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Gene Review

sodC  -  superoxide dismutase

Escherichia coli CFT073

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Disease relevance of sodC


High impact information on sodC

  • Mutants lacking both sodC genes are less lethal for mice than mutants possessing either sodC locus alone, indicating that both Cu, Zn-SOD enzymes contribute to Salmonella pathogenicity [2].
  • Three independent domains of Haemophilus-like DNA were found in the meningococcal chromosome, associated respectively with the virulence gene sodC, the bio gene cluster, and an unidentified orf [1].
  • However, we have found only a slight difference in survival within HeLa cells between a sodC-null mutant and its isogenic wild-type strain [3].
  • The sodC gene encoding the periplasmic enzyme copper/zinc superoxide dismutase (CuZnSOD) has been cloned from Haemophilus ducreyi, the causative agent of the genital ulcer disease, chancroid [5].
  • An analysis of their growth phase-dependent gene expression indicated that a high level of the sodC expression occurred during the stationary phase and that the expression of the tpx gene was strongly induced only during the exponential growth phase [6].

Chemical compound and disease context of sodC


Analytical, diagnostic and therapeutic context of sodC

  • A 294 bp gene-specific fragment was amplified from the organism by DNA as well as RT-PCR using primers from bacterial sodC sequences [7].


  1. Natural genetic exchange between Haemophilus and Neisseria: intergeneric transfer of chromosomal genes between major human pathogens. Kroll, J.S., Wilks, K.E., Farrant, J.L., Langford, P.R. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  2. Virulent Salmonella typhimurium has two periplasmic Cu, Zn-superoxide dismutases. Fang, F.C., DeGroote, M.A., Foster, J.W., Bäumler, A.J., Ochsner, U., Testerman, T., Bearson, S., Giárd, J.C., Xu, Y., Campbell, G., Laessig, T. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  3. Increased expression of periplasmic Cu,Zn superoxide dismutase enhances survival of Escherichia coli invasive strains within nonphagocytic cells. Battistoni, A., Pacello, F., Folcarelli, S., Ajello, M., Donnarumma, G., Greco, R., Ammendolia, M.G., Touati, D., Rotilio, G., Valenti, P. Infect. Immun. (2000) [Pubmed]
  4. Brucella abortus strain RB51 as a vector for heterologous protein expression and induction of specific Th1 type immune responses. Vemulapalli, R., He, Y., Boyle, S.M., Sriranganathan, N., Schurig, G.G. Infect. Immun. (2000) [Pubmed]
  5. Distribution, cloning, characterisation and mutagenesis of sodC, the gene encoding copper/zinc superoxide dismutase, a potential determinant of virulence, in Haemophilus ducreyi. Langford, P.R., Kroll, J.S. FEMS Immunol. Med. Microbiol. (1997) [Pubmed]
  6. The role of periplasmic antioxidant enzymes (superoxide dismutase and thiol peroxidase) of the Shiga toxin-producing Escherichia coli O157:H7 in the formation of biofilms. Kim, Y.H., Lee, Y., Kim, S., Yeom, J., Yeom, S., Seok Kim, B., Oh, S., Park, S., Jeon, C.O., Park, W. Proteomics (2006) [Pubmed]
  7. Identification of copper-zinc superoxide dismutase gene from enteroaggregative Escherichia coli. Kumar, R., Sidhu, M.K., Ganguly, N.K., Chakraborti, A. Microbiol. Immunol. (1999) [Pubmed]
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