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Chemical Compound Review:

Farnesoic acid 3,7,11-trimethyldodeca- 2,6,10-trienoic acid

Synonyms: AGN-PC-00PO4A, AG-F-59246, AG-H-00800, AC1L3PED, CTK1D1994, ...

Mak, A.S. et al., Gadot, M. et al., Moshitzky, P. et al., Tobe, S.S. et al., Saunders, D.S. et al., et al.

Chan, Mak, Choi, Ma, Hui, Tiu,

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High impact information on Farnesoic acid

Furthermore, DSF is structurally and functionally related to farnesoic acid (FA), which regulates morphological transition and virulence by Candida albicans, a fungal pathogen [1].
Vitellogenesis in the red crab Charybdis feriatus: Hepatopancreas-specific expression and farnesoic acid stimulation of vitellogenin gene expression [2].
Stimulation of JH biosynthesis by the corpora allata of adult female Aedes aegypti in vitro: effect of farnesoic acid and Aedes allatotropin [3].
Farnesoic acid O-methyltransferase (FAMeT) catalyzes the methylation of farnesoic acid (FA) to produce MF in the terminal step of MF synthesis [4].
Allatal maturation during the first gonotrophic cycle of adult female Locusta migratoria can be measured in vitro by the competence of these glands to produce juvenile hormone III (JH-III) when maximally stimulated by either farnesoic acid (FA) or allatotropin [5].

Biological context of Farnesoic acid

2. Parallel observations on glands incubated with farnesenic acid show that the rate-limiting step is always prior to the stage of esterification of farnesenic acid to the final intermediate, methyl farnesoate [6].
Vitellogenesis in the Red Crab, Charybdis feriatus: Contributions from Small Vitellogenin Transcripts (CfVg) and Farnesoic Acid Stimulation of CfVg Expression [7].
Competitive binding studies showed that this binding was specific for MF, with farnesoic acid and JH homologues having less than 30 and 7%, respectively, of the relative binding activity of MF [8].

Anatomical context of Farnesoic acid

Using a short term in vitro hepatopancreas explant culture assay, we have demonstrated that low concentrations of farnesoic acid (FA) stimulate CfVg gene expression in the hepatopancreas [2].
The inhibition effects of farnesol, farnesoic acid, and farnesol derivatives on the atRA metabolism were evaluated in microsome and in AMC-HN-6 cells [9].

Associations of Farnesoic acid with other chemical compounds

Mevinolin, an inhibitor of the mevalonate pathway, significantly reduces the biosynthesis of JHB(3), while farnesoic acid, a proximate precursor of JHIII, significantly stimulates the biosynthesis of both JHB(3) and JHIII in vitro [10].

Gene context of Farnesoic acid

Corpora allata incubated in medium supplemented with farnesoic acid showed an increase in the rate of JH synthesis, but the increase was relatively greater with corpora allata from nondiapausing flies [11].

Analytical, diagnostic and therapeutic context of Farnesoic acid

Comparative immunohistochemistry and cellular distribution of farnesoic acid O-methyltransferase in the shrimp and the crayfish [12].

References

A bacterial cell-cell communication signal with cross-kingdom structural analogues. Wang, L.H., He, Y., Gao, Y., Wu, J.E., Dong, Y.H., He, C., Wang, S.X., Weng, L.X., Xu, J.L., Tay, L., Fang, R.X., Zhang, L.H. Mol. Microbiol. (2004) [Pubmed]
Vitellogenesis in the red crab Charybdis feriatus: Hepatopancreas-specific expression and farnesoic acid stimulation of vitellogenin gene expression. Mak, A.S., Choi, C.L., Tiu, S.H., Hui, J.H., He, J.G., Tobe, S.S., Chan, S.M. Mol. Reprod. Dev. (2005) [Pubmed]
Stimulation of JH biosynthesis by the corpora allata of adult female Aedes aegypti in vitro: effect of farnesoic acid and Aedes allatotropin. Li, Y., Unnithan, G.C., Veenstra, J.A., Feyereisen, R., Noriega, F.G. J. Exp. Biol. (2003) [Pubmed]
Function and cellular localization of farnesoic acid O-methyltransferase (FAMeT) in the shrimp, Metapenaeus ensis. Gunawardene, Y.I., Tobe, S.S., Bendena, W.G., Chow, B.K., Yagi, K.J., Chan, S.M. Eur. J. Biochem. (2002) [Pubmed]
Farnesoic acid and allatotropin stimulation in relation to locust allatal maturation. Gadot, M., Applebaum, S.W. Mol. Cell. Endocrinol. (1986) [Pubmed]
Corpus allatum activity in vitro during ovarian maturation in the desert locust, Schistocerca gregaria. Tobe, S.S., Pratt, G.E. J. Exp. Biol. (1975) [Pubmed]
Vitellogenesis in the Red Crab, Charybdis feriatus: Contributions from Small Vitellogenin Transcripts (CfVg) and Farnesoic Acid Stimulation of CfVg Expression. Chan, S.M., Mak, A.S., Choi, C.L., Ma, T.H., Hui, J.H., Tiu, S.H. Ann. N. Y. Acad. Sci. (2005) [Pubmed]
Characterization of a methyl farnesoate binding protein in hemolymph from Libinia emarginata. Li, H., Borst, D.W. Gen. Comp. Endocrinol. (1991) [Pubmed]
Inhibition effect of new farnesol derivatives on all-trans-retinoic acid metabolism. Kim, S.Y., Kim, C., Han, I.S., Lee, S.C., Kim, S.H., Lee, K.S., Choi, Y., Byun, Y. Metab. Clin. Exp. (2001) [Pubmed]
Biosynthetic maturation of the corpus allatum of the female adult medfly, Ceratitis capitata, and its putative control. Moshitzky, P., Gilbert, L.I., Applebaum, S.W. J. Insect Physiol. (2003) [Pubmed]
Photoperiodic diapause in Drosophila melanogaster involves a block to the juvenile hormone regulation of ovarian maturation. Saunders, D.S., Richard, D.S., Applebaum, S.W., Ma, M., Gilbert, L.I. Gen. Comp. Endocrinol. (1990) [Pubmed]
Comparative immunohistochemistry and cellular distribution of farnesoic acid O-methyltransferase in the shrimp and the crayfish. Silva Gunawardene, Y.I., Bendena, W.G., Tobe, S.S., Chan, S.M. Peptides (2003) [Pubmed]

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