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MeSH Review

Neisseria meningitidis

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Disease relevance of Neisseria meningitidis


High impact information on Neisseria meningitidis

  • Clinical efficacy of meningococcus group A capsular polysaccharide vaccine in children three months to five years of age [5].
  • The cases, mainly in teenagers and young adults, were clustered in the Stroud district and in the southern part of Gloucester City, and most were caused by a sulphonamide-resistant group B type 15 meningococcus [6].
  • A highly significant association was found between the Km(1) allotype and the immune responses (difference between post-immunisation and pre-immunisation antibody levels) to H. influenzae and meningococcus C polysaccharides in the White children [7].
  • Here we describe a monoclonal antibody raised against the capsular polysaccharides of meningococcus group B (Men B) which specifically distinguishes embryonic N-CAM from adult N-CAM [8].
  • We tested C4bp binding to wild-type group B meningococcus strain (H44/76) and to 11 isogenic mutants thereof that differed in capsule expression, lipo-oligosaccharide sialylation, and/or expression of either porin (Por) A or PorB3 [9].

Chemical compound and disease context of Neisseria meningitidis


Biological context of Neisseria meningitidis


Gene context of Neisseria meningitidis

  • However, postimmunization sera induced significant bactericidal activity against group B meningococcus when combined with rabbit complement [17].
  • XcbA exhibited 52% amino acid similarity to SacB, the putative capsule polymerase of meningococcus serogroup A, suggesting that it plays a role as the serogroup X capsule polymerase [18].
  • The expression of a fully acylated, unglycosylated lipid A indicates that lipid A biosynthesis in N. meningitidis can proceed without the addition of Kdo and that KdtA is not essential for survival of the meningococcus [19].
  • To examine the protective efficacy of specific immune sera generated by meningococcal vaccine candidates against nasopharyngeal colonization, we developed an infant rat nasal colonization model for group B meningococcus [20].
  • A monoclonal antibody against Meningococcus group B polysaccharides used to immunocapture and quantify polysialylated NCAM in tissues and biological fluids [21].

Analytical, diagnostic and therapeutic context of Neisseria meningitidis


  1. NZB mouse system for production of monoclonal antibodies to weak bacterial antigens: isolation of an IgG antibody to the polysaccharide capsules of Escherichia coli K1 and group B meningococci. Frosch, M., Görgen, I., Boulnois, G.J., Timmis, K.N., Bitter-Suermann, D. Proc. Natl. Acad. Sci. U.S.A. (1985) [Pubmed]
  2. Interspecies recombination in nature: a meningococcus that has acquired a gonococcal PIB porin. Vázquez, J.A., Berrón, S., O'Rourke, M., Carpenter, G., Feil, E., Smith, N.H., Spratt, B.G. Mol. Microbiol. (1995) [Pubmed]
  3. Neisseria meningitidis serogroup C polysaccharide and serogroup B outer membrane vesicle conjugate as a bivalent meningococcus vaccine candidate. Fukasawa, L.O., Gorla, M.C., Schenkman, R.P., Garcia, L.R., Carneiro, S.M., Raw, I., Tanizaki, M.M. Vaccine (1999) [Pubmed]
  4. Comparative activity of six beta-lactam antibiotics against strains of Haemophilus influenzae, Neisseria meningitidis and Streptococcus pneumoniae. Soares, L.A., Melles, C.E. Infection (1982) [Pubmed]
  5. Clinical efficacy of meningococcus group A capsular polysaccharide vaccine in children three months to five years of age. Peltola, H., Mäkelä, H., Käyhty, H., Jousimies, H., Herva, E., Hällström, K., Sivonen, A., Renkonen, O.V., Pettay, O., Karanko, V., Ahvonen, P., Sarna, S. N. Engl. J. Med. (1977) [Pubmed]
  6. An outbreak of meningococcal disease in Gloucestershire. Cartwright, K.A., Stuart, J.M., Noah, N.D. Lancet (1986) [Pubmed]
  7. Association between immunoglobulin allotypes and immune responses to Haemophilus influenzae and Meningococcus polysaccharides. Pandey, J.P., Fudenberg, H.H., Virella, G., Kyong, C.U., Loadholt, C.B., Galbraith, R.M., Gotschlich, E.C., Parke, J.C. Lancet (1979) [Pubmed]
  8. A monoclonal antibody against meningococcus group B polysaccharides distinguishes embryonic from adult N-CAM. Rougon, G., Dubois, C., Buckley, N., Magnani, J.L., Zollinger, W. J. Cell Biol. (1986) [Pubmed]
  9. Binding of the complement inhibitor C4bp to serogroup B Neisseria meningitidis. Jarva, H., Ram, S., Vogel, U., Blom, A.M., Meri, S. J. Immunol. (2005) [Pubmed]
  10. Isolation and identification of a glutathione peroxidase homolog gene, gpxA, present in Neisseria meningitidis but absent in Neisseria gonorrhoeae. Moore, T.D., Sparling, P.F. Infect. Immun. (1995) [Pubmed]
  11. Anomalous cellular morphology and growth characteristics of Neisseria meningitidis in subminimal inhibitory concentrations of penicillin G. Neirinck, L.G., DeVoe, I.W. Antimicrob. Agents Chemother. (1981) [Pubmed]
  12. Maltose-negative Neisseria meningitidis isolated from a case of male urethritis. Phillips, E.A., Shultz, T.R., Tapsall, J.W., Chambers, I.W. J. Clin. Microbiol. (1989) [Pubmed]
  13. Haemophilus influenzae type b polysaccharide-protein conjugate vaccine. Tai, J.Y., Vella, P.P., McLean, A.A., Woodhour, A.F., McAleer, W.J., Sha, A., Dennis-Sykes, C., Hilleman, M.R. Proc. Soc. Exp. Biol. Med. (1987) [Pubmed]
  14. The changing epidemiology of meningococcal meningitis after introduction of bivalent A/C polysaccharide vaccine into school-based vaccination programs in Egypt. Nakhla, I., Frenck, R.W., Teleb, N.A., Oun, S.E., Sultan, Y., Mansour, H., Mahoney, F. Vaccine (2005) [Pubmed]
  15. Three homologues, including two membrane-bound proteins, of the disulfide oxidoreductase DsbA in Neisseria meningitidis: effects on bacterial growth and biogenesis of functional type IV pili. Tinsley, C.R., Voulhoux, R., Beretti, J.L., Tommassen, J., Nassif, X. J. Biol. Chem. (2004) [Pubmed]
  16. Emergence of drug resistance. Impact on bacterial meningitis. Klugman, K.P., Madhi, S.A. Infect. Dis. Clin. North Am. (1999) [Pubmed]
  17. Vaccination of small cell lung cancer patients with polysialic acid or N-propionylated polysialic acid conjugated to keyhole limpet hemocyanin. Krug, L.M., Ragupathi, G., Ng, K.K., Hood, C., Jennings, H.J., Guo, Z., Kris, M.G., Miller, V., Pizzo, B., Tyson, L., Baez, V., Livingston, P.O. Clin. Cancer Res. (2004) [Pubmed]
  18. Genetic basis for biosynthesis of the (alpha 1-->4)-linked N-acetyl-D-glucosamine 1-phosphate capsule of Neisseria meningitidis serogroup X. Tzeng, Y.L., Noble, C., Stephens, D.S. Infect. Immun. (2003) [Pubmed]
  19. Endotoxin of Neisseria meningitidis composed only of intact lipid A: inactivation of the meningococcal 3-deoxy-D-manno-octulosonic acid transferase. Tzeng, Y.L., Datta, A., Kolli, V.K., Carlson, R.W., Stephens, D.S. J. Bacteriol. (2002) [Pubmed]
  20. Passive immunization with Neisseria meningitidis PorA specific immune sera reduces nasopharyngeal colonization of group B meningococcus in an infant rat nasal challenge model. Schmidt, S., Zhu, D., Barniak, V., Mason, K., Zhang, Y., Arumugham, R., Metcalf, T. Vaccine (2001) [Pubmed]
  21. A monoclonal antibody against Meningococcus group B polysaccharides used to immunocapture and quantify polysialylated NCAM in tissues and biological fluids. Dubois, C., Okandze, A., Figarella-Branger, D., Rampini, C., Rougon, G. J. Immunol. Methods (1995) [Pubmed]
  22. Latex agglutination for bacterial antigens and meningococcus PCR: two useful tools in legal sudden deaths. Fernández-Rodríguez, A., Vázquez, J.A., Suárez-Mier, M.P., Aguilera, B., Ballesteros, S., De la Fuente, L., Vallejo, G., Sancho, M. Forensic Sci. Int. (2005) [Pubmed]
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