Disease relevance of Dimethylallyladenine

• Cytokinins such as isopentenyladenine (IPA) and kinetin are very effective at inducing the granulocytic differentiation of human myeloid leukemia HL-60 cells [1].
• Interactions of N6-(delta2-isopentenyl)adenine with cyclic AMP on the regulation of growth and beta-galactosidase synthesis in Escherichia coli [2].

High impact information on Dimethylallyladenine

• In addition, isopentenyladenine, like mevalonate, stimulated DNA synthesis specifically during the S phase of the cell cycle [3].
• Liquid chromatography-mass spectrometry analysis demonstrated that the prenyl group of trans-zeatin (tZ) and isopentenyladenine is mainly produced through the MEP pathway [4].
• Although hydroxylation of isopentenyladenine-type CKs is a key step of tZ biosynthesis, the catalyzing enzyme has not been characterized yet [5].
• The first step of de novo synthesis of CKs is catalyzed by adenosine phosphate-isopentenyltransferase (IPT), which produces isopentenyladenine nucleotide [6].
• Overexpression of FPS in mitochondria also led to altered leaf cytokinin profile, with a reduction in the contents of physiologically active trans-zeatin- and isopentenyladenine-type cytokinins and their corresponding riboside monophosphates as well as enhanced levels of cis-zeatin 7-glucoside and storage cytokinin O-glucosides [7].

Biological context of Dimethylallyladenine

• Changes in iP + iPR contents in the roots were not significantly correlated with those in the endosperms and the cell division rate [8].
• These results suggest that among the cytokinins the species that can regulate the electron transport is iP rather than its riboside or zeatin [9].
• The levels of zeatin ryboside ([9R]Z) and benzyladenosine ([9R]BAP) were predominant and isopentenyladenine (iP) was very low for the cells E of both genotypes [10].

Anatomical context of Dimethylallyladenine

• It was found that, in both the leaf tissues and leaf exudate, isopentenyladenine forms of cytokinins increased from 16 h after the start of the long day [11].

Associations of Dimethylallyladenine with other chemical compounds

• Multiple modes of ligand recognition: crystal structures of cyclin-dependent protein kinase 2 in complex with ATP and two inhibitors, olomoucine and isopentenyladenine [12].
• This study reports the effects of thidiazuron (TDZ) on the endogenous levels of indoleacetic acid (IAA), zeatin, zeatin riboside ([9R]Z), isopentenyladenine and isopentenyladenosine ([9R]iP) as well as structural changes in the apical meristem of Dendrobium Second Love shoots during flower induction and initial development in vitro [13].
• This article presents a molecular dynamics (MD) study of the cdk2 enzyme and its two complexes with the inhibitors isopentenyladenine and roscovitine using the Cornell et al. force field from the AMBER software package [14].

Gene context of Dimethylallyladenine

• In the CDK2/isopentenyladenine complex simulation, two water molecules that arrange interaction between the inhibitor and the enzyme via an H-bond were observed [15].
• In this article five structures of human CDK2 are summarised: apoprotein, ATP complex, olomoucine complex, isopentenyladenine complex, and des-chloro-flavopiridol complex [16].

References