-one

• Regarding aliphatic monoketone compounds, acetone, 2-pentanone, 2-heptanone, and 2-octanone were confirmed non-neurotoxic for the peripheral nervous system [8].
• Furthermore, adenylyl cyclase activity in membranes prepared from the MOE of wild-type mice, but not AC3-/- mice, is stimulated by 2-heptanone, a mouse pheromone [9].

Associations of heptan-2-one with other chemical compounds

• Metabolism of methyl n-amyl ketone (2-heptanone) and its binding to DNA of rat liver in vivo and in vitro [10].
• Partition coefficients were calculated during 2-heptanone reduction to 2-heptanol by Saccharomyces cerevisiae [11].

Gene context of heptan-2-one

• Sensory characteristics of 2-heptanone. Part I. Threshold values, concentration/odour intensity relations, methodological aspects [12].

Analytical, diagnostic and therapeutic context of heptan-2-one

• The evaluation of threshold values and concentration/odour intensity relations for 2-heptanone has been carried out in two laboratories applying strictly uniform materials, methods and laboratory procedures [12].

References