The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Chancroid


High impact information on Chancroid


Chemical compound and disease context of Chancroid


Biological context of Chancroid


Anatomical context of Chancroid

  • These data support the hypothesis that the H. ducreyi hemolysin is important in the pathogenesis of chancroid and may contribute to ulcer formation, invasion of epithelial cells, and evasion of the immune response [18].
  • IL-8 produced in response to H. ducreyi infection may be involved in recruiting polymorphonuclear leukocytes and other inflammatory cells, thereby contributing to the tissue necrosis and ulcer formation characteristic of chancroid [19].
  • Finally, we wanted to examine the importance of keratinocyte adhesion in chancroid pathogenesis so we tested the wild-type and dsrA mutant strains of H. ducreyi in our swine models of chancroid pathogenesis [20].

Gene context of Chancroid

  • When evaluated in the temperature-dependent rabbit model for chancroid, the lspA1 lspA2 double mutant was substantially less virulent than the wild-type strain 35000HP [21].
  • The dsrA mutant was less virulent than the wild type in both the normal and immune cell-depleted swine models of chancroid infection [20].
  • Both the cdtA mutant and the cdtB mutant were found to be fully virulent in the temperature-dependent rabbit model for experimental chancroid [22].
  • The isogenic H. ducreyi cdtC mutant was shown to be as virulent as its wild-type parent strain in the temperature-dependent rabbit model for experimental chancroid [23].
  • An H. ducreyi mutant with an inactivated tadA gene exhibited a small decrease in virulence in the temperature-dependent rabbit model for experimental chancroid, whereas another H. ducreyi mutant with inactivated flp-1 and flp-2 genes was as virulent as the wild-type parent strain [24].

Analytical, diagnostic and therapeutic context of Chancroid


  1. CCR4 versus CCR10 in human cutaneous TH lymphocyte trafficking. Soler, D., Humphreys, T.L., Spinola, S.M., Campbell, J.J. Blood (2003) [Pubmed]
  2. Investigation of the kinetic mechanism of cytidine 5'-monophosphate N-acetylneuraminic acid synthetase from Haemophilus ducreyi with new insights on rate-limiting steps from product inhibition analysis. Samuels, N.M., Gibson, B.W., Miller, S.M. Biochemistry (1999) [Pubmed]
  3. An investigation of genital ulcers in Jackson, Mississippi, with use of a multiplex polymerase chain reaction assay: high prevalence of chancroid and human immunodeficiency virus infection. Mertz, K.J., Weiss, J.B., Webb, R.M., Levine, W.C., Lewis, J.S., Orle, K.A., Totten, P.A., Overbaugh, J., Morse, S.A., Currier, M.M., Fishbein, M., St Louis, M.E. J. Infect. Dis. (1998) [Pubmed]
  4. A randomized, double-blind study of the efficacy of fleroxacin versus trimethoprim-sulfamethoxazole in men with culture-proven chancroid. Plourde, P.J., D'Costa, L.J., Agoki, E., Ombette, J., Ndinya-Achola, J.O., Slaney, L.A., Ronald, A.R., Plummer, F.A. J. Infect. Dis. (1992) [Pubmed]
  5. Recent changes in the epidemiology of genital ulcer disease in the United States. The crack cocaine connection. Martin, D.H., DiCarlo, R.P. Sexually transmitted diseases. (1994) [Pubmed]
  6. Single-dose therapy of chancroid with trimethoprim-sulfametrole. Plummer, F.A., Nsanze, H., D'Costa, L.J., Karasira, P., Maclean, I.W., Ellison, R.H., Ronald, A.R. N. Engl. J. Med. (1983) [Pubmed]
  7. Treatment of chancroid. Comparison of sulfamethoxazole-trimethoprim with recommended therapies. Fitzpatrick, J.E., Tyler, H., Gramstad, N.D. JAMA (1981) [Pubmed]
  8. Single-dose thiamphenicol for chancroid. Latif, A.S., Lencioni, R., Crocchiolo, P., Esposito, R. Lancet (1982) [Pubmed]
  9. Fleroxacin in the treatment of chancroid: an open study in men seropositive or seronegative for the human immunodeficiency virus type 1. Tyndall, M.W., Plourde, P.J., Agoki, E., Malisa, W., Ndinya-Achola, J.O., Plummer, F.A., Ronald, A.R. Am. J. Med. (1993) [Pubmed]
  10. Treatment of chancroid with ciprofloxacin. A prospective, randomized clinical trial. Naamara, W., Plummer, F.A., Greenblatt, R.M., D'Costa, L.J., Ndinya-Achola, J.O., Ronald, A.R. Am. J. Med. (1987) [Pubmed]
  11. Antimicrobial therapy of chancroid: effectiveness of erythromycin. Plummer, F.A., D'Costa, L.J., Nsanze, H., Maclean, I.W., Karasira, P., Piot, P., Fast, M.V., Ronald, A.R. J. Infect. Dis. (1983) [Pubmed]
  12. Single-dose ceftriaxone for chancroid. Bowmer, M.I., Nsanze, H., D'Costa, L.J., Dylewski, J., Fransen, L., Piot, P., Ronald, A.R. Antimicrob. Agents Chemother. (1987) [Pubmed]
  13. Prevention of experimental Haemophilus ducreyi infection: a randomized, controlled clinical trial. Thornton, A.C., O'Mara, E.M., Sorensen, S.J., Hiltke, T.J., Fortney, K., Katz, B., Shoup, R.E., Hood, A.F., Spinola, S.M. J. Infect. Dis. (1998) [Pubmed]
  14. Neutropenia restores virulence to an attenuated Cu,Zn superoxide dismutase-deficient Haemophilus ducreyi strain in the swine model of chancroid. San Mateo, L.R., Toffer, K.L., Orndorff, P.E., Kawula, T.H. Infect. Immun. (1999) [Pubmed]
  15. An outbreak of chancroid in Orange County, California: descriptive epidemiology and disease-control measures. Blackmore, C.A., Limpakarnjanarat, K., Rigau-Pérez, J.G., Albritton, W.L., Greenwood, J.R. J. Infect. Dis. (1985) [Pubmed]
  16. Correlation between in vitro antimicrobial susceptibilities and beta-lactamase plasmid contents of isolates of Haemophilus ducreyi from the United States. Motley, M., Sarafian, S.K., Knapp, J.S., Zaidi, A.A., Schmid, G. Antimicrob. Agents Chemother. (1992) [Pubmed]
  17. Treatment of chancroid. A comparison of sulphamethoxazole and trimethoprim-sulphamethoxazole. Fast, M.V., Nsanze, H., Plummer, F.A., D'Costa, L.J., MacLean, I.W., Ronald, A.R. The British journal of venereal diseases. (1983) [Pubmed]
  18. Target cell range of Haemophilus ducreyi hemolysin and its involvement in invasion of human epithelial cells. Wood, G.E., Dutro, S.M., Totten, P.A. Infect. Immun. (1999) [Pubmed]
  19. Haemophilus ducreyi infection causes basal keratinocyte cytotoxicity and elicits a unique cytokine induction pattern in an In vitro human skin model. Hobbs, M.M., Paul, T.R., Wyrick, P.B., Kawula, T.H. Infect. Immun. (1998) [Pubmed]
  20. The Haemophilus ducreyi serum resistance antigen DsrA confers attachment to human keratinocytes. Cole, L.E., Kawula, T.H., Toffer, K.L., Elkins, C. Infect. Immun. (2002) [Pubmed]
  21. Mutations in the lspA1 and lspA2 genes of Haemophilus ducreyi affect the virulence of this pathogen in an animal model system. Ward, C.K., Latimer, J.L., Nika, J., Vakevainen, M., Mock, J.R., Deng, K., Blick, R.J., Hansen, E.J. Infect. Immun. (2003) [Pubmed]
  22. Characterization of Haemophilus ducreyi cdtA, cdtB, and cdtC mutants in in vitro and in vivo systems. Lewis, D.A., Stevens, M.K., Latimer, J.L., Ward, C.K., Deng, K., Blick, R., Lumbley, S.R., Ison, C.A., Hansen, E.J. Infect. Immun. (2001) [Pubmed]
  23. Characterization of a Haemophilus ducreyi mutant deficient in expression of cytolethal distending toxin. Stevens, M.K., Latimer, J.L., Lumbley, S.R., Ward, C.K., Cope, L.D., Lagergard, T., Hansen, E.J. Infect. Immun. (1999) [Pubmed]
  24. Haemophilus ducreyi requires the flp gene cluster for microcolony formation in vitro. Nika, J.R., Latimer, J.L., Ward, C.K., Blick, R.J., Wagner, N.J., Cope, L.D., Mahairas, G.G., Munson, R.S., Hansen, E.J. Infect. Immun. (2002) [Pubmed]
  25. Sexually transmitted diseases and human immunodeficiency virus control in Malawi: a field study of genital ulcer disease. Behets, F.M., Liomba, G., Lule, G., Dallabetta, G., Hoffman, I.F., Hamilton, H.A., Moeng, S., Cohen, M.S. J. Infect. Dis. (1995) [Pubmed]
  26. Molecular characterization of Haemophilus ducreyi by ribosomal DNA fingerprinting. Sarafian, S.K., Woods, T.C., Knapp, J.S., Swaminathan, B., Morse, S.A. J. Clin. Microbiol. (1991) [Pubmed]
  27. Efficacy and safety of a single dose therapy of a 500 mg ciprofloxacin tablet in chancroid patients. Traisupa, A., Wongba, C., Tesavibul, P. Infection (1988) [Pubmed]
WikiGenes - Universities