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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
MeSH Review

Chancroid

 
 
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Disease relevance of Chancroid

 

High impact information on Chancroid

 

Chemical compound and disease context of Chancroid

 

Biological context of Chancroid

 

Anatomical context of Chancroid

  • These data support the hypothesis that the H. ducreyi hemolysin is important in the pathogenesis of chancroid and may contribute to ulcer formation, invasion of epithelial cells, and evasion of the immune response [18].
  • IL-8 produced in response to H. ducreyi infection may be involved in recruiting polymorphonuclear leukocytes and other inflammatory cells, thereby contributing to the tissue necrosis and ulcer formation characteristic of chancroid [19].
  • Finally, we wanted to examine the importance of keratinocyte adhesion in chancroid pathogenesis so we tested the wild-type and dsrA mutant strains of H. ducreyi in our swine models of chancroid pathogenesis [20].
 

Gene context of Chancroid

  • When evaluated in the temperature-dependent rabbit model for chancroid, the lspA1 lspA2 double mutant was substantially less virulent than the wild-type strain 35000HP [21].
  • The dsrA mutant was less virulent than the wild type in both the normal and immune cell-depleted swine models of chancroid infection [20].
  • Both the cdtA mutant and the cdtB mutant were found to be fully virulent in the temperature-dependent rabbit model for experimental chancroid [22].
  • The isogenic H. ducreyi cdtC mutant was shown to be as virulent as its wild-type parent strain in the temperature-dependent rabbit model for experimental chancroid [23].
  • An H. ducreyi mutant with an inactivated tadA gene exhibited a small decrease in virulence in the temperature-dependent rabbit model for experimental chancroid, whereas another H. ducreyi mutant with inactivated flp-1 and flp-2 genes was as virulent as the wild-type parent strain [24].
 

Analytical, diagnostic and therapeutic context of Chancroid

References

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  18. Target cell range of Haemophilus ducreyi hemolysin and its involvement in invasion of human epithelial cells. Wood, G.E., Dutro, S.M., Totten, P.A. Infect. Immun. (1999) [Pubmed]
  19. Haemophilus ducreyi infection causes basal keratinocyte cytotoxicity and elicits a unique cytokine induction pattern in an In vitro human skin model. Hobbs, M.M., Paul, T.R., Wyrick, P.B., Kawula, T.H. Infect. Immun. (1998) [Pubmed]
  20. The Haemophilus ducreyi serum resistance antigen DsrA confers attachment to human keratinocytes. Cole, L.E., Kawula, T.H., Toffer, K.L., Elkins, C. Infect. Immun. (2002) [Pubmed]
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