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Gene Review

KIF20A  -  kinesin family member 20A

Homo sapiens

Synonyms: GG10_2, Kinesin-like protein KIF20A, MKLP2, MKlp2, Mitotic kinesin-like protein 2, ...
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Disease relevance of KIF20A


High impact information on KIF20A


Biological context of KIF20A


Anatomical context of KIF20A

  • Knockdown of endogenous RAB6KIFL expression in PDAC cell lines by small interfering RNA drastically attenuated growth of those cells, suggesting an essential role for the gene product in maintaining viability of PDAC cells [1].
  • RAB6KIFL belongs to the kinesin superfamily of motor proteins, which have critical functions in trafficking of molecules and organelles [1].
  • Decreased levels of endogenous RAB6KIFL in PDAC cells altered the subcellular localization of DLG5 from cytoplasmic membranes to cytoplasm [1].
  • Since the GTP-bound form of Rab6B (Rab6B Q72L) does interact with all known Rab6A effectors, including Rabkinesin-6, the results suggest a cell-type specific role for Rab6B in retrograde membrane traffic at the level of the Golgi complex [5].
  • Here we outline biochemical assays for studying the interaction of Rabkinesin-6/Rab6-KIFL/MKlp2 with microtubules, and its regulation and interaction with the mitotic polo-like kinase 1 using recombinant proteins expressed in and purified from insect cells [6].


  1. Down-regulation of RAB6KIFL/KIF20A, a kinesin involved with membrane trafficking of discs large homologue 5, can attenuate growth of pancreatic cancer cell. Taniuchi, K., Nakagawa, H., Nakamura, T., Eguchi, H., Ohigashi, H., Ishikawa, O., Katagiri, T., Nakamura, Y. Cancer Res. (2005) [Pubmed]
  2. cDNA cloning, expression pattern, genomic structure and chromosomal location of RAB6KIFL, a human kinesin-like gene. Lai, F., Fernald, A.A., Zhao, N., Le Beau, M.M. Gene (2000) [Pubmed]
  3. The Rab6-binding kinesin, Rab6-KIFL, is required for cytokinesis. Hill, E., Clarke, M., Barr, F.A. EMBO J. (2000) [Pubmed]
  4. The human kinesin-like protein RB6K is under tight cell cycle control and is essential for cytokinesis. Fontijn, R.D., Goud, B., Echard, A., Jollivet, F., van Marle, J., Pannekoek, H., Horrevoets, A.J. Mol. Cell. Biol. (2001) [Pubmed]
  5. The small GTPase Rab6B, a novel Rab6 subfamily member, is cell-type specifically expressed and localised to the Golgi apparatus. Opdam, F.J., Echard, A., Croes, H.J., van den Hurk, J.A., van de Vorstenbosch, R.A., Ginsel, L.A., Goud, B., Fransen, J.A. J. Cell. Sci. (2000) [Pubmed]
  6. Assay and functional properties of Rabkinesin-6/Rab6-KIFL/MKlp2 in cytokinesis. Neef, R., Grüneberg, U., Barr, F.A. Meth. Enzymol. (2005) [Pubmed]
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